This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.
Will Wallace Harney (1832-1912) came to the Central Florida frontier in the years immediately following the Civil War, and established a homestead south of Orlando on the shores of Lake Conway. There he used the native timber to construct a magnificent home which he dubbed, Pine Castle. Within a few years, the name was being applied to the entire neighborhood. Beyond Pine Castle, Harney was better known for his skills as a writer, though he only published one thin volume of poetry during his lifetime. Most of his works appeared in regular submissions to popular magazines and newspapers. In the century since his death, his words have occasionally appeared in local publications. But no comprehensive collection of his writings had ever been published before this present anthology. The collected poetry, fiction, and letters of Will Wallace Harney reveal the important regional writer as a complex character, as inconsistent and difficult to define as the times in which he lived.
This revealing book synthesizes research from many fields to offer the first complete history of the roles played by weather and climate in American life from colonial times to the present. Author William B. Meyer characterizes weather events as neutral phenomena that are inherently neither hazards nor resources, but can become either depending on the activities with which they interact. Meyer documents the ways in which different kinds of weather throughout history have represented hazards and resources not only for such exposed outdoor pursuits as agriculture, warfare, transportation, construction, and recreation, but for other realms of life ranging from manufacturing to migration to human health. He points out that while the weather and climate by themselves have never determined the course of human events, their significance as been continuously altered for better and for worse by the evolution of American life.
By 1756 the wilderness war for control of North America that erupted two years earlier between France and England had expanded into a global struggle among all of Europe's Great Powers. Its land and sea battles raged across the North American continent, engulfed Europe and India, and stretched from the Atlantic to the Mediterranean, Indian, and Pacific waters. The new conflict, now commonly known as the Seven Years' War of 1756-1763, was a direct continuation of the last French and Indian War. This study explores the North American campaigns in relation to events elsewhere in the world, from the ministries of Whitehall and Versailles to the land and sea battles in Europe, Africa, South Asia, and the Caribbean. Few wars have had a more decisive effect on international relations and national development. The French and Indian War resulted in France's expulsion from almost all of the Western Hemisphere, except for some tiny islands in the Caribbean and St. Lawrence. Britain emerged as the world's dominant sea power and would remain so for two centuries. Finally, within a generation or two the vast debts incurred by Whitehall and Versailles in waging this war would help to stimulate revolutions in America and France that would forever change world history.
Presents the events of the Battle of Prairie Grove of 1862, which took place in Arkansas and ended the efforts of the Confederate Army to extend the Civil War conflict into the territory west of the MIssissippi River, discussing the generals, battle tactics, casualties, and aftermath.
First published in 1919, this fascinating volume provides an overview of the history of the Aetna Insurance Company, beginning with their very first president and policy. A history of the Aetna Insurance Company is arguably a history of modern insurance itself, making this volume a must-read for those with an interest in the topic. Contents include: "Thomas K. Brace, First and Third President", "Section of Original Petition for Aetna Charter", "Original Entry in First Record Book", "Seal of Aetna Insurance Company", "First Aetna Advertisement", "Henry L. Ellsworth, Second President", "Page from Correspondence Book No. I", "Aetna Policy No. I" ,"Aetna Office Building, 1837 to 1867", etc. William George Jordan (1864 - 1928) was an American lecturer, editor, and essayist. He is most famous for his self-help books, especially those on the subject of mental training and cognitive improvement. Other notable works by this author include: "Mental Training" (1894), "The Kingship of Self-Control" (1898), and "The Majesty of Calmness" (1900). Many vintage books such as this are becoming increasingly scarce and expensive. We are republishing this volume now in a modern, high-quality edition complete with a specially commissioned new biography of the author.
Throughout the 20th century, Brockport residents and visitors shared their experiences, sending postcards of the town to friends and family. These postcards present the important places and events that made visitors come back year after year and made residents proud to call the town home. This book complements the author's pictorial history Around Brockport in Arcadia Publishing's Images of America series. Along with Brockport, the towns of Sweden, Clarkson, and Hamlin are included in this extraordinary collection of postcards. The vintage postcards in this volume span a century of the area's history, presenting a portrait of the streets, buildings, events, and disasters that impacted the time and preserving the memories of the past for future generations.
