Infusion therapy -- drug treatment administered intravenously -- was once provided strictly in hospitals. However, clinical developments and emphasis on cost containment have prompted a shift to other settings, including the home. Home infusion requires coordination among providers of drugs, equipment, and skilled nursing care. It describes: (1) coverage of home infusion therapy components under Medicare fee-for-service (FFS); (2) coverage and payment for home infusion therapy by other health insurers -- both commercial plans and Medicare Advantage plans, which provide a private alternative to Medicare FFS; and (3) the utilization and quality management practices that health insurers use with home infusion therapy benefits. Illustrations.