This book contains an introductory and comprehensive account of the theory of (symmetric) Dirichlet forms. Moreover this analytic theory is unified with the probabilistic potential theory based on symmetric Markov processes and developed further in conjunction with the stochastic analysis based on additive functional. Since the publication of the first edition in 1994, this book has attracted constant interests from readers and is by now regarded as a standard reference for the theory of Dirichlet forms. For the present second edition, the authors not only revised the existing text, but also added sections on capacities and Sobolev type inequalities, irreducible recurrence and ergodicity, recurrence and Poincaré type inequalities, the Donsker-Varadhan type large deviation principle, as well as several new exercises with solutions. The book addresses to researchers and graduate students who wish to comprehend the area of Dirichlet forms and symmetric Markov processes.
This book deals with analytic treatments of Markov processes. Symmetric Dirichlet forms and their associated Markov processes are important and powerful tools in the theory of Markov processes and their applications. The theory is well studied and used in various fields. In this monograph, we intend to generalize the theory to non-symmetric and time dependent semi-Dirichlet forms. By this generalization, we can cover the wide class of Markov processes and analytic theory which do not possess the dual Markov processes. In particular, under the semi-Dirichlet form setting, the stochastic calculus is not well established yet. In this monograph, we intend to give an introduction to such calculus. Furthermore, basic examples different from the symmetric cases are given. The text is written for graduate students, but also researchers.
Ghrelin and the ghrelin receptor (GHSR1a) play a central role in growth hormone secretion, food intake, energy metabolism, and other important functions. This book summarizes the present situation of the GHSR1a gene polymorphisms and their genetic effects on growth and fatty acid component traits in domestic animals, humans and rodents. It highlights a unique molecular evolution of the GHSR1a gene among animal species, and its significant genetic and epistatic effects on carcass and fatty acid component traits in a sex-dependent fashion. The volume also shows the overdominance effect of the GHSR1a-DelR242 locus on growth and its molecular mechanisms and the central role of the bovine GHSR1a_5’UTR-(TG) repeat locus in growth and fatty acid component traits in cattle.
To create and establish mutant mice as models for human diseases and traits, various forward and reverse genetics tools are currently available. Newly developed tools of high-throughput identification of novel mutations and site-directed mutagenesis, or gene targeting, in the mouse genome have caused forward and reverse genetics, respectively, to rapidly expand during the last two decades. Worldwide efforts including a variety of international consortiums have been producing many useful mutant mouse strains for functional genomics to elucidate the mechanisms behind diseases and traits. Resource centers and public databases have also been built to enhance their utilities. The modeling has started from Mendelian monogenic traits and has expanded to more complex quantitative traits as well. Multidisciplinary integration among, for example, molecular, cellular, and developmental biology; genetics; genomics; medicine; statistics; and informatics must be orchestrated to fully utilize the resources and knowledge of model mice.
The human drama, and long-term lessons, of the Fukushima nuclear disaster The Fukushima nuclear disaster in March 2011 presented an enormous challenge even to Japan, one of the world's most advanced and organized countries. Failures at all levels—of both the government and the private sector—worsened the human and economic impact of the disaster and ensured that the consequences would continue for many years to come. Based on interviews with more than 300 government officials, power plant operators, and military personnel during the years since the disaster, Meltdown is a meticulous recounting and analysis of the human stories behind the response to the Fukushima disaster. While the people battling to deal with the crisis at the site of the power plant were risking their lives, the government at the highest levels in Tokyo was in disarray and the utility company that operated the plants seemed focused more on power struggles with the government than on dealing with the crisis. The author, one of Japan's most eminent journalists, provides an unrivaled chronological account of the immediate two weeks of human struggle to contain man-made technology that was overwhelmed by nature. Yoichi Funabashi gives insights into why Japan's decisionmaking process failed almost as dramatically as had the Fukushima nuclear reactors, which went into meltdown following a major tsunami. Funabashi uses the Fukushima experience to draw lessons on leadership, governance, disaster resilience, and crisis management—lessons that have universal application and pertinence for an increasingly technology-driven and interconnected global society.
In October 2002 the United States confronted North Korea with suspicions that Pyongyang was enriching uranium in violation of the Agreed Framework that the nations had worked out during the Clinton administration. North Korea subsequently evicted international monitors and resumed its nuclear weapons program. The Peninsula Question chronicles the resulting second Korean nuclear crisis. Japanese journalist Yoichi Funabashi, informed by interviews with more than 160 diplomats and decision makers from China, Japan, Russia, South Korea, and the United States, provides a behind-the-scenes look at the negotiations to denuclearize the peninsula. Between 2002 and 2006, a series of top level diplomats, including the prime minister of Japan, attempted to engage with North Korea. Funabashi illustrates how the individual efforts of these major powers laid the groundwork for multilateral negotiations, first as the trilateral meeting and then as the Six-Party Talks. The first four rounds of talks (2003–2005) resulted in significant progress. Unfortunately, a lack of implementation after that breakthrough ultimately led to North Korea's missile tests in July and subsequent nuclear tests in October 2006. Th e Peninsula Question provides a window of understanding on the historical, geopolitical, and security concerns at play on the Korean peninsula since 2002. Offering multiple perspectives on the second Korean nuclear crisis, it describes more than just the U.S. and North Korean points of view. It pays special attention to China's dealings with North Korea, providing rare insights to into the decision-making processes of Beijing. This is an important, authoritative resource for understanding the crisis in Korea and diplomacy in Northeast Asia.
This book contains an introductory and comprehensive account of the theory of (symmetric) Dirichlet forms. Moreover this analytic theory is unified with the probabilistic potential theory based on symmetric Markov processes and developed further in conjunction with the stochastic analysis based on additive functional. Since the publication of the first edition in 1994, this book has attracted constant interests from readers and is by now regarded as a standard reference for the theory of Dirichlet forms. For the present second edition, the authors not only revised the existing text, but also added sections on capacities and Sobolev type inequalities, irreducible recurrence and ergodicity, recurrence and Poincaré type inequalities, the Donsker-Varadhan type large deviation principle, as well as several new exercises with solutions. The book addresses to researchers and graduate students who wish to comprehend the area of Dirichlet forms and symmetric Markov processes.
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