NEW! The Bigger Picture bulleted summaries identify other body systems that might be affected by a particular disease or disorder covered in a body system chapter. NEW coverage of COVID-19 is added, as well as new information on other conditions and diseases. NEW diagnostic methods and treatments are covered, describing how these are impacted by digitalization, information technology, and artificial intelligence. NEW! Updated statistics on diseases and their related pathophysiology are included. NEW photographs and illustrations are added.