This work describes several statistical techniques for studying repeated measures data, presenting growth curve methods applicable to biomedical, social, animal, agricultural and business research. It details the multivariate development of growth science and repeated measures experiments, covering time-moving covariates, exchangable errors, bioassay results, missing data procedures and nonparametric and Bayesian methods.
In a field where even experts may find that years have elapsed since they last encountered a child with a given disorder, it is essential for the clinician to have a comprehensive source of practical and highly illustrated information covering the whole spectrum of metabolic disease to refer to. The content is divided into sections of related disorders, including disorders of amino acid metabolism, lipid storage disorders, and mitochondrial diseases for ease of reference, with an introductory outline where appropriate summarizing the biochemical features and general management issues. Within the sections, each chapter deals with an individual disease, opening with a useful summary of major phenotypic expression including clear and helpful biochemical pathways, identifying for the reader exactly where the defect occurs. Throughout the book, plentiful photographs, often showing extremely rare disorders, are an invaluable aid to diagnosis. Key Features • Fully updated to incorporate all new developments in the field • Brand new chapters cover methylmalonic aciduria of ACSF3 deficiency, branched chain keto acid dehydrogenase deficiency, serine deficiencies, purine nucleoside phosphorylase deficiency, antiquitin deficiency, and others • Excellent and detailed clinical descriptions, with numerous valuable hints and suggestions for management • Helpful explanatory algorithms and decision trees, and high-quality illustrative material including biochemical pathways and an unrivaled photographic collection, which enhance clinical applicability The fourth edition of this highly regarded book, authored by two of the foremost authorities in pediatric metabolic medicine, continues to provide incomparable insight into the problems associated with metabolic diseases and remains invaluable to pediatricians, geneticists, and general clinicians worldwide.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
This book describes methods for designing and analyzing experiments that are conducted using a computer code, a computer experiment, and, when possible, a physical experiment. Computer experiments continue to increase in popularity as surrogates for and adjuncts to physical experiments. Since the publication of the first edition, there have been many methodological advances and software developments to implement these new methodologies. The computer experiments literature has emphasized the construction of algorithms for various data analysis tasks (design construction, prediction, sensitivity analysis, calibration among others), and the development of web-based repositories of designs for immediate application. While it is written at a level that is accessible to readers with Masters-level training in Statistics, the book is written in sufficient detail to be useful for practitioners and researchers. New to this revised and expanded edition: • An expanded presentation of basic material on computer experiments and Gaussian processes with additional simulations and examples • A new comparison of plug-in prediction methodologies for real-valued simulator output • An enlarged discussion of space-filling designs including Latin Hypercube designs (LHDs), near-orthogonal designs, and nonrectangular regions • A chapter length description of process-based designs for optimization, to improve good overall fit, quantile estimation, and Pareto optimization • A new chapter describing graphical and numerical sensitivity analysis tools • Substantial new material on calibration-based prediction and inference for calibration parameters • Lists of software that can be used to fit models discussed in the book to aid practitioners
Established in 1896 with the coming of the Ottawa, Arnprior and Parry Sound Railway, Rock Lake Station was for over forty years a bustling centre for Algonquin park tourism and commerce. Unfortunately the demise of the railway in the late 1940's sealed its fate and today there are no signs of its existence, unless one knows where and how to look, . This book is the third in a series of narratives designed to bring to life the human history of Algonquin Park with specific focus on over 100 years of an active and vibrant Rock Lake and Whitefish Lake community.
Unter "bewehrtem Beton" versteht man eine Kombination von Beton mit anderen, verstärkenden Materialien (meist Stahl). Aus Stahlbetonplatten werden nicht nur Häuser gebaut, sondern auch Straßen und Mauern. Bauingenieure müssen die Merkmale und Einsatzfelder dieser Werkstoffe kennen und Belastungsgrenzen abschätzen. Dieses Buch, das einzige seiner Art, dient Praktikern und Studenten der Bautechnik als kompetenter Begleiter. (01/00)
Encapsulated cells offer enormous potential for the treatment of human disease. This work includes detailed descriptions of chemical properties of encapsulation materials, purification, biocompatibility issues and experimental protocols.
Forming connections between human performance and design, this new edition of Engineering Psychology and Human Performance examines human–machine interaction. The book is organized directly from a psychological perspective of human information processing, and chapters correspond to the flow of information as it is processed by a human being—from the senses, through the brain, to action—rather than from the perspective of system components or engineering design concepts. Upon completing this book, readers will be able to identify how human ability contributes to the design of technology; understand the connections within human information processing and human performance; challenge the way they think about technology’s influence on human performance; and show how theoretical advances have been, or might be, applied to improving human–machine interactions. This new edition includes the following key features: A new chapter on research methods Sections on interruption management and distracted driving as cogent examples of applications of engineering psychology theory to societal problems A greatly increased number of references to pandemics, technostress, and misinformation New applications Amplified emphasis on readability and commonsense examples Updated and new references throughout the text This book is ideal for psychology and engineering students, as well as practitioners in engineering psychology, human performance, and human factors. The text is also supplemented by online resources for students and instructors.
With expert contributions from experienced educators, research scientists and clinicians, Foye’s Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This ‘gold standard’ text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.
Nephrology and Fluid/Electrolyte Physiology, a volume in Dr. Polin’s Neonatology: Questions and Controversies Series, offers expert authority on the toughest neonatal nephrology and fluid/electrolyte challenges you face in your practice. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances. Reconsider how you handle difficult practice issues with coverage that addresses these topics head on and offers opinions from the leading experts in the field, supported by evidence whenever possible. Find information quickly and easily with a consistent chapter organization. Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care. Stay current in practice with coverage on lung fluid balance in developing lungs and its role in neonatal transition; acute problems of prematurity: balancing fluid volume and electrolyte replacement in very-low-birth-weight and extremely-low-birth-weight neonates; and much more.
