Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches Caco-2 cell culture model, MDCK, and other related cell culture models which are used to study the science of oral bioavailability.
For Hua Yanqing, who had lost his memory after transmigration and was tricked by the trash of a male into having his braids sticking out, the heavens were definitely playing with her! However, since he had been reborn, he had to settle the score. It was time for him to take revenge, right? Trash man and woman, slag father and mother ... All sorts of scum, no one can even think of escaping! But, with just a little carelessness, how did he end up with Third Uncle Ao Jiao, who was rumored to have great ability? You still want to help him settle his life's important matters? Third Uncle, this is a portrait of my beauty in the entire city. Pick one! My Uncle: No need. Third Uncle thinks that it's good enough for you, little niece ...
This book provides a comprehensive introduction on opinion analysis for online reviews. It offers the newest research on opinion mining, including theories, algorithms and datasets. A new feature presentation method is highlighted for sentiment classification. Then, a three-phase framework for sentiment classification is proposed, where a set of sentiment classifiers are selected automatically to make predictions. Such predictions are integrated via ensemble learning. Finally, to solve the problem of combination explosion encountered, a greedy algorithm is devised to select the base classifiers.
Intelligent Biomechatronics in Neurorehabilitation presents global research and advancements in intelligent biomechatronics and its applications in neurorehabilitation. The book covers our current understanding of coding mechanisms in the nervous system, from the cellular level, to the system level in the design of biological and robotic interfaces. Developed biomechatronic systems are introduced as successful examples to illustrate the fundamental engineering principles in the design. The third part of the book covers the clinical performance of biomechatronic systems in trial studies. Finally, the book introduces achievements in the field and discusses commercialization and clinical challenges. As the aging population continues to grow, healthcare providers are faced with the challenge of developing long-term rehabilitation for neurological disorders, such as stroke, Alzheimer's and Parkinson's diseases. Intelligent biomechatronics provide a seamless interface and real-time interactions with a biological system and the external environment, making them key to automation services. - Written by international experts in the rehabilitation and bioinstrumentation industries - Covers the current understanding of nervous system coding mechanisms, which are the basis for biological and robotic interfaces - Demonstrates and discusses robotic rehabilitation effectiveness and automatic evaluation
This book enriches the evolving concept of soft power, and China’s approach to soft power, by considering how aspects of Chinese culture, notably the traditional martial art and health promoting exercise Tai Chi Quan, are being successfully promoted around the world by non-state actors, and how this fits alongside China’s state-sponsored soft power promotion. The book contrasts growing soft power promotion by China with the corresponding decline in such activities by Western states, outlines the growth of Tai Chi Quan societies worldwide and explores in detail why Tai Chi Quan appeals so strongly outside China. It shows how Tai Chi Quan introduces many people around the world to Chinese culture and builds links between people inside China and elsewhere in the world. It concludes that Tai Chi Quan achieves what soft power aims to achieve: a good image and long-term friendship.
The book mainly describes the QTL mappings and efficacy analyses that are associated with wheat productivity, quality, physiology and various stress resistances and provides summaries of results from studies conducted both at home and abroad. It presents comparable data and analyses, helping readers to arrive at a more comprehensive understanding of the latest development in this field. The book provides a wealth of novel information, broad range of applications and in-depth findings on crop genetics and molecular breeding, making it valuable not only for plant breeders but also for academic faculties, senior researchers and advanced graduate students who are involved in plant breeding and genetics. Dr. Jichun Tian is a professor at the Department of Agronomy, Shandong Agricultural University, Tai’an, China.
This unique compendium provides a novel research on how time influences the conversions of advertising and product recommendation in E-commerce. It proposes time-aware conversion prediction models to solve the problem — what products should be recommended for a given period to maximize conversion? The volume also presents a series of researches on how to build data-driven attribution models to allocate the time-sensitive contribution of advertisements to the conversion. This must-have reference text will be invaluable for researchers, professionals, academics and graduate students keen in databases and artificial intelligence.
This book examines different dynamics such as marketisation, globalisation and new media technologies that have driven the transformation of China''s media industry OCo one of the primary battlegrounds where ideological, social and economic struggles are fought OCo against the backdrop of the growing tensions between economic growth, globalisation, and political control in China.
This book examines different dynamics such as marketisation, globalisation and new media technologies that have driven the transformation of China's media industry — one of the primary battlegrounds where ideological, social and economic struggles are fought — against the backdrop of the growing tensions between economic growth, globalisation, and political control in China.
This book examines the sustainability transition theory in the context of urbanization in China, tracing the development of eco and low-carbon cities. It examines how ideas on building eco-cities and low-carbon cities travel from nation to nation, how they are adopted in the Chinese administrative context and what role inter-scalar actors play in getting the ideas transferred, translated and operationalized on the ground. Offering an overarching theoretical framework that incorporates all urban sustainability experiments in China, the book conducts a comprehensive analysis of the master plans of these new towns and summarizes the normative transition targets of sustainable urban experiments. It explores how they differ from each other and how they influence transition dynamics in practice. By examining four eco and low-carbon new towns deemed representative of current major approaches to sustainability transition management in China, the book provides a detailed depiction of generic transition management and explains the different transitional trajectories for each type of sustainable urban experiment. It demonstrates how subnational-level and city-level transitions mediate the national transition. Through a thorough inquiry into inter-scalar dynamics, institutional arrangements and techno-social innovations in sustainable urban experiments, the book links generalized transition rules and specific contexts to present a full view of the challenges, failures and territorial problems of eco and low-carbon new towns. This book makes a novel contribution to the study of Chinese urbanization by revisiting issues and problems of contemporary urban China. The reflection on these urban issues will provide implications to policymakers, professionals and the common reader interested in the future sustainable urbanism in China.
