Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.
There has never been anything quite like the Cultural Revolution, which disrupted life in the People's Republic of China from 1966 to 1976. It wreaked havoc in the world's most populous country, often turning life upside down and undermining the party, government, and army, weakening the economy, society, and culture. Tens of millions were hurt or killed during this period, and relatively few benefited, aside from Mao Zedong and (temporarily) the Gang of Four." "The A to Z of the Chinese Cultural Revolution provides an extensive chronology that traces the events of the revolution and the introduction puts those events in context and explains them. The bulk of the information is provided in numerous dictionary entries on important persons, places, institutions, and movements. The bibliography points to further resources, and the glossary helps those researching in Chinese." --Book Jacket.
He was in a desperate situation and had fortuitous encounters. From then on, his life was on the line! His brain was well-developed, equipped with superpowers, photographic memory, and extremely intelligent. The students who were at the bottom in the past had entered the university with the status of top scholar. Singing would allow him to become a Heavenly Emperor's superstar, play basketball would allow him to surpass the Hall of Fame, and play games would allow him to defeat the professional tyrants ... All the way back to the sect, glory and wealth came in one body!
As the world’s only English-language historical dictionary of the Chinese Cultural Revolution (1966-1976), this book offers a comprehensive coverage of major historical figures, events, political terms, and other matters relevant to this unique period of modern Chinese history that had profound influence on social and cultural movements of the world in the 1960s and 1970s. This second edition of Historical Dictionary of the Chinese Cultural Revolution covers its history through a chronology, an introductory essay, glossary, and an extensive bibliography. The dictionary section has over 400 cross-referenced entries on important personalities, politics, economy, foreign relations, religion, and culture. This book is an excellent access point for students, researchers, and anyone wanting to know more about this important period in Chinese history.
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