Zhiguo Li's Books

MicroRNA Interference Technologies

By: Zhiguo Wang

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MicroRNA Interference Technologies

By: Zhiguo Wang

MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.

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Page Count

198

Publisher

Springer Science & Business Media

Published Date

ISBN 10

364200489X

ISBN 13

9783642004896

Polypharmacology

Principles and Methodologies

By: Zhiguo Wang,Baofeng Yang

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Polypharmacology

Principles and Methodologies

By: Zhiguo Wang,Baofeng Yang

There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.

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Page Count

870

Publisher

Springer Nature

Published Date

ISBN 10

3031049985

ISBN 13

9783031049989

MicroRNAs & Cardiovacular Disease

By: Zhiguo Wang

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MicroRNAs & Cardiovacular Disease

By: Zhiguo Wang

Annotation Micro RNAs (miRNAs) are known to play an important role in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiovascular disorders, metabolic disturbances, etc. Unique expression profiles have been associated with specific pathological states.Cardiovascular disease is among the main causes of mortality in developed countries. The pathological process of the heart is associated with altered expression profile of genes that are important for cardiac function. The implications of miRNAs in the pathological process of the cardiovascular system have recently been recognized, and the research on miRNAs in relation to cardiovascular disease is now in rapid progress. The aim of this ebook is to present updated research on the subject with analyses from published reports. Micro RNAs and Cardiovascular Disease caters to the growing interest and information needs of cardiac clinicians and gene expression researchers

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Page Count

150

Publisher

Bentham Science Publishers

Published Date

ISBN 10

1608051846

ISBN 13

9781608051847

Special Economic Zones and China’s Development Path

By: Yitao Tao,Zhiguo Lu

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Special Economic Zones and China’s Development Path

By: Yitao Tao,Zhiguo Lu

The book provides insights into the development of special economic zones, which are an important factor in the political and economic reforms in China. It discusses a number of topics, including the history and the modernization of special economic zones in China, the contributions of special economic zones to China’s economic success and cultural change, as well as the new mission of special economic zones in the current economic-social context. Applying institutional economics and growth poles theory, it discusses the mechanism of China’s path driven by special economic zone practices. The book is a valuable resource for researchers interested in special economic zones, political and institutional reforms and economic transformation during China’s modernization.

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Page Count

356

Publisher

Springer

Published Date

ISBN 10

9811032203

ISBN 13

9789811032202

MicroRNA Expression Detection Methods

By: Zhiguo Wang,Baofeng Yang

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MicroRNA Expression Detection Methods

By: Zhiguo Wang,Baofeng Yang

MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of - nucleotides, have rapidly emerged as the central players in gene expression regulation. Owing to their ever-increasing implications in the control of various biological and pathological processes, miRNAs have now been considered novel biomarkers of various human diseases including, cancer, viral disease, cardiov- cular disorders, metabolic disturbances, etc. Particular expression pro?les have been associated with particular pathological states. Expression pro?ling of miR- NAs have therefore become extremely important not only for fundamentalists but also for clinicians. However, the methodologies used for detecting protein-coding mRNAs cannot be directly applied to miRNAs because of their small size. Over the past years, researchers have made great efforts to developing techniques suitable for miRNA detection and quanti?cation; a wide spectrum of creative and inno- tive techniques (more than 30 different methods) have been invented and validated. It has come to the time now to summarize these methods and present them in an orderly manner for better understanding and utilization of these methods to miRNA research and applications. In particular, the development of methods for quantifying circulating miRNAs opens up a fascinating opportunity for realizing miRNA as diagnostic and prognostic biomarkers of human disease. A book on this subject may help boosting up the passion of researchers to further improve the existing techniques and develop more new methods to ?t to new application needs. These considerations prompted us and urged us to undertake the work: writing a book focusing on miRNA expression detection methods.

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Page Count

382

Publisher

Springer

Published Date

ISBN 10

3642049281

ISBN 13

9783642049286

Metal Halide Perovskites: Synthesis, Properties And Applications

By: Jin Zhong Zhang,Zhiguo Xia,Qi Pang

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Metal Halide Perovskites: Synthesis, Properties And Applications

By: Jin Zhong Zhang,Zhiguo Xia,Qi Pang

Metal halide perovskites are the hottest materials currently.This unique compendium covers systematically the fundamental aspects of synthesis, properties, and applications of metal halide perovskites that exhibit unique properties and useful functionalities.Written for beginners and practitioners, this useful reference text provides a good balance between fundamental concepts/principles and related recent researches with many highlighted examples.This volume benefits researchers, practitioners, graduate students in materials chemistry/nanochemistry, physical chemistry and semiconductors.

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Page Count

260

Publisher

World Scientific

Published Date

ISBN 10

9811257434

ISBN 13

9789811257438

The Making of a Maritime Power

China’s Challenges and Policy Responses

By: Zhiguo Kong

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The Making of a Maritime Power

