Total joint replacement (TJR) is one of the success stories of modern medicine, which has reliably provided dramatic pain relief and improved the quality of life for several million patients with a destructive end-stage joint disease. However, the main long-term complication of TJR surgery is prosthetic loosening, often combined with osteolysis following wear, corrosion and failure of the implant. Over the past decade, the biological interactions between various types of wear particles and metal ions from metal-on-polyethylene (MoPE), metal-on-metal (MoM) and ceramic-on-ceramic (CoC) implants, endogenous danger signals (alarmins) and/or bacterial components of the microbiome with the innate and adaptive host defence (immune) system, have become better known. In this chapter, we discuss the role of biomaterials and implant-derived wear and corrosion debris in loosening of TJRs, with particular emphasis on MoM total hip replacements (THR) and hip resurfacing arthroplasty (HRA).
Total joint replacement (TJR) is one of the success stories of modern medicine, which has reliably provided dramatic pain relief and improved the quality of life for several million patients with a destructive end-stage joint disease. However, the main long-term complication of TJR surgery is prosthetic loosening, often combined with osteolysis following wear, corrosion and failure of the implant. Over the past decade, the biological interactions between various types of wear particles and metal ions from metal-on-polyethylene (MoPE), metal-on-metal (MoM) and ceramic-on-ceramic (CoC) implants, endogenous danger signals (alarmins) and/or bacterial components of the microbiome with the innate and adaptive host defence (immune) system, have become better known. In this chapter, we discuss the role of biomaterials and implant-derived wear and corrosion debris in loosening of TJRs, with particular emphasis on MoM total hip replacements (THR) and hip resurfacing arthroplasty (HRA).
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