Tumors often start out as a benign growth, but gradually progress toward the malignant stage over a relatively long period of time. Tumor progression results from accumulated genetic mutations and inheritable epigenetic modifications that enable clonal evolution and selection of new clonal populations of tumor cells with aggressive characteristics including metastasis and therapy resistance. Increasing amounts of experimental evidence suggests that tumor microenvironment play a significant role in directing clonal evolution and determining clonal cell fate, which eventually leads to emergence of malignant tumor cell clones. Hypoxia is the most commonly observed feature of tumor microenvironment. Tumor hypoxia is significantly associated with malignant progression and predicts poor patient outcomes. This book provides detailed and up-to-date treaties on the role of hypoxia as a major driving force in tumor microenvironment to elicit cellular adaptation and clonal selection via genetic mutations and epigenetic modifications, to facilitate cancer stem cell maintenance, to enhance metastasis, to augment therapy resistance, and to evade immune surveillance.
This book provides extensive information on organic-inorganic hybrid materials with controllable compositions and structures developed over the past few decades, including metal sulfonates, carboxylates, phosphonates, metal-organic frameworks (MOFs), etc. A variety of judicious strategies for optimizing mesoporosity are also introduced, aiming at realizing the corresponding superiorities of hybrid frameworks in practical applications at the nano-/meso-scale. The morphological design and modification methods are also described in detail, which extend the potential application range of hybrid materials from traditional areas to high-tech fields. The book offers an ideal reference work for readers in the fields of chemistry, chemical engineering, physics, materials and biology, especially those who are interested in porous hybrid materials. Zhong-Yong Yuan is a Chair Professor at the College of Chemistry, Nankai University, China.
Functioning as both a dense manual, a detailed roadmap, and an edifying tale of spiritual maturity, this third installment in Wang Yun's best-selling series brings you rare and authentic Daoism, straight from the culture that gave birth to it. With clear instruction and dozens of illustrated and filmed exercises, you can begin or strengthen your spiritual practice, boost your immune system, and find deep peace of mind, all right from the comfort of your home. Lofty Daoist philosophy and its practical applications are made easy to grasp and apply through Wang Yun's effort to translate the old teachings on how to apply the mindset and skills of Daoist meditation, alchemy and qigong to all affairs of life. To this end, Returning from Qingcheng Mountain spins a blend of rare tales from Daoist lore, straightforward explanations of ways to shape the body and mind, and inspiring stories from Wang Yun's own practice path. To 'remain natural in all things' is the tenet that pervades every page, an eternal invitation toward being at ease, no matter the circumstances. By doing so, one returns to the world out there and handles mundane matters with poise and efficiency, transforming all the challenges and joys and relationships of daily life into a practice, a meditation, and a chance to grow and develop one's spirit, and by token, the body.
She was tricked into entering the Devil's Cave, but unexpectedly got to know the mysterious Demon Lord. After being reborn into a new life, she had broken off all family ties and embarked on the road to greatness ... However, the road was full of thorns and thistles. There was still Lord Demon Lord causing trouble everywhere."Honored Devil Lord, when did you develop such deep feelings for me?"The Demon Lord smiled sinisterly, "Marry me and I'll tell you.
Like I said, you're just my concubine, not my wife. I'm not married yet, so you should always remember who you are."Qin Shan stopped walking and said with a frown.Madame Xiao had always been the most disciplined person, why would he suddenly ask like that today?Madame Xiao was really unreconciled. Her tears still remained, but they couldn't make Qin Si's heart soften.He did not see much of a woman's tears, but only some of Shui Qin's tears made him feel pity. Madame Xiao was not Shui Qin, even if he lost his voice from crying, Qin Si would not say anything to comfort him."Don't be silly, I don't love you. "Because there's another woman in her heart...
This book is the Magnum Opus dedicated to Mr Chi Yun Chang, a prominent historian as well as the founder of Chinese Culture University. This book illustrates the six elements of Confucius' teachings: Philosophy of Life Ethics, Philosophy of Education, Philosophy of Creation, Political Philosophy, Philosophy of Providence and Philosophy of Peace.The book explains the value and significance of Confucius' teachings and also focuses on the modernization of the teachings. It ascertains that “to understand Confucius is to understand China, the Chinese people, Chinese history and Chinese culture”. This book will be of interest to anyone who is interested in Confucius' teachings and its modern interpretations.