China’s Challenges and Policy Responses

By: Zhiguo Kong

This book is a valuable work of reference for the study of sea power, especially in China. It analyzes the challenges and problems facing China’s sea power and offers a complete set of solutions known as ‘sea exploitation.’ In this context, it discusses five aspects of China’s sea power: 1) It revises the notion of sea power and proposes a cost-benefit analysis framework for it. It holds that sea power is undergoing major changes, that multivariate completion and peaceful competition have become mainstream, that negative and zero-sum games have become positive sum games, and that the pursuit of control over the sea has gradually developed into efforts to establish dominance in a partnership. 2) By analyzing the increase in the benefits of China’s sea power, the rise in the nation’s ability-to-pay principle and the growth in the public expectation of China’s capability of providing global public goods, it points out that the rise of China’s sea power is an unavoidable trend. 3) It explores the challenges and problems facing China’s sea power, arguing that China is currently in a situation where it is daunted by large countries, troubled by small countries and its neighbors are expanding their armaments, which have combined to increase the cost of improving China’s sea power. Meanwhile, factors such as strategy vacuum, poor oceanic management and polices tending to restrict ocean development have substantially undermined the benefits of China’s sea power. 4) It summarizes features of China’s sea power and stresses that dilemmas of non-sovereign sea power expansion and sovereign sea power expansion, traumatic pressure and transcendental ideals, escalated conflict and peaceful appeal, etc. require China to articulate its stance on sea power on the one hand and possess the wisdom to resolve sea power problems peacefully on the other. 5) It proposes that China should draw on the experience of the Western Han Dynasty of ancient China, which adopted a land exploitation strategy and introduced a sea exploitation strategy, offering a unique way to implement sea exploitation strategies in China based on domestic and foreign practices.

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Page Count

186

Publisher

Springer

Published Date

ISBN 10

9811017867

ISBN 13

9789811017865

Environmental Regulation of Oil and Gas

By: Zhiguo Gao,Chih-Kuo Kao

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Environmental Regulation of Oil and Gas

By: Zhiguo Gao,Chih-Kuo Kao

This book contains in-depth articles written by scholars, international lawyers, and practitioners from around the world. It deals with the environmental aspect of the hydrocarbon cycle in general and oil and gas exploration and production in particular. Its main thrust is management of environmental legal risks and issues in upstream operations.

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Page Count

652

Publisher

Kluwer Law International B.V.

Published Date

ISBN 10

9041107266

ISBN 13

9789041107268

Non-Orthogonal Multiple Access for Massive Connectivity

By: Yuanwei Liu,Zhijin Qin,Zhiguo Ding

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Non-Orthogonal Multiple Access for Massive Connectivity

By: Yuanwei Liu,Zhijin Qin,Zhiguo Ding

This book discusses non-orthogonal multiple access (NOMA) and the various issues in NOMA networks, including capability, sustainability, and security. This book starts from the basics and key techniques of NOMA. Subsequently, the authors discuss three critical issues in NOMA networks, including compatibility, sustainability, and security. Particularly, the authors first demonstrate the applications of NOMA in different networks including MIMO-NOMA, NOMA in heterogeneous networks, and NOMA in cognitive radio networks to show the compatibility of NOMA with various networks. Then the wireless powered NOMA networks are presented to address the sustainability issues in NOMA networks to extend the network reliability and lifetime. The security enhanced NOMA networks are discussed for single antenna case and multiple antenna case, respectively. Finally, the most recent developments on artificial intelligence (AI) enabled NOMA networks are discussed and the research challenges on NOMA to support massive number of devices are identified.

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Page Count

107

Publisher

Springer Nature

Published Date

ISBN 10

3030309754

ISBN 13

9783030309756

Rapid Damage-Free Robotic Harvesting of Tomatoes

By: Jizhan Liu,Zhiguo Li,Pingping Li

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Rapid Damage-Free Robotic Harvesting of Tomatoes

By: Jizhan Liu,Zhiguo Li,Pingping Li

This book shares the latest findings on this topic, systematically introduces readers to advances made in robotic harvesting around the globe, and explores the relations between the development of robotic harvesting and the respective social/economic conditions and agricultural business patterns in various countries/regions. Due to the unstructured setting it is used in, and to the significant differences between individual fruit and vegetable targets, robotic harvesting is currently considered to be one of the most challenging robotics technologies. Accordingly, research into this area involves the integration of various aspects, including biomechanics, optimization design, advanced perception and intelligent control. In addition to rapid and damage-free robotic harvesting, which reflects the multidisciplinary nature of the topic, further aspects addressed include gripping collisions with viscoelastic objects, using lasers to cut plant material, plant-fruit response to vacuum sucking and pulling, and performance probability distribution. Highlighting outstanding innovations and reflecting the latest advances in intelligent agricultural equipment in China, the book offers a unique and valuable resource.

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Page Count

460

Publisher

Springer Nature

Published Date

ISBN 10

9811612846

ISBN 13

9789811612848

Rapid Damage-Free Robotic Harvesting of Tomatoes

By: Jizhan Liu,Zhiguo Li,Pingping Li

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Rapid Damage-Free Robotic Harvesting of Tomatoes

By: Jizhan Liu,Zhiguo Li,Pingping Li

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Page Count

460

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Springer Nature

Published Date

ISBN 10

9811612846

ISBN 13

9789811612848

Book's by Zhiguo Li

MicroRNA Interference Technologies

MicroRNA Interference Technologies

Polypharmacology

Polypharmacology

MicroRNAs & Cardiovacular Disease

MicroRNAs & Cardiovacular Disease

Special Economic Zones and China’s Development Path

Special Economic Zones and China’s Development Path

MicroRNA Expression Detection Methods

MicroRNA Expression Detection Methods

Metal Halide Perovskites: Synthesis, Properties And Applications

Metal Halide Perovskites: Synthesis, Properties And Applications

The Making of a Maritime Power

The Making of a Maritime Power

Environmental Regulation of Oil and Gas

Environmental Regulation of Oil and Gas

Non-Orthogonal Multiple Access for Massive Connectivity

Non-Orthogonal Multiple Access for Massive Connectivity

Rapid Damage-Free Robotic Harvesting of Tomatoes

Rapid Damage-Free Robotic Harvesting of Tomatoes

Rapid Damage-Free Robotic Harvesting of Tomatoes

Rapid Damage-Free Robotic Harvesting of Tomatoes

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