This book introduces readers to the latest advances in and approaches to intuitionistic fuzzy decision-making methods. To do so, it explores a range of applications to practical decision-making problems, together with representative case studies. Examining a host of decision-making methods, most of which are based on intuitionistic fuzzy aggregation operators, its goal is to offer readers a new way to study decision-making methods in the intuitionistic fuzzy environment. Chiefly intended for practitioners and researchers working in the areas of risk management, decision-making under uncertainty, and operational research, the book can also be used as supplementary material for graduate and senior undergraduate courses in these areas.
The role of epigenetic histone modifications in the pathogenesis and regulation of eye diseases has received increasing attention. Among these modifications, histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), is crucial for regulating gene expression under disease conditions in the eye. Hence, eye diseases are closely linked to the imbalance between the acetylation and deacetylation of histone proteins. Moreover, most HDAC inhibitors (HDACis) and several HDAC activators have demonstrated high therapeutic potential in animal models of and in patients with eye diseases. Focusing on the molecular aspects of HATs, HDACs, HDACis, and HDAC activators, this book reviews recent advances in histone acetylation in ocular surface diseases, cataracts, glaucoma, uveitis, and multiple retinal diseases and discusses the effects and mechanisms of action of these enzymes and molecules, with the goal of identifying novel targets for the prevention and treatment of these eye diseases.
This book introduces readers to the latest advances in and approaches to intuitionistic fuzzy decision-making methods. To do so, it explores a range of applications to practical decision-making problems, together with representative case studies. Examining a host of decision-making methods, most of which are based on intuitionistic fuzzy aggregation operators, its goal is to offer readers a new way to study decision-making methods in the intuitionistic fuzzy environment. Chiefly intended for practitioners and researchers working in the areas of risk management, decision-making under uncertainty, and operational research, the book can also be used as supplementary material for graduate and senior undergraduate courses in these areas.
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