Nephrology and Fluid/Electrolyte Physiology, a volume in Dr. Polin's Neonatology: Questions and Controversies Series, offers expert authority on the toughest neonatal nephrology and fluid/electrolyte challenges you face in your practice. This medical reference book will help you provide better evidence-based care and improve patient outcomes with research on the latest advances. Reconsider how you handle difficult practice issues with coverage that addresses these topics head on and offers opinions from the leading experts in the field, supported by evidence whenever possible. Find information quickly and easily with a consistent chapter organization. Get the most authoritative advice available from world-class neonatologists who have the inside track on new trends and developments in neonatal care. Purchase each volume individually, or get the entire 6-volume set, which includes online access that allows you to search across all titles! Stay current in practice with coverage on lung fluid balance in developing lungs and its role in neonatal transition; acute problems of prematurity: balancing fluid volume and electrolyte replacement in very-low-birth-weight and extremely-low-birth-weight neonates; and much more. Access the fully searchable text online at www.expertconsult.com.
Are you a practicing occupational hygienist wondering how to find a substitute organic solvent that is safer to use than the hazardous one your company is using? Chapter 6 is your resource. Are you a new hygienist looking for an alternative technology as a nonventilation substitute for an existing hazard? Chapter 8 is your resource. Are you looking for an overview of ventilation? Chapters 10 and 11 are your resource? Are you an industrial hygiene student wanting to learn about local exhaust ventilation? Chapters 13 through 16 are your resource. Are you needing to learn about personal protective equipment and respirators? Chapters 21 and 22 are your resources. This new edition brings all of these topics and more right up-to-date with new material in each chapter, including new governmental regulations. While many of the controls of airborne hazards have their origins in engineering, this author has been diligent in explaining concepts, writing equations in understandable terms, and covering the topics of non-ventilation controls, both local exhaust and general ventilation, and receiver controls at the level needed by most IHs without getting too advanced. Taken as a whole, this book provides a unique, comprehensive tool to learn the challenging yet rewarding role that industrial hygiene can play in controlling airborne chemical hazards at work. Most chapters contain a set of practice problems with the solutions available to instructors. Features Written for the novice industrial hygienist but useful to prepare for ABIH certification Explains engineering concepts but requires no prior engineering background Includes specific learning goals that differentiate the depth of learning appropriate to each topic within the fuller information and explanations provided for each chapter Contains updated governmental regulations and abundant references Presents a consistent teaching philosophy and approach throughout the book Deals with both ventilation and non-ventilation controls
A sensitive, authoritative, and up-to-date guide to common gynecological problems and procedures answers questions about the diagnosis and treatment of fibroids, ovarian cysts, endometriosis, pelvic pain, and related problems.
The single most important book on wetlands, newly expanded and updated Wetlands is the definitive guide to this fragile ecosystem, providing the most comprehensive coverage and in-depth information available in print. Recently updated and expanded, this latest edition contains brand new information on Wetland Ecosystem Services and an updated discussion on Wetland, Carbon, and Climate Change and Wetland Creation and Restoration. Due to popular demand, the authors have brought back five streamlined chapters on wetland ecosystems that had been removed from previous editions, and provided more robust ancillary materials including an online color photo gallery, PowerPoint slides, and several video case studies. As nature's kidneys, wetland ecosystems help the environment process toxins and excess fertilizers and maintain the relative health of our aquatic ecosystems. As the understanding of their importance grows, their management and ecology have gained increased attention and have become an area of professional specialization over the past two decades. This book gives readers a solid understanding of wetlands, how they work, what they do, and why the Earth can't live without them. Understand wetlands' role in the ecosystem, from local to global scales Appreciate the fact that wetlands may be the most logical and economical way to sequester carbon from the atmosphere Discover the unique characteristics that make wetlands critically important for improving water quality, reducing storm and flood damage, and providing habitat to support biodiversity Learn how wetlands are being managed or destroyed around the globe but also how we can create and restore them Examine the ways in which climate change is affecting wetland ecosystems and wetland ecosystems affect climate change Wetlands are crucial to the health of the planet, and we've only begun to realize the magnitude of the damage that has already been done as we scramble to save them. A generation of ecologists, ecological engineers, land use planners, and water resource managers worldwide owe their knowledge of the wetlands to this book – for the next generation to follow in their footsteps, Wetlands 5th edition is the quintessential guide to these critical systems.
The Transportation Experience explores the historical evolution of transportation modes and technologies. The book traces how systems are innovated, planned and adapted, deployed and expanded, and reach maturity, where they may either be maintained in a polished obsolesce often propped up by subsidies, be displaced by competitors, or be reorganized and renewed. An array of examples supports the idea that modern policies are built from past experiences. William Garrison and David Levinson assert that the planning (and control) of nonlinear, unstable processes is today's central transportation problem, and that this is universal and true of all modes. Modes are similar, in that they all have a triad structure of network, vehicles, and operations; but this framework counters conventional wisdom. Most think of each mode as having a unique history and status, and each is regarded as the private playground of experts and agencies holding unique knowledge, operating in isolated silos. However, this book argues that while modes have an appearance of uniqueness, the same patterns repeat: systems policies, structures, and behaviors are a generic design on varying modal cloth. In the end, the illusion of uniqueness proves to be myopic. While it is true that knowledge has accumulated from past experiences, the heavy hand of these experiences places boundaries on current knowledge; especially on the ways professionals define problems and think about processes. The Transportation Experience provides perspective for the collections of models and techniques that are the essence of transportation science, and also expands the boundaries of current knowledge of the field.
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