Specific Interaction and Biological Recognition Processes is devoted to two major aspects of biological processes: specificity in biological recognition and the recognition processes themselves. Topics covered in specificity include the theoretical basis for specificity in biological recognition; the thermodynamic and chemical equilibrium background; and consideration of the relationship between size of combining sites and specificity. The use of semi-emperical potentials for calculating interaction energies and the potential of quantum chemistry methods for calculating receptor-effector affinities are also discussed. The various recognition processes described include DNA replication, transcription, translation, enzymatic reactions, transmembrane transport processes, mechanisms of action of hormones and other chemical messengers, and self-nonself recognition in immunology. Specific Interaction and Biological Recognition Processes will be a useful reference for molecular biologists, biochemists, enzymologists, immunologists oncologists, pharmaceutical researchers, and others interested in the topic.
This book presents a comprehensive review of the interaction between cancer research and mathematical methods for both investigators in the field and newcomers just entering it. The book's primary focus is on the use of computer-assisted mathematical modeling in carcinogenesis and cancer prevention. The first two chapters include a general presentation of the carcinogenesis and anticarcinogenesis molecular mechanisms, followed by a discussion of mathematical models of triggers for gene regulation. A description of the prediction of both carcinogenicity and mutagenicity using quantum mechanical, topological or physico-chemical indices is presented, as well as a discussion of the QSAR analysis of carcinogenesis-inhibiting compounds (known as blocking or suppressive agents).
Odell Williams grows up amid a humble background, encouraged by a loving mother who teaches him that working hard and treating people with dignity and respect will bring success. After vowing to make something out of his life to reward his mother for her selfless investment in his college education, Odell begins his journey into the business world. Fulfilling his mission to repay his mother for her personal sacrifices soon becomes challenging as Odell realizes that diversity and individualism are not understood or tolerated in corporate America. Still, even as he faces numerous roadblocks, Odell manages to persevere within a vicious environment of deceit and betrayal where he finds himself constantly struggling to understand the unwritten rules of corporate behavior. But as his destiny leads him into an unknown future, Odell must rely on his wifes strength and his own as his journey comes full circle and takes him to a place he never could have imagined. In this inspirational tale, a courageous black man seeks a new beginning in corporate America where he discovers that achieving success is not easy in the unforgiving world of big business.
Precarious Figurations focuses on the reception of Shakespeare’s The Merchant of Venice in twentieth- and twenty-first-century Germany. Looking at theatrical practices and critical or scholarly discourses from the Weimar Republic to the new millennium, the book explores why the play has served simultaneously as a vehicle for the actualization of anti-Semitic tropes and as a staging ground for the critical exposure of the very logic of anti-Semitism. In particular, the study investigates how the figure of Shylock has come to be both a device in and a stumbling block for attempts to bridge the fundamental rupture in civilization brought about by the Holocaust. The careful analysis of the German reception of Merchant, and in particular of the ways of doing and reading Shylock in the context of painful German, and German-Jewish, discourses of identity and remembrance, is designed to raise fundamental questions – questions concerning not only the staging of Jewishness, the tenacity of anti-Semitism and the difficulties of Holocaust remembrance, but also the general potentials and limitations of theatrical interventions into cultural conflicts.
The Empire of Chance tells how quantitative ideas of chance transformed the natural and social sciences, as well as daily life over the last three centuries. A continuous narrative connects the earliest application of probability and statistics in gambling and insurance to the most recent forays into law, medicine, polling and baseball. Separate chapters explore the theoretical and methodological impact in biology, physics and psychology. Themes recur - determinism, inference, causality, free will, evidence, the shifting meaning of probability - but in dramatically different disciplinary and historical contexts. In contrast to the literature on the mathematical development of probability and statistics, this book centres on how these technical innovations remade our conceptions of nature, mind and society. Written by an interdisciplinary team of historians and philosophers, this readable, lucid account keeps technical material to an absolute minimum. It is aimed not only at specialists in the history and philosophy of science, but also at the general reader and scholars in other disciplines.
This book maintains that the theory of imperialism should incorporate the concept of an “operational code” of political elites to account for agencies’ actions. This concept would explain the strategic continuity and tactical change in US grand strategy from Obama to Trump. While both presidents pursued a strategy of off-shore balancing, their competing worldviews led to tangible differences in the way they sought to restore American power after Bush and to contain the rise of China. This book offers an important contribution after the departure of Bush concluded the 21st century debate on imperialism, at a time when an increasingly post-American world order has undermined the “end of the state” thesis. Indeed, over the last twelve years US grand strategy has emphasized inter-state competition rather than the annihilation of rogue regimes. These events require renewed efforts for the theory of imperialism to contribute to Globalisation Theory at this crucial historical junction.