He traveled through ancient and modern societies with space transmigration system, relying on his excellent business ability, he not only gained a lot of wealth but also won the favor of beautiful women. He inadvertently obtained a space-time key, then he could open a door to change time and space as he wishes. He opened a door when living in the modern world, then he would come to the cottage where pirates gathered in ancient times. Open a door in ancient times and then he would return to the familiar modern city. As he kept opening the door to cross, he began to connect the two worlds closely. The ancient gold and silver jewelry was continuously brought to the modern-day by him, and modern glass and plastic became the strange treasures chased by the ancient powers. Since working as a space transmigration businessman, he found that making money was so simple. There are so many people in the modern world who admire his talent and many girls in ancient society vying to be his wife. Isn't life fantastic? ☆About the Author☆ Yun Shisan, an excellent online novelist, has rich creative experience and excellent writing ability. His novel is loved by most readers for its outstanding storyline.
Broken Sky Tower" – as the office building of the consortium that was the leader of the three Major Consortium in Asia and Europe, it had a dazzling splendor that pierced the clouds, similar to its owner's unstoppable imposing aura. Furthermore, its owner, Leng Yiyao, was a legendary figure who hadn't appeared in the business world in a hundred years. The reason why the Leng Family Consortium was so famous in the business world today was all because of this peerless genius.
Since Christianity was re-introduced to China in the early nineteenth century, Chinese Christianity has undergone a holistic “transfiguration” which both truthfully restores ante-Nicene Christianity and successfully adapts to the cultural contexts of Chinese and other societies. The theoretical and theological diversity of this book is consistent with that of traditional Chinese religious writings as well as that of the ante-Nicene fathers but may be deemed un-theoretical, un-academic, or un-theological by those theologians who received Western theological training, as that tends to be too hegemonic, emotionless, and archaic in the eyes of lay believers.
A piece of jade that could topple the world, setting off chaos. The empress dowager's motive for pampering her was unclear, and the emperor's goal for protecting her in every possible way was unclear. Then she would return the favor with an eye, and a tooth for a tooth. She was also the descendant of an illustrious medical family. Furthermore, she had an unknown identity in the dark. Why would she be afraid of their schemes? Her nominal uncle said, "The child is mine. Come with me." The world's most beautiful prince said, "Although the child isn't this king's, this king treats him as if he were his own." However... "Didn't you say the child was yours? And the result? The child has nothing to do with you, and you.
She was a silly and adorable university student, with a vague and lovable personality. He, the Dragon City's ruler, was ruthless, merciless, cold-hearted, and the leader of a mysterious organization. When an accident happened, the silly and adorable her saved her. From then on, a certain man lived a life of unscrupulous affection towards his wife. "CEO, Madam beat him up, the assistant said anxiously." As long as he didn't kill him. The man said coldly. CEO, Madam has taken a fancy to a limited edition bag, the assistant said. Sell all the same to Madame, the man said carelessly. One day, the foolish and cute woman looked at a certain man and asked, "Husband, why are you so good to me?" Because you're my wife. Someone said in a gentle tone. When this girl heard that, she smiled at a certain man and threw herself into his embrace, hugging him tightly. This is a pet for a doting wife, welcome to the pit.
Qin Long's confession had failed. This was his first love, and in the end, it turned out that this girl was actually a gold digger! Damn it, isn't it just love money! If I had money! Qin Long thought angrily. Thus, a bolt of lightning struck him. A voice resounded in his mind while he was unconscious. Ding! Congratulations to the host for obtaining the highest technology, the Most Powerful Posturing System from the O2M star.
This book investigates sisterhood as a converging thread that wove female subjectivities and intersubjectivities into a larger narrative of Chinese modernity embedded in a newly conceived global context. It focuses on the period between the late Qing reform era around the turn of the twentieth century and the outbreak of the Second Sino-Japanese War in 1937, which saw the emergence of new ways of depicting Chinese womanhood in various kinds of media. In a critical hermeneutic approach, Zhu combines an examination of an outside perspective (how narratives and images about sisterhood were mobilized to shape new identities and imaginations) with that of an inside perspective (how subjects saw themselves as embedded in or affected by the discourse and how they negotiated such experiences within texts or through writing). With its working definition of sisterhood covering biological as well as all kinds of symbolic and metaphysical connotations, this book exams the literary and cultural representations of this elastic notion with attention to, on the one hand, a supposedly collective identity shared by all modern Chinese female subjects and, on the other hand, the contesting modes of womanhood that were introduced through the juxtaposition of divergent “sisters.” Through an interdisciplinary approach that brings together historical materials, literary and cultural analysis, and theoretical questions, Zhu conducts a careful examination of how new identities, subjectivities and sentiments were negotiated and mediated through the hermeneutic circuits around “sisterhood.”
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.