It has only been recognised tardily and with reluctance that during the Second World War hundreds of thousands of itinerants met the same horrendous fate as Jews and other victims of Nazism. Gypsies appear to appeal to the imagination simply as social outcasts and scapegoats or, in a flattering but no more illuminating light, as romantic outsiders. In this study, contemporary notions about Gypsies are traced back as far as possible to their roots, in an attempt to lay bare why stigmatisation of gypsies, or rather groups labelled as such, has continuned from the distant past even to today.
In this volume the authors present an alternative approach to the history of gypsies and travelling groups in western Europe. By focusing on processes of social construction, stigmatization and categorization, they offer new insights into the development of government policies towards itinerants in general and the ethnicization of some of these groups in particular. They analyze the western images and representations of gypsies and other itinerant groups, at the same time focusing on their functions for the labour market. By doing so, they add a new chapter to the field of social history.
Less than 50 years ago it was discovered that steady-state protein concentrations in plasma are the net result of continuous elimination and synthesis of protein molecules. The first quanti tative studies on the turnover and distribution of plasma pro teins were made around 1950, after the introduction of radio labeled protein preparations. Around 1970, another development in quantitative interpre tation of circulating proteins was initiated in clinical enzy mology. Estimation of cumulative release into plasma of cellular enzymes can be helpful in a variety of diseases to assess the extent of tissue damage and to evaluate therapy. Enzymes can be considered as biological tracers, i.e. minute quantities of protein can be accurately determined by their spe cific catalytic activities. However, radioactive tracers permit direct estimates of turnover and distr ibution by measurement of excreted radioactivity, possibilities that are not available for enzymes. Consequently, only a few techniques used in tracer studies with radiolabeled proteins can be applied to circulating tissue enzymes and this may explain the lack of communication between the fields of plasma protein metabolism and quantitative clinical enzymology. In the present study a summary is given of the basic methods used in both fields, with emphasis on the equivalence of various models and formalisms used by different authors. It is shown that major limitations in the study of circulating tissue enzymes can be overcome if two different, but simultaneously released, en zymes can be measured. The resulting method will also be applied to plasma protein metabolism.
In this volume the authors present an alternative approach to the history of Gypsies and Travelling Groups in Western-Europe. By focusing on processes of social construction, stigmatization and categorization, they offer new insights into the development of government policies towards itinerants in general and the ethnicization of some of these groups in particular. They analyze the Western images and representations of Gypsies and other itinerant groups, at the same time focusing on their functions for the labor market. By doing so, they add a new chapter to the field of social history.
It has only been recognised tardily and with reluctance that during the Second World War hundreds of thousands of itinerants met the same horrendous fate as Jews and other victims of Nazism. Gypsies appear to appeal to the imagination simply as social outcasts and scapegoats or, in a flattering but no more illuminating light, as romantic outsiders. In this study, contemporary notions about Gypsies are traced back as far as possible to their roots, in an attempt to lay bare why stigmatisation of gypsies, or rather groups labelled as such, has continuned from the distant past even to today.
In this volume the authors present an alternative approach to the history of gypsies and travelling groups in western Europe. By focusing on processes of social construction, stigmatization and categorization, they offer new insights into the development of government policies towards itinerants in general and the ethnicization of some of these groups in particular. They analyze the western images and representations of gypsies and other itinerant groups, at the same time focusing on their functions for the labour market. By doing so, they add a new chapter to the field of social history.
1997 was an important year for Sint Janskerk in Gouda, as the Museo del Prado in Madrid asked to borrow the cartoon of the King's Window by Dirck Crabeth for the exhibition 'Felipe II. Un príncipe del Renacimiento'. Inspired by this event, it was decided to compile an anthology about the church's seventh window. Based on the many-facetted topic an international group of scholars from various disciplines studied the stained-glass window in depth as a crucial presentation of Philip II's Netherlandish and English years. An important step in current research into an enthralling era in European history of the sixteenth century.
Less than 50 years ago it was discovered that steady-state protein concentrations in plasma are the net result of continuous elimination and synthesis of protein molecules. The first quanti tative studies on the turnover and distribution of plasma pro teins were made around 1950, after the introduction of radio labeled protein preparations. Around 1970, another development in quantitative interpre tation of circulating proteins was initiated in clinical enzy mology. Estimation of cumulative release into plasma of cellular enzymes can be helpful in a variety of diseases to assess the extent of tissue damage and to evaluate therapy. Enzymes can be considered as biological tracers, i.e. minute quantities of protein can be accurately determined by their spe cific catalytic activities. However, radioactive tracers permit direct estimates of turnover and distr ibution by measurement of excreted radioactivity, possibilities that are not available for enzymes. Consequently, only a few techniques used in tracer studies with radiolabeled proteins can be applied to circulating tissue enzymes and this may explain the lack of communication between the fields of plasma protein metabolism and quantitative clinical enzymology. In the present study a summary is given of the basic methods used in both fields, with emphasis on the equivalence of various models and formalisms used by different authors. It is shown that major limitations in the study of circulating tissue enzymes can be overcome if two different, but simultaneously released, en zymes can be measured. The resulting method will also be applied to plasma protein metabolism.
