Twin Soul Bodies. One was like a golden sun, making it impossible for people to look directly at it. The other was like a star in the night. It was brilliant and dazzling. Relying on his determination, he stepped into dangerous areas, trained his physical body, accompanied by his beauties. After changing his fate, he beheaded evil spirits, killed tens of thousands of demons, rose to prominence amongst the human race, and made friends with drunk brothers.
A balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to all phases of clinical trial design. Before underpinning various adaptive methods, the book establishes an overview of the fundamentals of clinical trials as well as a comparison of Bayesian and frequentist statistics. Recognizing that clinical trial design is one of the most important and useful skills in the pharmaceutical industry, this book provides detailed discussions on a variety of statistical designs, their properties, and operating characteristics for phase I, II, and III clinical trials as well as an introduction to phase IV trials. Many practical issues and challenges arising in clinical trials are addressed. Additional topics of coverage include: Risk and benefit analysis for toxicity and efficacy trade-offs Bayesian predictive probability trial monitoring Bayesian adaptive randomization Late onset toxicity and response Dose finding in drug combination trials Targeted therapy designs The author utilizes cutting-edge clinical trial designs and statistical methods that have been employed at the world's leading medical centers as well as in the pharmaceutical industry. The software used throughout the book is freely available on the book's related website, equipping readers with the necessary tools for designing clinical trials. Clinical Trial Design is an excellent book for courses on the topic at the graduate level. The book also serves as a valuable reference for statisticians and biostatisticians in the pharmaceutical industry as well as for researchers and practitioners who design, conduct, and monitor clinical trials in their everyday work.
Since the beginning of the 21st century, China has been experiencing a dramatically rapid economic development. What is the real life of Chinese people like under China’s steady GDP fast growth? How rich are the rich and how poor are the poor? This book provides first-hand data on standards of living in Chinese households, which may help to answer the above questions. The Survey and Research Center for China Household Finance conducted the first and only nationally representative survey on household finance in China in 2011. The China Household Finance Survey (CHFS) collected the micro-level information of Chinese households’ demographics, housing and financial assets, debt and credit constraints, income and expenditures, social welfare and insurance, intergenerational transfer payments, employment and payment habits. Readers will receive a vivid picture of wealth disparity, real estate market developments, social welfare status, household financial behaviors and other economic issues in today’s China. The China Household Finance Survey has a guiding significance for a realistic strategy adjustment and is also a major breakthrough in the subject’s development at universities. Li Daokui, Professor at Tsinghua University. The China Household Finance Survey (CHFS) is an in-house interview survey with a large influence in China. The CHFS's sample includes both urban and rural households, which is very important to the study of the overall household finance of China. Hongbin Li, Economist, Professor of Tsinghua University. Research Report of China Household Finance Survey•2012 bridges a major gap in the household finance field in China, and will have far-reaching academic and policy-making implications. Liu Yuzhen, Professor at Peking University.
Qin Yuan was a natural gay, and he fell in love with Zhao Chengyu at first sight. When he was down and out, Zhao Chengyu helped him step onto the path of both acting and singers. His feelings for him became more and more unruly. Cohabitation, the temptation of pajamas, the strategy of gourmet food, all of them were no problem. And to see how the Aoife Singer teases Lord Shadow Emperor one step at a time.
The book reports on the development of household finances in rural China. It is based on the results of an on-site survey conducted door to door by a research team from the Survey and Research Center for China Household Finance, the largest survey center in China – and perhaps the world – that specializes in Chinese household finances. Directed by financial experts that enjoy the highest honors in their field and the largest interviewer group in China, it reveals the most realistic picture of rural China available today and highlights a topic about which people worry most: household finances. By reading this inspiring report, readers will be able to better understand China from a household finance perspective.
Nonlinear diffusion equations, an important class of parabolic equations, come from a variety of diffusion phenomena which appear widely in nature. They are suggested as mathematical models of physical problems in many fields, such as filtration, phase transition, biochemistry and dynamics of biological groups. In many cases, the equations possess degeneracy or singularity. The appearance of degeneracy or singularity makes the study more involved and challenging. Many new ideas and methods have been developed to overcome the special difficulties caused by the degeneracy and singularity, which enrich the theory of partial differential equations.This book provides a comprehensive presentation of the basic problems, main results and typical methods for nonlinear diffusion equations with degeneracy. Some results for equations with singularity are touched upon.
This book presents China’s wealth management market to the public, institutions and research groups. As the money base of Renminbi (RMB or Chinese Yuan) from the central bank increases exponentially in recent years, the overall leverage ratio rises in an alarming rate and the shadow banking issues stick out. Where this massive amount goes has raised huge interest all over the world. This book answers this question in three aspects: What is the money made up? Who is managing the money and how are they doing? The author studied six types of financial institutions that are responsible for channeling the money to industries and individuals. Banks although still the main vehicle for money flows, other financial organizations have taken more and more important roles in the money management market. Insurance, trust, security and mutual funds are the main non-banking business participants. New money management products are innovated, as are the regulations. The money management business in China has experience from starting chaos to a regulated market and the evolution is still going on. Professionals and researchers around the world are watching China’s money market closely, studying the mechanisms, looking for business opportunities and trying to theorizing economic rules. This book is a well presented and professionally structured for the above purposes.
Eileen Yin-Fei Lo, author of award-winning cookbooks, menu developer for top Asian restaurants, and cooking teacher, presents her life's work. Reflecting on her life in food, including her childhood in Canton, China, where she learned to cook at her grandmother's side, Eileen has created an exhaustive cookbook of extensive scope. Everything about Chinese cooking has cultural significance, and much of what Eileen talks about in this book has never appeared in print before in the English language. There are more than 250 recipes in all, including many classic banquet-style recipes, quite a number presented for the first time in the traditional manner, from Peking Duck to Beggar's Chicken. Dozens of the techniques for preparing these elaborate recipes are shown in full-color photographs in the color insert as well. Eileen also includes many of her own creations, such as infused oils and rich, flavorful stocks, essential for cooks who are serious about mastering the ancient art of Chinese cooking. Everything is here: dim sum, congees, stir-fries, rice dishes, noodles, bean curd, meat dishes, and more. For anyone who loves Asian cuisines, this is the ultimate cookbook, and for cookbook lovers and aspiring food professionals, this is required reading.
In Politics of Art Zhiguang Yin investigates members of the Creation Society and their social network while in Japan. The study contextualises the Chinese left-wing intellectual movements and their political engagements in relation with the early 20th century international political events and trends in both East Asia and Europe. The Creation Society was largely viewed as a subject of literary studies. This research, however, evaluates these intellectuals in the context of Chinese revolution and elaborates their theoretical contribution to the Chinese Communist Party’s practice of “theoretical struggle” as a main driving force of ideological construction. As this study tries to demonstrate, theoretical struggle drives the ideological politics forward while maintaining its political vigour.
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