As manufacturing supply chains have moved from vertically integrated factories to diffused networks, manufacturers need to manage complex, global webs of suppliers. In this chapter, Netessine examines supply networks in two industries in particular: automobiles, and aerospace and defense. He explores how different strategies and technologies have helped companies manage, organize, and capitalize on their networks of suppliers. He discusses how Japanese automakers have used partnerships to outperform their U.S. rivals, who have taken a more adversarial approach to their suppliers. He also considers how companies such as Airbus and Boeing have used technology to coordinate and integrate far-flung networks. While Netessine notes that the formal study of network-based supply chains is just emerging, he offers insights from research and practice on the growing importance of supply networks and strategies for managing them successfully.