Annotation Micro RNAs (miRNAs) are known to play an important role in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiovascular disorders, metabolic disturbances, etc. Unique expression profiles have been associated with specific pathological states.Cardiovascular disease is among the main causes of mortality in developed countries. The pathological process of the heart is associated with altered expression profile of genes that are important for cardiac function. The implications of miRNAs in the pathological process of the cardiovascular system have recently been recognized, and the research on miRNAs in relation to cardiovascular disease is now in rapid progress. The aim of this ebook is to present updated research on the subject with analyses from published reports. Micro RNAs and Cardiovascular Disease caters to the growing interest and information needs of cardiac clinicians and gene expression researchers
This book discusses non-orthogonal multiple access (NOMA) and the various issues in NOMA networks, including capability, sustainability, and security. This book starts from the basics and key techniques of NOMA. Subsequently, the authors discuss three critical issues in NOMA networks, including compatibility, sustainability, and security. Particularly, the authors first demonstrate the applications of NOMA in different networks including MIMO-NOMA, NOMA in heterogeneous networks, and NOMA in cognitive radio networks to show the compatibility of NOMA with various networks. Then the wireless powered NOMA networks are presented to address the sustainability issues in NOMA networks to extend the network reliability and lifetime. The security enhanced NOMA networks are discussed for single antenna case and multiple antenna case, respectively. Finally, the most recent developments on artificial intelligence (AI) enabled NOMA networks are discussed and the research challenges on NOMA to support massive number of devices are identified.
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.
Metal halide perovskites are the hottest materials currently.This unique compendium covers systematically the fundamental aspects of synthesis, properties, and applications of metal halide perovskites that exhibit unique properties and useful functionalities.Written for beginners and practitioners, this useful reference text provides a good balance between fundamental concepts/principles and related recent researches with many highlighted examples.This volume benefits researchers, practitioners, graduate students in materials chemistry/nanochemistry, physical chemistry and semiconductors.
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of - nucleotides, have rapidly emerged as the central players in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiov- cular disorders, metabolic disturbances, etc. Particular expression pro?les have been associated with particular pathological states. Expression pro?ling of miR- NAs have therefore become extremely important not only for fundamentalists but also for clinicians. However, the methodologies used for detecting protein-coding mRNAs cannot be directly applied to miRNAs because of their small size. Over the past years, researchers have made great efforts to developing techniques suitable for miRNA detection and quanti?cation; a wide spectrum of creative and inno- tive techniques (more than 30 different methods) have been invented and validated. It has come to the time now to summarize these methods and present them in an orderly manner for better understanding and utilization of these methods to miRNA research and applications. In particular, the development of methods for quantifying circulating miRNAs opens up a fascinating opportunity for realizing miRNA as diagnostic and prognostic biomarkers of human disease. A book on this subject may help boosting up the passion of researchers to further improve the existing techniques and develop more new methods to ?t to new application needs. These considerations prompted us and urged us to undertake the work: writing a book focusing on miRNA expression detection methods.
There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.
This book is a valuable work of reference for the study of sea power, especially in China. It analyzes the challenges and problems facing China’s sea power and offers a complete set of solutions known as ‘sea exploitation.’ In this context, it discusses five aspects of China’s sea power: 1) It revises the notion of sea power and proposes a cost-benefit analysis framework for it. It holds that sea power is undergoing major changes, that multivariate completion and peaceful competition have become mainstream, that negative and zero-sum games have become positive sum games, and that the pursuit of control over the sea has gradually developed into efforts to establish dominance in a partnership. 2) By analyzing the increase in the benefits of China’s sea power, the rise in the nation’s ability-to-pay principle and the growth in the public expectation of China’s capability of providing global public goods, it points out that the rise of China’s sea power is an unavoidable trend. 3) It explores the challenges and problems facing China’s sea power, arguing that China is currently in a situation where it is daunted by large countries, troubled by small countries and its neighbors are expanding their armaments, which have combined to increase the cost of improving China’s sea power. Meanwhile, factors such as strategy vacuum, poor oceanic management and polices tending to restrict ocean development have substantially undermined the benefits of China’s sea power. 4) It summarizes features of China’s sea power and stresses that dilemmas of non-sovereign sea power expansion and sovereign sea power expansion, traumatic pressure and transcendental ideals, escalated conflict and peaceful appeal, etc. require China to articulate its stance on sea power on the one hand and possess the wisdom to resolve sea power problems peacefully on the other. 5) It proposes that China should draw on the experience of the Western Han Dynasty of ancient China, which adopted a land exploitation strategy and introduced a sea exploitation strategy, offering a unique way to implement sea exploitation strategies in China based on domestic and foreign practices.
This book summarizes the technical method and construction process of pipe jacking. It has a total of 17 chapters and one appendix. It includes how to prepare the pipe jacking construction, how to choose the pipe and equipment for jacking, how to choose the engineering environment, how to do the geological survey before jacking, how to design the working pit, what's the procedure of pipe jacking, how to do the measurement and monitoring during jacking, how to do the treatment and acceptance after jacking, and so on. Appendix contains reference tables for pipe jacking archives, which might aid readers in understanding the book's content. This book's language is simple to read, and it has a wealth of graphics. Even those without a foundational understanding of pipe jacking could read and comprehend it with ease. This regulation could be the fundamental discipline for pipeline jacking projects. It is the important basis and criterion for the design, construction, management, inspection, and acceptance of pipeline jacking.