TERRAINS OF CONSCIOUSNESS emerges from an Indian-German-Swiss research collaboration. The book makes a case for a phenomenology of globalization that pays attention to locally situated socioeconomic terrains, everyday practices, and cultures of knowledge. This is exemplified in relation to three topics: - the tension between 'terrain' and 'territory' in Defoe's 'Robinson Crusoe' as a pioneering work of the globalist mentality (chapter 1) - the relationship between established conceptions of feminism and the concrete struggles of women in India since the 19th century (chapter 2) - the exploration of urban space and urban life in writings on India's capital - from Ahmed Ali to Arundhati Roy (chapter 3).
“Warrior monks”—the misnomer for the Iberian military orders that emerged on the frontiers of Europe in the twelfth century—have long fascinated general readers and professional historians alike. Proposing “ecclesiastical knights” as a more accurate name and conceptual model—warriors animated by ideals and spiritual currents endorsed by the church hierarchy—author Sam Zeno Conedera presents a groundbreaking study of how these orders brought the seemingly incongruous combination of monastic devotion and the practice of warfare into a single way of life. Providing a detailed study of the military-religious vocation as it was lived out in the Orders of Santiago, Calatrava, and Alcantara in Leon-Castile during the first century, Ecclesiastical Knights provides a valuable window into medieval Iberia. Filling a gap in the historiography of the medieval military orders, Conedera defines, categorizes, and explains these orders, from their foundations until their spiritual decline in the early fourteenth century, arguing that that the best way to understand their spirituality is as a particular kind of consecrated knighthood. Because these Iberian military orders were belligerents in the Reconquest, Ecclesiastical Knights informs important discussions about the relations between Western Christianity and Islam in the Middle Ages. Conedera examines how the military orders fit into the religious landscape of medieval Europe through the prism of knighthood, and how their unique conceptual character informed the orders and spiritual self-perception. The religious observances of all three orders were remarkably alike, except that the Cistercian-affiliated orders were more demanding and their members could not marry. Santiago, Calatrava, and Alcantara shared the same essential mission and purpose: the defense and expansion of Christendom understood as an act of charity, expressed primarily through fighting and secondarily through the care of the sick and the ransoming of captives. Their prayers were simple and their penances were aimed at knightly vices and the preservation of military discipline. Above all, the orders valued obedience. They never drank from the deep wellsprings of monasticism, nor were they ever meant to. Offering an entirely fresh perspective on two difficult and closely related problems concerning the military orders—namely, definition and spirituality—author Sam Zeno Conedera illuminates the religious life of the orders, previously eclipsed by their military activities.
This concise text on biologically active substances of the food, pharmaceutical and agricultural industries presents data on natural compounds of vegetable and animal origin. Various nutrients in food, phytochemicals and zoochemicals are discussed, including their uses for prophylactic, metaphylactic and therapeutic purposes in personalized medicine. Along with these compounds, prebiotics isolated by biotechnological methods from plant tissues are reviewed, with the aim of obtaining compounds with an oligoglucide structure. Metabolism of nutrients and the biodegradation of xenobiotics are hot topics and access routes into the human body for the various biologically active substances are covered. Features: Biologically active substances and related chemistry, biochemistry and agrochemistry data are rigorously discussed Data regarding natural compounds of vegetable origin detected from plants present in the spontaneous flora and plants obtained in agricultural crops (medicinal plants, aromatic plants and more) are presented Discusses the natural compounds of animal origin detected in the organisms of some terrestrial and aquatic animals Covers prebiotics isolated by technological and biotechnological methods from plant tissues, with the aim of obtaining compounds with oligoglucide structure Broad audience including all those in biochemistry, the food and pharmaceutical industries and agricultural fields
Third Edition brings acclaimed textthoroughly up to date with the latestorganic coatings technology Organic Coatings, Third Edition is an unparalleled reference and text for organic coatings technology and its myriad applications. It begins with discussions of key principles of coatings, then thoroughly explores raw materials, physical concepts, formulations, and applications. Scientists, engineers, and paint formulators all gain a deeper understanding of the principles underlying the technology and learn how to use these principles in the development, production, and application of organic coatings. The four authors, all leading industry experts, offer a unique approach to the topic that correlates the empirical technology of coatings with the underlying science. This Third Edition has been completely revised and updated to reflect numerous changes in the field, including changes driven by increasing pressure to lower VOC emissions, reduce energy requirements, and eliminate potential health hazards from organic coatings components. In addition, the authors have developed new material to make the text more accessible for scientists and engineers first entering the field, as well as for students taking coatings courses. At the same time, the hallmarks that distinguished the two previous editions have been retained, including: Troubleshooting guidance for coatings scientists and technologists Clear differentiation between established principles and hypotheses requiring further research Precise definitions of coatings industry terminology Extensive references to the current literature Hundreds of figures that help readers visualize key concepts and techniques Whether you are just entering the field of organic coatings and need a broad overview or you are an experienced professional who needs a sophisticated reference, you can depend on Organic Coatings to give you the information and answers you need.
