Ozone, an important trace component, is critical to life on Earth and to atmospheric chemistry. The presence of ozone profoundly impacts the physical structure of the atmosphere and meteorology. Ozone is also an important photolytic source for HO radicals, the driving force for most of the chemistry that occurs in the lower atmosphere, is essential to shielding biota, and is the only molecule in the atmosphere that provides protection from UV radiation in the 250-300 nm region. However, recent concerns regarding environmental issues have inspired a need for a greater understanding of ozone, and the effects that it has on the Earth's atmosphere. The Mechanisms of Reactions Influencing Atmospheric Ozone provides an overview of the chemical processes associated with the formation and loss of ozone in the atmosphere, meeting the need for a greater body of knowledge regarding atmospheric chemistry. Renowned atmospheric researcher Jack Calvert and his coauthors discuss the various chemical and physical properties of the earth's atmosphere, the ways in which ozone is formed and destroyed, and the mechanisms of various ozone chemical reactions in the different spheres of the atmosphere. The volume is rich with valuable knowledge and useful descriptions, and will appeal to environmental scientists and engineers alike. A thorough analysis of the processes related to tropospheric ozone, The Mechanisms of Reactions Influencing Atmospheric Ozone is an essential resource for those hoping to combat the continuing and future environmental problems, particularly issues that require a deeper understanding of atmospheric chemistry.
With the impending demise of modernist planning, the footprints and corpses of failed modernist visions are littered everywhere. A vacuum of implementable urban theories has occurred at the time when unprecedented expansion and restructuring of cities in rapidly developing economies are taking place. In this collection of essays, William S W Lim zeroes in on the peculiarities and dynamics of present Asian urban and architectural conditions in order to challenge and transcend the socio-ecological forms and political influences generated by the current system of global capitalism. Part I of this book consists of the main essay, which attempts to establish baselines for an effective formulation of ethical urbanism in Asia, by clarifying issues that have previously been unquestioningly bound up with Western values and discourses. As an architect/urbanist, Lim lends a determinedly spatialist and environmental perspective to issues such as rights, ethics, happiness and social justice, while compelling his readers to rethink previously established notions about them. Part II of this book consists of three city studies on Hanoi, Shanghai and Singapore, completed in the last two years, which attempt to match LimOCOs theoretical formulation with actual conditions occurring in Asia today. Also included is OC Asian Architecture in the New MillenniumOCO, a fascinating discourse on contemporary design conducted from a postmodern perspective.
Today, more than 80% of the data transmitted over networks and archived on our computers, tablets, cell phones or clouds is multimedia data - images, videos, audio, 3D data. The applications of this data range from video games to healthcare, and include computer-aided design, video surveillance and biometrics. It is becoming increasingly urgent to secure this data, not only during transmission and archiving, but also during its retrieval and use. Indeed, in today’s "all-digital" world, it is becoming ever-easier to copy data, view it unrightfully, steal it or falsify it. Multimedia Security 1 analyzes the issues of the authentication of multimedia data, code and the embedding of hidden data, both from the point of view of defense and attack. Regarding the embedding of hidden data, it also covers invisibility, color, tracing and 3D data, as well as the detection of hidden messages in an image by steganalysis.
A wide variety of materials is being used in biomedical engineering for various functions. This includes a range of ceramics, polymers and metallic materials for implants and medical devices. A major question is how these materials will perform inside the body, which is very sensitive to alien materials. The material must not only survive to perform its intended function but also not initiate any damage to the surrounding tissue or induce a wider health problem. The service characteristics of implanted materials are of vital concern to health treatments that alleviate ageing.This book collates information and provides a concise text on the performance of different materials used in devices and implants. The knowledge presented is critical for a biomedical engineer, especially for the purpose of selecting the right materials. In addition, topics such as allergies and infection, tissue scaffolds, and drug delivery are reviewed.
