Plasmapheresis: Plasmapheresis is an experimental procedure used to assess the importance of plasma Proteins 7. Hasan Veterinary College, Hasan, Karnataka in maintaining homeostasis in animals. This procedure was also called as Whipple’s experiment because it was established by George Hoyt Whipple.

Procedure: This procedure is also broadly referred to as ‘Tissue plasma exchange’. Blood will be removed from the body of experimental dog. Erythrocytes are then separated form plasma and are re-suspended in a physiological solution called Locke’s solution. Then this suspension is re-infused into the body of the same dog. Because this procedure involves removal of plasma proteins, a sudden deficiency of plasma proteins leads to state of shock in animal.