The volume presents the results of a research project (named “Legafight”) funded by the Luxembourg Fond National de la Recherche in order to verify if and how digital tracing applications could be implemented in the Grand-Duchy in order to counter and abate the Covid-19 pandemic. This inevitably brought to a deep comparative overview of the various existing various models, starting from that of the European Union and those put into practice by Belgium, France, Germany and Italy, with attention also to some Anglo-Saxon approaches (the UK and Australia). Not surprisingly the main issue which had to be tackled was that of the protection of the personal data collected through the tracing applications, their use by public health authorities and the trust laid in tracing procedures by citizens. Over the last 18 months tracing apps have registered a rise, a fall, and a sudden rebirth as mediums devoted not so much to collect data, but rather to distribute real time information which should allow informed decisions and be used as repositories of health certifications.
This primer presents the legal framework of the extremely complex regulation of legacy and digital media in Europe by the European Union and the Council of Europe. The volume is divided in five chapters which take into account the European Convention of Human Rights and the Charter of Fundamental Rights of the EU; the regulation of broadcasting; digital communication platforms; data protection in the context of information and communication; and a plurality of other hot topics such as copyright protection, women’s dignity, hate speech and fake news. All the chapters are linked to over 70 decisions of the Strasbourg and Luxembourg courts which are collected in a 300-page Appendix.
Summarizing data on the processes that occur in soil-plant interaction, this text emphasizes the biochemistry and the role of organic compounds in the rhizosphere environment. It considers developments in experimental approaches to the biochemical and molecular interaction among plants, microbes, and soil components.
Discovering the Feminine Genius presents a framework in which women can discover and understand their human and spiritual journey as a daughter of God, a woman, a unique individual, and spouse of the Spirit. Katrina Zeno, renowned speaker on the theology of the body, explores the role of women in our complex world and explains the concept of the feminine genius.
Why This Book? You can learn the most popular frameworks, use the best programming languages, and work at the biggest tech companies, but if you cultivate bad habits, it will be hard for you to become a top developer. This book doesn't offer a straight path or pre-defined formula of success. This book is a result of a quest. A quest to uncover what habits can be cultivated to become a better software engineer. “I wish I had access to this book while I was starting in the software industry. The information presented is not only logical, not only personal, but very well backed up by many expert opinions throughout the book. A must-read, for both beginners and experts alike.” - Zachary Sohovich, Software Engineer at Nike What Will You Read? * How to keep up with all the new technologies * What should you focus? Being a specialist or generalist? * How to stay productive and not feel overwhelmed * The importance of estimating tasks correctly * How to approach new side project ideas * And much more Who Should Read This Book? It doesn't matter if you're a Junior or Senior developer. It doesn't matter how experienced you are. This book can help you cultivate new habits or rethink existing behaviors. What's Inside? This is not a traditional book. You won't find the same format or structure that a regular book has. In fact, this book was designed to be as simple and objective as possible. You can follow the order of chapters, or you can read them individually. Everything is standalone and doesn't depend on previous knowledge. At the end of each chapter, you'll find a section marked as "Questions & Answers", where I interview senior developers and tech leads from various companies to understand how they got there. I went after tech giants such as Google, Amazon, Microsoft, and Adobe. Powerful startups such as GitHub, Spotify, Elastic, Segment, GoDaddy, and Shopify. All the way to established organizations such as Citibank, BlackBerry, and The New York Times. These people come from all over the world and have a pretty diverse background. From San Francisco to New York. From São Paulo to Montreal. From London to Stockholm. The idea is to present you not a one man's point of view, but a collection of insights on how to navigate your career. Who's The Author? Zeno Rocha is a Brazilian creator and programmer. He currently lives in San Francisco, California, where he's the Founder & CEO at Resend. His lifelong appreciation for building software and sharing knowledge led him to speak in over 110 conferences worldwide. His passion for open source put him on the top 20 most active users on GitHub at age 22. Before moving to the US, Zeno developed multiple applications, mentored startups, and worked at major companies in Latin America, such as Globo and Petrobras.
Odell Williams grows up amid a humble background, encouraged by a loving mother who teaches him that working hard and treating people with dignity and respect will bring success. After vowing to make something out of his life to reward his mother for her selfless investment in his college education, Odell begins his journey into the business world. Fulfilling his mission to repay his mother for her personal sacrifices soon becomes challenging as Odell realizes that diversity and individualism are not understood or tolerated in corporate America. Still, even as he faces numerous roadblocks, Odell manages to persevere within a vicious environment of deceit and betrayal where he finds himself constantly struggling to understand the unwritten rules of corporate behavior. But as his destiny leads him into an unknown future, Odell must rely on his wifes strength and his own as his journey comes full circle and takes him to a place he never could have imagined. In this inspirational tale, a courageous black man seeks a new beginning in corporate America where he discovers that achieving success is not easy in the unforgiving world of big business.
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