This book constitutes the thoroughly refereed proceedings of the 12th International Conference on e-Infrastructure and e-Services for Developing Countries, AFRICOMM 2020, held in Ebène City, Mauritius, in December 2020. Due to COVID-19 pandemic the conference was held virtually. The 20 full papers were carefully selected from 90 submissions. The papers are organized in four thematic sections on dynamic spectrum access and mesh networks; wireless sensing and 5G networks; software-defined networking; Internet of Things; e-services and big data; DNS resilience and performance.