Historically, lack of specificity for cancer cells has been a major problem in cancer treatment; however, the development of monoclonal antibodies (mAbs), which combine high specificity with multiple mechanisms of action (MoAs), started a revolution in anti-cancer treatment options which continues to date. As of January 2013, 15 major antibody products were being marketed for cancer treatment in various countries around the globe, 10 of which are unmodified mAbs, which generally have multiple potential MoAs and may act via direct, Fab-domain-related effects or indirect, Fc-domain-related effects. Fc-domain-related effects consist of immune-mediated effector functions, which include complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and antibody-dependent cellular phagocytosis (ADCP). ADCC and ADCP depend on the engagement of Fcγ-receptors (FcγR) on immune effector cells by Fc-domains clustered due to antibody–antigen binding. Similarly, CDC depends on the engagement of proteins of the complement system by clustered antibody Fc domains. In this chapter, preclinical and clinical studies with approved anti-cancer mAbs are reviewed, with an emphasis on the role of FcγR-mediated effector functions. The importance of therapeutic antibody–FcγR interactions for human treatment can be deduced from correlations of clinical responses with FcγR polymorphisms, results supported by a wealth of preclinical and in vitro studies.
This book provides an overview of the risk components of CoCo bonds. CoCos are hybrid financial instruments that convert into equity or suffer a write-down of the face value upon the appearance of a trigger event. The loss-absorption mechanism is automatically enforced either via the breaching of a particular accounting ratio, typically in terms of the Common Equity Tier 1 (CET1) ratio, or via a regulatory trigger. CoCos are non-standardised instruments with different loss-absorption and trigger mechanisms. They might also contain additional features such as the cancellation of coupon payments. Different pricing models are discussed in detail. These models use market data such as share prices, CDS levels and implied volatility in order to calculate the theoretical price of a CoCo bond and its sensitivities, providing the investor with insides to hedge from adverse changes in the market conditions. The audience are professionals as well as academics who want to learn how to risk manage CoCo bonds using cutting edge techniques as well as all the risk involved in CoCo bonds.
Originally published in 1992 and now with an updated Preface this book analyses the development of innovations using a network perspective. The book offers practical guidelines with direct managerial relevance based on evidence collected from twenty-two case studies. First introducing theories of product development, adoption and diffusion, it then places them in the context of industrial networks, investigating such topics as user-involvement, interaction and market strategies. The book is essential reading for students of marketing, technology and strategy.
This is a Ph.D. dissertation. Because of the worldwide burden of bronchial asthma and the recent increase in the use of lung transplantation as a treatment for end-stage lung disease, the importance of chronic inflammatory airway diseases, such as asthma
The fourteen papers in this volume Studies in Dutch Phonology were collected by the editors in the course of 1977 and 1978, at the request of the editorial board of Dutch Studies. In their opinion the collection represents a fair cross-section of current research done in the field of phonology both inside and outside the Netherlands, and therefore con stitutes a very suitable starting point for the new series Dutch Studies of the Intemationale Vereniging voor Neerlandistiek. In the various contributions one will find treated several issues of current phonological interest, such as phonotactic constraints (by Brink), abstractness (by Goyvaerts, Robinson, Tiersma, Trommelen and Zonneveld), stress-assign ment and vowel-reduction (by Van MarIe and Predota), the interaction between phonology and morphology (by Kooij, De Rooij-Bronkhorst, and Schultink), rule ordering (Taeldeman), and lexical diffusion (Gerritsen and Jansen, and Zonneveld). These issues are discussed in relation to a number of well-known traditional topics of Dutch phonology, such as: affIxal stress-attraction; constraints on consonant-clusters; separable and inseparable verb-forms; stress and vowel reduction in derived vs. non derived, and 'native' vs. 'foreign' Dutch words; Auslautverhartung and assimilation of voice in obstruent-clusters; regularity and irregularity in open syllable lengthening, diminutive formation, plural formation, and the weakening of intervocalic d; and the properties and phonological represen tation of diphthongs. (Frans van Coetsem's paper "Loan Phonology: the Example of Dutch", originally intended as a contribution to this volume, but not completed as it went to the press, will appear elsewhere.
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.