After an overview of the fundamentals, limitations, and scope of reactive distillation, this book uses rigorous models for steady-state design and dynamic analysis of different types of reactive distillation columns and quantitatively compares the economics of reactive distillation columns with conventional multi-unit processes. It goes beyond traditional steady-state design that primarily considers the capital investment and energy costs when analyzing the control structure and the dynamic robustness of disturbances, and discusses how to maximize the economic and environmental benefits of reactive distillation technology.
Offering a thorough, accessible overview of the basic science and clinical data regarding the virus that causes COVID-19, Molecular Biology of SARS-CoV-2 is an excellent resource for researchers, clinical scientists, physicians, and students. This volume offers in-depth, extended content that originated with Drs. Roberto Patarca’s and William A. Haseltine’s chapter in The COVID-19 Textbook, edited by Dr. Haseltine and Dr. Patarca. The greatly expanded material in this text provides a much-needed primer in this complex area.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.
The pioneering physician scientist behind the New York Times bestseller Eat to Beat Disease reveals the science of eating your way to healthy weight loss. In his first groundbreaking book, Dr. William Li explored the world of food as medicine. By eating foods that you already enjoy, like tomatoes, blueberries, sourdough bread, and dark chocolate your body activates its five health defense systems to fight cancer, diabetes, cardiovascular, neurodegenerative autoimmune diseases, and other debilitating conditions. Now in Eat to Beat Your Diet, Dr. Li introduces the surprising new science of weight loss, revealing healthy body fat can help you lose weight; your metabolism at 60 can be the same as when you were 20; yo-yo dieting can be good for your health; 8-hour fasting windows can be as effective as 12-hour fasting windows; and losing just a little bit of weight can have big impacts on your health. Eat to Beat Your Diet shows readers how adding the right foods to your diet can heal your metabolism, reduce unhealthy body fat, and result in the kind of weight loss that can increase your lifespan and help you thrive. Foods like: Tomatoes Avocado Watermelon Carrots Blueberries Dark Chocolate Mushrooms Lentils Purple Maize Apple Cider Vinegar Turmeric Lobster Mussel Caviar Oysters Sea Bass Green Tea Soy Milk Coffee Pomegranate Juice Both informative and practical, Dr. Li offers a four-week meal plan for food lovers; easy food swaps and shopping tips; and more than a month of crowd-pleasing recipes.
Now in striking full color, this Seventh Edition of Koneman’s gold standard text presents all the principles and practices readers need for a solid grounding in all aspects of clinical microbiology—bacteriology, mycology, parasitology, and virology. Comprehensive, easy-to-understand, and filled with high quality images, the book covers cell and structure identification in more depth than any other book available. This fully updated Seventh Edition is enhanced by new pedagogy, new clinical scenarios, new photos and illustrations, and all-new instructor and student resources.
Offers a compendium of information on retrosynthesis and process chemistry, featuring innovative "reaction maps" showing synthetic routes of some widely used drugs This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the "best" processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of retrosynthesis and process chemistry—in order to show how retrosynthetic analysis assists in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process. The book also uses some key concepts used by process chemists to improve efficiency to indicate the best route to select. Each chapter in Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is dedicated to one drug, with each containing information on: worldwide sales and patent status of the Active Pharmaceutical Ingredient (API); structure analysis and general retrosynthetic strategy of the API; first reported synthesis; critical analysis of the processes which have been developed and comparison of the synthetic routes; lessons learned; reaction conditions for Schemes A to X; chemical "highlights" on key reactions used during the synthesis; and references. Drugs covered include: Gabapentin, Clopidogrel, Citalopram and Escitalopram, Sitagliptin, Ezetimibe, Montelukast, and Oseltamivir. Show how the retrosynthetic tool is used by the Pharmaceutical Industry Fills a gap for a book where retrosynthetic analysis is systematically applied to active pharmaceutical ingredients (APIs) Features analyses and methodologies that aid readers in uncovering practical synthetic routes to other drug substances, whether they be NCEs (New Chemical Entities) or generic APIs (Active Pharmaceutical Ingredients) Presents information from both the patent and academic literature for those who wish to use as a basis for further study and thought Features the use of "reaction maps" which display several synthetic processes in the same scheme, and which allow easy comparisons of different routes that give the same molecule or intermediate. A selection of these maps are available to download from: https://www.wiley.com/go/santos/retrosynthesis Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is an ideal book for researchers and advanced students in organic synthetic chemistry and process chemistry. It will also be of great benefit to practitioners in the pharmaceutical industry, particularly new starters, and those new to process chemistry.
Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text.
Psychiatry for the Boards, Second Edition is the most effective test preparation tool for standard clinical psychiatry exams, including the PRITE, the American Board of Psychiatry and Neurology written exam, recertification exams, and psychiatry questions on the USMLE Steps 2 and 3. The book presents high-yield information and mnemonics in an easy-to-read question-and-answer format. Appendices contain 100 sample Board-type questions and practical exam preparation tips. Completely updated, with nearly half the chapters rewritten, this edition is DSM-IV-TR compatible and includes new developments in psychopharmacology, neuroscience, and technology. Six new chapters cover human development; ECT, VNS, and DBS; seizure disorders; localized impairment—strokes, brain injuries, and brain tumors; peripheral nerve and muscle disorders; and cranial nerve symptoms and disorders.
The clinical approaches to the chronic degenerative diseases that drain our resources, and compromise our well-being, have become almost exclusively symptom-focused. The common wisdom is that they are idiopathic with final outcomes to be managed rather than prevented or cured. That they are potentially reversible rarely enters any discussion between doctor and patient. Reversibility of Chronic Disease and Hypersensitivity, Volume 5: Treatment Options of Chemical Sensitivity, the final volume of this set, offers a much different perspective on chronic degenerative disease; one that disputes the idiopathic label attached to most, as well as the usual fatalistic prognosis.
This is a thorough study of photosynthetic mechanisms from cells to leaves, crown, and canopy. The authors question whether photosynthetic adaptations take place primarily at the metabolic and biochemical level or through changes in structure and form, or both. The text goes on to analyze the relative importance of genes that control metabolic and light reactions, and the structure, arrangement, and orientation of photosynthesis.
The #1 guide to aerosol science and technology -now better than ever Since 1982, Aerosol Technology has been the text of choice among students and professionals who need to acquire a thorough working knowledge of modern aerosol theory and applications. Now revised to reflect the considerable advances that have been made over the past seventeen years across a broad spectrum of aerosol-related application areas - from occupational hygiene and biomedical technology to microelectronics and pollution control -this new edition includes: * A chapter on bioaerosols * New sections on resuspension, transport losses, respiratory deposition models, and fractal characterization of particles * Expanded coverage of atmospheric aerosols, including background aerosols and urban aerosols * A section on the impact of aerosols on global warming and ozone depletion. Aerosol Technology, Second Edition also features dozens of new, fully worked examples drawn from a wide range of industrial and research settings, plus new chapter-end practice problems to help readers master the material quickly.
With expert contributions from experienced educators, research scientists and clinicians, Foye’s Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This ‘gold standard’ text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.
Approximately 80% of the U.S. population now lives in urban metropolitan areas, and this number is expected to grow significantly in the coming years. At the same time, the built infrastructure sustaining these populations has become increasingly vulnerable to climate change. Stresses to existing systems, such as buildings, energy, transportation, water, and sanitation are growing. If the status quo continues, these systems will be unable to support a high quality of life for urban residents over the next decades, a vulnerability exacerbated by climate change impacts. Understanding this dilemma and identifying a path forward is particularly important as cities are becoming leading agents of climate action. Prepared as a follow-up to the Fourth National Climate Assessment (NCA), Climate Change and U.S. Cities documents the current understanding of existing and future climate risk for U.S. cities, urban systems, and the residents that depend on them. Beginning with an examination of the existing science since 2012, chapters develop connections between existing and emerging climate risk, adaptation planning, and the role of networks and organizations in facilitating climate action in cities. From studies revealing disaster vulnerability among low-income populations to the development of key indicators for tracking climate change, this is an essential, foundational analysis. Importantly, the assessment puts a critical emphasis on the cross-cutting factors of economics, equity, and governance. Urban stakeholders and decision makers will come away with a full picture of existing climate risks and a set of conclusions and recommendations for action. Many cities in the United States still have not yet planned for climate change and the costs of inaction are great. With bold analysis, Climate Change and U.S. Cities reveals the need for action and the tools that cities must harness to effect decisive, meaningful change.
