Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and concludes with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry. Key Features: Causal inference book for clinical statisticians in the pharmaceutical industry Introductory level on the most important concepts and methods Align with FDA and ICH guidance documents Across different stages of clinical studies: plan, design, conduct, analysis, and interpretation Cover a variety of commonly used study designs
When Food Became Scarce is about the Great Leap Famine of 1958-61. Yixin Chen adopts a grassroots level analysis to explore an existential question concerning hundreds of millions of Chinese peasants: why did some peasants perish while others from the same villages facing the same collective problems of food scarcity survive? Viewing the famine as a persistent ordeal, Chen identifies environment and lineage as two pivotal factors that influenced the rural populace's destiny. When food quotas under the Maoist communal dining system plummeted below subsistence or came to a halt, most individual villagers in the mountainous regions of southern China turned to their environment for alternative sustenance, ensuring their survival. More remarkably, across the nation, more peasants united in self-preservation strategies, concealing grains to elude excessive state requisitions, orchestrating food and crop riots, and collectively combating desperation. Given that the majority of Chinese villages were historically established on the foundation of consanguine relationships, creating an obligation among villagers to support one another due to shared ancestry, lineage emerged as a microlevel social mechanism that activated diverse forms of collective resistance. In villages where peasants effectively upheld their lineage organizations and adopted self-protective measures, their survival rates exceeded those of villages where the enforcement of Maoist Great Leap initiatives disrupted the lineage structure, leaving the communities more vulnerable. When Food Became Scare reorients the famine narrative, unpacking its intricacies from the perspective of the survival side.
When Food Became Scarce is about the Great Leap Famine of 1958-61. Yixin Chen adopts a grassroots level analysis to explore an existential question concerning hundreds of millions of Chinese peasants: why did some peasants perish while others from the same villages facing the same collective problems of food scarcity survive? Viewing the famine as a persistent ordeal, Chen identifies environment and lineage as two pivotal factors that influenced the rural populace's destiny. When food quotas under the Maoist communal dining system plummeted below subsistence or came to a halt, most individual villagers in the mountainous regions of southern China turned to their environment for alternative sustenance, ensuring their survival. More remarkably, across the nation, more peasants united in self-preservation strategies, concealing grains to elude excessive state requisitions, orchestrating food and crop riots, and collectively combating desperation. Given that the majority of Chinese villages were historically established on the foundation of consanguine relationships, creating an obligation among villagers to support one another due to shared ancestry, lineage emerged as a microlevel social mechanism that activated diverse forms of collective resistance. In villages where peasants effectively upheld their lineage organizations and adopted self-protective measures, their survival rates exceeded those of villages where the enforcement of Maoist Great Leap initiatives disrupted the lineage structure, leaving the communities more vulnerable. When Food Became Scare reorients the famine narrative, unpacking its intricacies from the perspective of the survival side.
Causal Inference in Pharmaceutical Statistics introduces the basic concepts and fundamental methods of causal inference relevant to pharmaceutical statistics. This book covers causal thinking for different types of commonly used study designs in the pharmaceutical industry, including but not limited to randomized controlled clinical trials, longitudinal studies, singlearm clinical trials with external controls, and real-world evidence studies. The book starts with the central questions in drug development and licensing, takes the reader through the basic concepts and methods via different study types and through different stages, and concludes with a roadmap to conduct causal inference in clinical studies. The book is intended for clinical statisticians and epidemiologists working in the pharmaceutical industry. It will also be useful to graduate students in statistics, biostatistics, and data science looking to pursue a career in the pharmaceutical industry. Key Features: Causal inference book for clinical statisticians in the pharmaceutical industry Introductory level on the most important concepts and methods Align with FDA and ICH guidance documents Across different stages of clinical studies: plan, design, conduct, analysis, and interpretation Cover a variety of commonly used study designs
Aqueous Zinc Ion Batteries Pioneering reference book providing the latest developments and experimental results of aqueous zinc ion batteries Aqueous Zinc Ion Batteries comprehensively reviews latest advances in aqueous zinc ion batteries and clarifies the relationships between issues and solutions for the emerging battery technology. Starting with the history, the text covers essentials of each component of aqueous zinc ion batteries, including cathodes, anodes, and electrolytes, helping readers quickly attain a foundational understanding of the subject. Written by three highly qualified authors with significant experience in the field, Aqueous Zinc Ion Batteries provides in-depth coverage of sample topics such as: History, main challenges, and zinc metal anodes for aqueous zinc ion batteries Electrochemical reaction mechanism of aqueous zinc ion batteries and interfacial plating and stripping on zinc anodes Cathode materials for aqueous zinc ion batteries, covering manganese-based materials, vanadium-based materials, Prussian blue analogs, and other cathode materials Development of electrolytes, issues, and corresponding solutions for aqueous zinc ion batteries Separators for aqueous zinc ion batteries, development of full zinc ion batteries, and future perspectives on the technology A detailed resource on a promising alternative to current lithium-ion battery systems, Aqueous Zinc Ion Batteries is an essential read for materials scientists, electrochemists, inorganic chemists, surface chemists, catalytic chemists, and surface physicists who want to be on the cutting edge of a promising new type of battery technology.
Microgrid Methodologies and Applications provides step-by-guide guidance on the implementation of microgrids projects that is informed by current scientific principles, emergent technologies such as modern power electronic interfaces, energy storage systems, multi-vector energy systems, and a close study of recent case studies. Addressing the full end-to-end microgrid project lifecycle, the work encompasses planning, design, operation, control, trading and evaluation, with a significant focus on novel business model, regulation and policy considerations. The book explains to readers how they can operationalize robust microgrids which account for engineering reality, uncertainties, and operating constraints. It delivers precise and rigorous real case studies for project managers, designers and policy and decision-makers. The methodologies section provides step-by-step guidance on implementing projects for postgraduate students, researchers and practitioners, while the applications section provides an array of demonstrative ‘case studies which exemplify the use of optimal methods and leading-edge technologies. Provides step-by-step guidance on the design, operation, control, trading and evaluation of microgrid projects Demystifies real-world project experience through the evaluation of successful case studies, novel data analysis and comprehensive evaluation rather than cumbersome mathematical formulations Combines theoretical and practical insights, serving to bridge gaps between theory and engineering operations, control and decision-making Reviews state-of-the-art topics including business models, trading strategies, pricing, regulatory standards and policy recommendations poised to profoundly affect local energy transitions and utilization of microgrids
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