This book mainly deals with grassland digitalization and recognition through computer vision, which will make contributions to implement of grass auto recognition and data acquisition. Taking advantage of computer vision, it focuses on intrinsic feature extraction to realize the functions such as auto recognition of forage seeds and microscope images mosaic. The book presents a new approach for identification of grass seeds, with clear figures and detailed tables. It enlightens reader by solving the traditional problems of pratacultural science through the aid of computer science.
As a distinctive syntactic structure in Mandarin Chinese, the Patient-Subject Construction (PSC) is one of the most interesting but least well-understood structures in the language. This book offers a comprehensive account of the history, structure, meaning and use of the PSC. Unlike previous descriptions which were framed in terms of pre-existing grammatical notions such as ‘topicalization’, ‘passivization’ and ‘ergativization’, this book offers a fresh look at the PSC, in which its syntactic and semantic as well as its discourse functions are examined within the system of major construction-types of the language as a whole. The PSC, being low in transitivity, serves primarily the function of backgrounding in discourse. Typologically, the PSC bears a resemblance to middle constructions in Indo-European and other languages, raising interesting questions about ways to understand congruent and divergent syntactic structures across the world’s languages. This book will be of interest to students of Chinese Linguistics as well as Language Typology.
Focusing on the poetry and cultural practice of Frank O’Hara, the great urban poet of the New York School during the 1950s and 1960s, this books explores the interwoven relationship between his urban poetics and the urban culture of New York, seeking to shed light on poetic concept and its cultural relevance. The poetry of Frank O’Hara is deeply rooted in and nourished by his urban experience as a metropolitan and an active participant in the vibrant cultural scene of New York. Therefore, an investigation into the interactive dynamics between his poetry and the urban culture he helped shape serves as a starting point for further study on the literary representation of European and American urban culture. Across eight chapters, the authors look into the genesis, theoretical constitution, the interface with culture and aesthetics of O’Hara’s urban poetics and also their philosophical foundations, literary ethics, special expression and representation as well as his reception of modernity and postmodernity. The title will appeal to scholars, students and general readers interested in American literature, poetry and urban culture, especially Frank O’Hara and the New York School.
Hangzhou is a very special city for Italian architects who want to learn about historical and contemporary architecture and about the urban challenges in contemporary China. There are further issues that we would like to investigate about Hangzhou in the future and in order to do that, it would be interesting to involve further experts such as archaeologists and hydrologists given the special presence of historical relics, water and several issues which still deserve a better enhancement.
Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.
What part does customer and employee satisfaction play in overall business success? Management Accountants developing business models must consider this question, especially if they are taking the popular "balanced scorecard" or "strategy mapping" approaches to performance measurement. When doing so, stating cause-and-effect relationships between measurable factors like satisfaction and profitability is common practice. However, few companies test their own hypotheses. If the links are incorrect, these models can actually guide the firm down a path to failure. Strategy Mapping: An Interventionist Examination of a Homebuilder's Performance Measurement and Incentive Systems reveals the findings of state-of-the-art interventionist research on a major US homebuilder. The core claims of this company's business model were positive effects in the future due to improvements in customer and employee satisfaction. Tests were made on the validity of these claims to discover how much we can rely on these factors to improve performance. This report also examines how effective various measurement alternatives are through analysis of data compiled by different consulting companies. The results reveal that the links between satisfaction and performance is less strong and more complex than the company had assumed: these measures cannot be relied upon to guarantee increased performance. Managers must have a sophisticated understanding of performance measurement systems and to test their strategy maps empirically, rather than relying on their intuitions. This report demonstrates how you can achieve both. State-of-the-art interventionist research: new method in which researchers interact with the subject of the research, monitoring the effects of their input Helps managers protect their businesses from bad business models through sophisticated understanding of likely causes of success Shows managers how to analyse data in balanced scorecards and strategy maps to draw reliable conclusions to make the best decisions for their business
This book enriches the evolving concept of soft power, and China’s approach to soft power, by considering how aspects of Chinese culture, notably the traditional martial art and health promoting exercise Tai Chi Quan, are being successfully promoted around the world by non-state actors, and how this fits alongside China’s state-sponsored soft power promotion. The book contrasts growing soft power promotion by China with the corresponding decline in such activities by Western states, outlines the growth of Tai Chi Quan societies worldwide and explores in detail why Tai Chi Quan appeals so strongly outside China. It shows how Tai Chi Quan introduces many people around the world to Chinese culture and builds links between people inside China and elsewhere in the world. It concludes that Tai Chi Quan achieves what soft power aims to achieve: a good image and long-term friendship.
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