In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.
This handbook offers timely investigation of current pharmaceutical trends, clinical guidelines, novel treatments, and ongoing pipeline developments, including ground-breaking advances in the use of novel oral anticoagulants. Atrial fibrillation (AF) affects an estimated 1–2% of the population and is the most common cause of sustained cardiac arrhythmia. Critically, the number of patients developing AF is expected to double in the next five decades, leading to increased incidence of stroke, heart failure and other serious thromboembolic events.
The story of Penang would be incomplete without the Big Five Hokkien families (the Khoo, the Cheah, the Yeoh, the Lim, and the Tan). It was the Big Five who played a preponderant role not only in transforming Penang into a regional entrepot and a business and financial base, but also in reconfiguring maritime trading patterns and the business orientation of the region in the nineteenth century. Departing from the colonial vantage point, this book examines a web of transnational, hybrid and fluid networks of the Big Five comprising of family relationship, sworn brotherhood, political alliance and business partnerships, which linked Penang and its surrounding states (western Malay states, southwestern Siam, southern Burma, and the north and eastern coasts of Sumatra) together to form one economically unified geographical region, having inextricable links to China and India. With these intertwining networks, the Big Five succeeded in establishing their dominance in all the major enterprises (trade, shipping, cash crop planting, tin mining, opium revenue farms), which constituted the linchpin of Penang's and its region's economy. By disentangling and dissecting this intricate web of networks, this book reveals the rise and decline of the Hokkien mercantile families' nearly century-long economic ascendancy in Penang and its region."e;Wong Yee Tuan's study of the five clans of Penang represents a major breakthrough in the study of the Malayan Chinese. He documents an extremely important aspect of the nineteenth-century Asian diaspora, exposing the intricate links between families, businesses, secret societies, revenue farms and public life of some of the key groups of Chinese in Penang and northern Malaya. The book weaves together the various strands of overseas Chinese life not only in Malaya, but also in the Netherlands Indies, Siam and China. Most importantly, it shows the process by which the Chinese leaders gained political, economic and social power as well as the way by which these powers were lost."e;- Carl A. Trocki, Emeritus Professor, Asian Studies, Queensland University of Technology, Australia"e;This volume can be situated within a growing historiographical current whereby regional studies of connections, networks and interactions are gradually transcending national histories. Incorporating commercial, ethnic and social elements, the history presented can be concurrently seen as a business case study, a sociological exploration, a political economy treatise and an inquiry into Hokkien networking. Wong Yee Tuan is to be congratulated on this signal study in how local, national and broader regional histories can be integrated."e;- Geoffrey Wade, ANU College of Asia and the Pacific, Australian National University"e;By aligning family, socio-political and business interests, the leading Penang Hokkien clans centralized their 'home port' as a hub of regional commercial networks, thus successfully extending the trading colonies of Chinese diaspora westward to the edge of the Indian Ocean. Wong has fastidiously researched and compellingly proven this, with a clear eye for relevant cross-cultural collaborations with indigenous and international actors. The important legacy of the 'Big Five' clanhouses is now firmly embedded in the George Town World Heritage Site, inciting further inquiry into the cultural formation of collective entrepreneurship in Southeast Asia."e;- Khoo Salma Nasution, Heritage Advocate and Local Historian, Penang
Standards, Quality Control and Measurement Sciences in 3D Printing and Additive Manufacturing addresses the critical elements of the standards and measurement sciences in 3D printing to help readers design and create safe, reliable products of high quality. With 3D printing revolutionizing the process of manufacturing in a wide range of products, the book takes key features into account, such as design and fabrication and the current state and future potentials and opportunities in the field. In addition, the book provides an in-depth analysis on the importance of standards and measurement sciences. With self-test exercises at the end of each chapter, readers can improve their ability to take up challenges and become proficient in a number of topics related to 3D printing, including software usage, materials specification and benchmarking. - Helps the reader understand the quality framework tailored for 3D printing processes - Explains data format and process control in 3D printing - Provides an overview of different materials and characterization methods - Covers benchmarking and metrology for 3D printing
To most cardiologists, the long QT syndrome is a relatively rare congenital and familial syndrome that affects children or young adults. However, in addition to congenital LQTS there is a series of acquired forms of the syndrome, usually resulting from exposure to drugs that extend the duration the QT interval. This prolongation may be the primary pharmacodynamic action of the drug, however a plethora of other drugs, including some types of antibiotic, antipsychotics, antidepressants, antimalarials and antihistamines may provoke QT interval prolongation. The aim of the Clinical Approaches to Tachyarryhthmias series is to update the physician, cardiologist, and all those responsible for the the care of patients with cardiac arrhythmias. In this volume, Dr. Yap and Dr. Camm expose the data implicating a large number of drugs as potential QT prolongators.
In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.
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