Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells.
Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets, which consists of two major components. First, due to malfunctioning axonal guidance, a muscle gets reinnervated by a "foreign" axon, that has been misrouted along a "wrong" fascicle. Second, the supernumerary collateral branches emerging from all transected axons simultaneously innervate antagonistic muscles and cause severe impairment of their coordinated activity. Since it is hardly possible to influence the first major component and improve the guidance of several thousands axons, the authors concentrated on the second major component and tried to reduce the collateral axonal branching.
This investigation is concerned with the ultracytochemistry of glycoconjugates - i. e., the carbohydrate moieties of glycoproteins and glycolipids - attached to intracellular post-Golgi membranes (membranes of lysosomes, peroxisomes, secretory granules of exocrine and endocrine gland cells). In addition mitochon dria have been studied. There are at present very few cytochemical studies, none of them systematic, on intracellular membrane-bound glycoconjugates. So far it has only been re ported that phosphotungstic acid (PTA) at low pH (pH
Facial nerve surgery inevitably leads to partial pareses, abnormally associated movements and pathologically altered reflexes. The reason for this "post-paralytic syndrome" is the misdirected reinnervation of targets, which consists of two major components. First, due to malfunctioning axonal guidance, a muscle gets reinnervated by a "foreign" axon, that has been misrouted along a "wrong" fascicle. Second, the supernumerary collateral branches emerging from all transected axons simultaneously innervate antagonistic muscles and cause severe impairment of their coordinated activity. Since it is hardly possible to influence the first major component and improve the guidance of several thousands axons, the authors concentrated on the second major component and tried to reduce the collateral axonal branching.
This investigation is concerned with the ultracytochemistry of glycoconjugates - i. e., the carbohydrate moieties of glycoproteins and glycolipids - attached to intracellular post-Golgi membranes (membranes of lysosomes, peroxisomes, secretory granules of exocrine and endocrine gland cells). In addition mitochon dria have been studied. There are at present very few cytochemical studies, none of them systematic, on intracellular membrane-bound glycoconjugates. So far it has only been re ported that phosphotungstic acid (PTA) at low pH (pH
Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells.
This book is a profound reexamination of the role of the German army, the Wehrmacht, in World War II. Until very recently, the standard story avowed that the ordinary German soldier in World War II was a good soldier, distinct from Hitler's rapacious SS troops, and not an accomplice to the massacres of civilians. Wolfram Wette, a preeminent German military historian, explodes the myth of a "clean" Wehrmacht with devastating clarity. This book reveals the Wehrmacht's long-standing prejudices against Jews, Slavs, and Bolsheviks, beliefs that predated the prophecies of Mein Kampf and the paranoia of National Socialism. Though the sixteen-million-member German army is often portrayed as a victim of Nazi mania, we come to see that from 1941 to 1944 these soldiers were thoroughly involved in the horrific cleansing of Russia and Eastern Europe. Wette compellingly documents Germany's long-term preparation of its army for a race war deemed necessary to safeguard the country's future; World War II was merely the fulfillment of these plans, on a previously unimaginable scale. This sober indictment of millions of German soldiers reaches beyond the Wehrmacht's complicity to examine how German academics and ordinary citizens avoided confronting this difficult truth at war's end. Wette shows how atrocities against Jews and others were concealed and sanitized, and history rewritten. Only recently has the German public undertaken a reevaluation of this respected national institution--a painful but necessary process if we are to truly comprehend how the Holocaust was carried out and how we have come to understand it.
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