At last, in this book, the great paradox of measurement is resolved. According to the authors' original -- and revealing -- research companies that manage by measurement outperform less disciplined competitors by an average three-year return on investment of 80 percent versus an average ROI of 45 percent. Yet few companies have put in place a disciplined approach for measuring the key nonfinancial, strategic performance areas that are so crucial to a firm's success. Bullseye! treats measurement as a key senior-management business issue. The authors explore the role of measurement in adding clarity and specificity to an organization's strategy, and in driving efforts to translate strategy into operational initiatives and business results. Organizational change and measurement experts William Schiemann and John Lingle have written the first book to provide a complete detailed blueprint for implementing a strategic measurement system. To resolve the measurement paradox, they have created as the centerpiece of Bullseye! a detailed case study that describes a four-phase process that will successfully transform any company into a measurement-managed organization. The four phases of this process are: defining a strategic business model, designing measures to support the model cascading the model and measures throughout the organization, and embedding the measures into the leadership processes of the organization. In eminently readable prose, the authors confront head-on the powerful forces that conspire to prevent a company from gaining the full value from its measurement system. In the process, Schiemann and Lingle have developed an integrative framework that covers all the major measurement areas: markets and customers, finance, people, operations, the environment, and suppliers. In fact, the authors go Beyond other published accounts of measurement systems by providing strategic tools to manage customer, community, environmental, and regulatory stakeholders along with suppliers, and adaptability -- the level at which a company learns and innovates. Focus and speed, they argue, are the essential competitive qualities. Following the guidelines recommended in this book, executives with responsibility for setting and implementing strategy should be able to make significant improvements in three months and major changes within a year. Bullseye! is must reading for all general managers at the corporate, division, and business-unit levels.
Drawing on groundbreaking and overwhelmingly extensive research into local court records, The Common Law in Colonial America proposes a "new beginning" in the study of colonial legal history, as it charts the course of the common law in Early America, to reveal how the models of law that emerged differed drastically from that of the English common law. In this first volume, Nelson explores how the law of the Chesapeake colonies--Virginia and Maryland--differed from the New England colonies--Massachusetts Bay, Connecticut, New Haven, Plymouth, and Rhode Island--and looks at the differences between the colonial legal systems within the two regions, from their initial settlement until approximately 1660.
A review of existing social science research concerning pretrial publicity that incorporates media theory and original field research and comes to the conclusion that fears of pretrial publicity are overstated.
Always study with the most up-to-date prep! Look for Regents Exams and Answers: U.S. History and Government, ISBN 9781506266657, on sale January 05, 2021. Publisher's Note: Products purchased from third-party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitles included with the product.
Enthält: The Siegel modular variety of degree two and level four / Ronnie Lee, Steven H. Weintraub. Cohomology of the Siegel modular group of degree two and level four / J. William Hoffman, Steven H. Weintraub.
In this boldly interpretive narrative, William McKee Evans tells the story of America's paradox of democracy entangled with a centuries-old system of racial oppression. This racial system of interacting practices and ideas first justified black slavery, then, after the Civil War, other forms of coerced black labor and, today, black poverty and unemployment. At three historical moments, a crisis in the larger society opened political space for idealists to challenge the racial system: during the American Revolution, then during the "irrepressible conflict" ending in the Civil War, and, finally, during the Cold War and the colonial liberation movements. Each challenge resulted in an historic advance. But none swept clean. Many African Americans remain segregated in jobless ghettoes with dilapidated schools and dismal prospects in an increasingly polarized class society. Evans sees a new crisis looming in a convergence of environmental disaster, endless wars, and economic collapse, which may again open space for a challenge to the racial system. African Americans, with their memory of their centuries-old struggle against oppressors, appear uniquely placed to play a central role.
Jazz on the River' describes how musical entrepreneurs gave the music of New Orleans to mainstream America in the 1920s, by quite literally sending their musicians upstream, aboard riverboats that plied the Mississippi waterways every summer.
A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed." —Amendment II, United States Constitution The Second Amendment is regularly invoked by opponents of gun control, but H. Richard Uviller and William G. Merkel argue the amendment has nothing to contribute to debates over private access to firearms. In The Militia and the Right to Arms, or, How the Second Amendment Fell Silent, Uviller and Merkel show how postratification history has sapped the Second Amendment of its meaning. Starting with a detailed examination of the political principles of the founders, the authors build the case that the amendment's second clause (declaring the right to bear arms) depends entirely on the premise set out in the amendment's first clause (stating that a well-regulated militia is necessary to the security of a free state). The authors demonstrate that the militia envisioned by the framers of the Bill of Rights in 1789 has long since disappeared from the American scene, leaving no lineal descendants. The constitutional right to bear arms, Uviller and Merkel conclude, has evaporated along with the universal militia of the eighteenth century. Using records from the founding era, Uviller and Merkel explain that the Second Amendment was motivated by a deep fear of standing armies. To guard against the debilitating effects of militarism, and against the ultimate danger of a would-be Caesar at the head of a great professional army, the founders sought to guarantee the existence of well-trained, self-armed, locally commanded citizen militia, in which service was compulsory. By its very existence, this militia would obviate the need for a large and dangerous regular army. But as Uviller and Merkel describe the gradual rise of the United States Army and the National Guard over the last two hundred years, they highlight the nation's abandonment of the militia ideal so dear to the framers. The authors discuss issues of constitutional interpretation in light of radically changed social circumstances and contrast their position with the arguments of a diverse group of constitutional scholars including Sanford Levinson, Carl Bogus, William Van Alstyne, and Akhil Reed Amar. Espousing a centrist position in the polarized arena of Second Amendment interpretation, this book will appeal to those wanting to know more about the amendment's relevance to the issue of gun control, as well as to those interested in the constitutional and political context of America's military history.
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