This impressively comprehensive volume is a long-awaited and worthy successor to the now outdated 1978 classic, Evolution of African Mammals. A must-have reference work for everyone interested in mammalian evolution." David Pilbeam, Harvard University and the Peabody Museum of Archaeology and Ethnology --
Data Analysis Methods in Physical Oceanography, Fourth Edition provides a practical reference to established and modern data analysis techniques in earth and ocean sciences. In five sections, the book addresses data acquisition and recording, data processing and presentation, statistical methods and error handling, analysis of spatial data fields, and time series analysis methods. The updated edition includes new information on autonomous platforms and new analysis tools such as "deep learning and convolutional neural networks. A section on extreme value statistics has been added, and the section on wavelet analysis has been expanded. This book brings together relevant techniques and references recent papers where these techniques have been trialed. In addition, it presents valuable examples using physical oceanography data. For students, the sections on data acquisition are useful for a compilation of all the measurement methods. - Includes content co-authored by scientists from academia and industry, both of whom have more than 30 years of experience in oceanographic research and field work - Provides boxed worked examples that address typical data analysis problems, including examples with computer code (e.g., python code, MATLAB code) - Presents brief summaries at the end of the more difficult sections to help readers looking for foundational information
From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. This go-to medical reference book offers masterful guidance on the technical, scientific, and clinical challenges you face each day, in addition to providing the most up-to-date information available for effective board preparation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address the unique needs of pediatric patients with guidance from an entire section on pediatric anesthesia. View more than 1,500 full-color illustrations for enhanced visual clarity. Access step-by-step instructions for patient management, as well as an in-depth analysis of ancillary responsibilities and problems. Quickly reference important concepts with ‘Key Points’ boxes integrated into every chapter. Stay current on today's most recent anesthetic drugs and guidelines/protocols for anesthetic practice and patient safety, and access expanded coverage on new techniques such as TEE and other monitoring procedures. Take advantage of the unique, international perspectives of prominent anesthesiologists from all over the world, including the UK, Australia, India, Brazil, and Germany. Remain at the forefront of new developments in anesthesia with coverage of hot topics including Non-OR Anesthesia; Role of the Anesthesiologist in Disasters; Sleep Medicine in Anesthesia; Perioperative and Anesthesia-related Neurotoxicity; Anesthetic Implications of Complementary and Alternative Medicine; and Robotics. Study brand-new chapters on Perioperative Fluid Management; Extracorporeal Support Therapies; Anesthesia for Organ Donation/Procurement; and Malignant Hyperthermia and other Genetic Disorders.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
The COVID-19 Textbook: Science, Medicine, and Public Health explores every facet of SARS-COV-2, giving the reader an understanding of what is needed to control the spread of the virus, prevent and manage its pathological effects, as well as mitigate the impact of future pandemics. Each chapter is authored by leading global experts in the field and includes topics such as molecular biology, epidemiology, pathogenesis, immunology, diagnosis, and the latest prevention and treatment approaches. Edited by renowned educator and medical researcher Dr. William A. Haseltine, physician-researcher, and chronic fatigue syndrome expert Dr. Roberto Patarca, it includes detailed references in every chapter, allowing easy access to comprehensive primary data. • Offers a timely, reliable overview authored and edited by leading global experts in the multifaceted areas covered on SARS-CoV-2 and the COVID-19 pandemic. • Serves as an authoritative and comprehensive text to be utilized by physicians, medical professionals, researchers, students, public health professionals, and policymakers.
