In particular, Schliesser explores the rich resonances between Newton's and Spinoza's metaphysics. Schliesser presents a new argument of the ways in which Newton and his circle respond to the treatment and accusations of Spinozism, illuminating both the details of Newton's metaphysics and the content of Spinoza's. Schliesser provides a fine-grained analysis of some of the key metaphysical concepts in Newton's physics, including controversial interpretations of Newton's ideas on space, time, inertia, and necessity. Schliesser restates his provocative interpretation of Newton's views on action at a distance as he was developing the Principia.

Newton's Metaphysics contains a substantive introduction, two chapters co-authored with Zvi Biener and with Mary Domski, new chapters on Newton's modal metaphysics and his theology, and two postscripts in which Schliesser responds to some of his most important critics, including Katherine Brading, Andrew Janiak, Hylarie Kochiras, Steffen Ducheyne, and Adwait Parker. The collection presents new and varied analyses on familiar focuses of Newton's work, adding important perspectives to the recent revival of interest in Spinoza's metaphysics.