Several Python programming books feature tools designed for experimental psychologists. What sets this book apart is its focus on eye-tracking. Eye-tracking is a widely used research technique in psychology and neuroscience labs. Research grade eye-trackers are typically faster, more accurate, and of course, more expensive than the ones seen in consumer goods or usability labs. Not surprisingly, a successful eye-tracking study usually requires sophisticated computer programming. Easy syntax and flexibility make Python a perfect choice for this task, especially for psychology researchers with little or no computer programming experience. This book offers detailed coverage of the Pylink library, a Python interface for the gold standard EyeLink ® eye-trackers, with many step-by-step example scripts. This book is a useful reference for eye-tracking researchers, but you can also use it as a textbook for graduate-level programming courses.
Instrumentation, control and automation (ICA) in wastewater treatment systems is now an established and recognised area of technology in the profession. There are obvious incentives for ICA, not the least from an economic point of view. Plants are also becoming increasingly complex which necessitates automation and control. Instrumentation, Control and Automation in Wastewater Systems summarizes the state-of-the-art of ICA and its application in wastewater treatment systems and focuses on how leading-edge technology is used for better operation. The book is written for: The practising process engineer and the operator, who wishes to get an updated picture of what is possible to implement in terms of ICA; The process designer, who needs to consider the couplings between design and operation; The researcher or the student, who wishes to get the latest technological overview of an increasingly complex field. There is a clear aim to present a practical ICA approach, based on a technical and economic platform. The economic benefit of different control and operation possibilities is quantified. The more qualitative benefits, such as better process understanding and more challenging work for the operator are also described. Several full-scale experiences of how ICA has improved economy, ease of operation and robustness of plant operation are presented. The book emphasizes both unit process control and plant wide operation. Scientific & Technical Report No. 15
In a world where there is a growing awareness of the possible effects of human activities on climate change, there is a need to identify the emission of greenhouse gases (GHG) from wastewater treatment plants (WWTPs). As a result of this growing awareness, governments started to implement regulations that require water authorities to report their GHG emissions. With these developments there exists a strong need for adequate insight into the emissions of N2O and CH4. With this insight water authorities would be able to estimate and finally reduce their emissions. The overall objectives of the different research programs performed by partners of the GWRC members WERF (United States of America), WSAA (Australia), CIRSEE-Suez (France) and STOWA (the Netherlands) were: To define the origin of N2O emission. To understand the formation processes of N2O. To identify the level of CH4 emissions from wastewater collection and treatment systems. To evaluate the use of generic emission factors to estimate the emission of N2O from individual plants
The book provides insights into the development of special economic zones, which are an important factor in the political and economic reforms in China. It discusses a number of topics, including the history and the modernization of special economic zones in China, the contributions of special economic zones to China’s economic success and cultural change, as well as the new mission of special economic zones in the current economic-social context. Applying institutional economics and growth poles theory, it discusses the mechanism of China’s path driven by special economic zone practices. The book is a valuable resource for researchers interested in special economic zones, political and institutional reforms and economic transformation during China’s modernization.
This book shares the latest findings on this topic, systematically introduces readers to advances made in robotic harvesting around the globe, and explores the relations between the development of robotic harvesting and the respective social/economic conditions and agricultural business patterns in various countries/regions. Due to the unstructured setting it is used in, and to the significant differences between individual fruit and vegetable targets, robotic harvesting is currently considered to be one of the most challenging robotics technologies. Accordingly, research into this area involves the integration of various aspects, including biomechanics, optimization design, advanced perception and intelligent control. In addition to rapid and damage-free robotic harvesting, which reflects the multidisciplinary nature of the topic, further aspects addressed include gripping collisions with viscoelastic objects, using lasers to cut plant material, plant-fruit response to vacuum sucking and pulling, and performance probability distribution. Highlighting outstanding innovations and reflecting the latest advances in intelligent agricultural equipment in China, the book offers a unique and valuable resource.
The book provides insights into the development of special economic zones, which are an important factor in the political and economic reforms in China. It discusses a number of topics, including the history and the modernization of special economic zones in China, the contributions of special economic zones to China’s economic success and cultural change, as well as the new mission of special economic zones in the current economic-social context. Applying institutional economics and growth poles theory, it discusses the mechanism of China’s path driven by special economic zone practices. The book is a valuable resource for researchers interested in special economic zones, political and institutional reforms and economic transformation during China’s modernization.
This book summarizes the technical method and construction process of pipe jacking. It has a total of 17 chapters and one appendix. It includes how to prepare the pipe jacking construction, how to choose the pipe and equipment for jacking, how to choose the engineering environment, how to do the geological survey before jacking, how to design the working pit, what's the procedure of pipe jacking, how to do the measurement and monitoring during jacking, how to do the treatment and acceptance after jacking, and so on. Appendix contains reference tables for pipe jacking archives, which might aid readers in understanding the book's content. This book's language is simple to read, and it has a wealth of graphics. Even those without a foundational understanding of pipe jacking could read and comprehend it with ease. This regulation could be the fundamental discipline for pipeline jacking projects. It is the important basis and criterion for the design, construction, management, inspection, and acceptance of pipeline jacking.
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.
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