The world's most comprehensive, well documented, and well illustrated book on this subject. With extensive subject and geographic index. 231 photographs and illustrations - mostly color. Free of charge in digital PDF format.
In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The content is divided into sections of related disorders, including disorders of amino acid metabolism, lipid storage disorders, and mitochondrial diseases for ease of reference, with an introductory outline where appropriate summarizing the biochemical features and general management issues. Within the sections, each chapter deals with an individual disease, opening with a useful summary of major phenotypic expression including clear and helpful biochemical pathways, identifying for the reader exactly where the defect occurs. Throughout the book, plentiful photographs, often showing extremely rare disorders, are an invaluable aid to diagnosis. Key Features • Fully updated to incorporate all new developments in the field • Brand new chapters cover methylmalonic aciduria of ACSF3 deficiency, branched chain keto acid dehydrogenase deficiency, serine deficiencies, purine nucleoside phosphorylase deficiency, antiquitin deficiency, and others • Excellent and detailed clinical descriptions, with numerous valuable hints and suggestions for management • Helpful explanatory algorithms and decision trees, and high-quality illustrative material including biochemical pathways and an unrivaled photographic collection, which enhance clinical applicability The fourth edition of this highly regarded book, authored by two of the foremost authorities in pediatric metabolic medicine, continues to provide incomparable insight into the problems associated with metabolic diseases and remains invaluable to pediatricians, geneticists, and general clinicians worldwide.
The 1982 statistics on the use of family planning and infertility services presented in this report are preliminary results from Cycle III of the National Survey of Family Growth (NSFG), conducted by the National Center for Health Statistics. Data were collected through personal interviews with a multistage area probability sample of 7969 women aged 15-44. A detailed series of questions was asked to obtain relatively complete estimates of the extent and type of family planning services received. Statistics on family planning services are limited to women who were able to conceive 3 years before the interview date. Overall, 79% of currently mrried nonsterile women reported using some type of family planning service during the previous 3 years. There were no statistically significant differences between white (79%), black (75%) or Hispanic (77%) wives, or between the 2 income groups. The 1982 survey questions were more comprehensive than those of earlier cycles of the survey. The annual rate of visits for family planning services in 1982 was 1077 visits /1000 women. Teenagers had the highest annual visit rate (1581/1000) of any age group for all sources of family planning services combined. Visit rates declined sharply with age from 1447 at ages 15-24 to 479 at ages 35-44. Similar declines with age also were found in the visit rates for white and black women separately. Nevertheless, the annual visit rate for black women (1334/1000) was significantly higher than that for white women (1033). The highest overall visit rate was for black women 15-19 years of age (1867/1000). Nearly 2/3 of all family planning visits were to private medical sources. Teenagers of all races had higher family planning service visit rates to clinics than to private medical sources, as did black women age 15-24. White women age 20 and older had higher visit rates to private medical services than to clinics. Never married women had higher visit rates to clinics than currently or formerly married women. Data were also collected in 1982 on use of medical services for infertility by women who had difficulty in conceiving or carrying a pregnancy to term. About 1 million ever married women had 1 or more infertility visits in the 12 months before the interview. During the 3 years before interview, about 1.9 million women had infertility visits. For all ever married women, as well as for white and black women separately, infertility services were more likely to be secured from private medical sources than from clinics. The survey design, reliability of the estimates and the terms used are explained in the technical notes.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. You'll also have easy access to the complete contents and illustrations online at expertconsult.com. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease. Access the complete contents and illustrations online at expertconsult.com - fully searchable! Get the latest developments and a full understanding of the distinct physiology of the fetus and newborn so you can treat and manage sick newborns and preemies.
Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. - Uses individual drugs to explain molecular actions - Full color art program explains molecular and chemical concepts graphically - Logical structure reflecting the current state of pharmacology and translational research - Covers such intricacies as drug resistance and cell death - Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool
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