William R Strohl's Books

Therapeutic Antibody Engineering

Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

By: William R Strohl,Lila M Strohl

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Therapeutic Antibody Engineering

Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

By: William R Strohl,Lila M Strohl

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. - Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships - Integration of knowledge across all areas of antibody engineering, development, and marketing - Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

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697

Publisher

Elsevier

Published Date

ISBN 10

1908818093

ISBN 13

9781908818096

Introduction to Biological and Small Molecule Drug Research and Development

Chapter 4. Protein therapeutics (introduction to biopharmaceuticals)

By: Jill M. Carton,William R. Strohl

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Introduction to Biological and Small Molecule Drug Research and Development

Chapter 4. Protein therapeutics (introduction to biopharmaceuticals)

By: Jill M. Carton,William R. Strohl

Throughout human history, the morbidity and mortality associated with human disease has driven medical science into an ever-expanding quest for treatment and cure. Over the past century, a therapeutic approach complementing chemical drugs has been developing which uses proteins and peptides in the treatment of disease. Many innovative protein therapeutic platforms are currently being employed and continue to be developed to attain cures in areas of unmet medical need; these include direct copies of natural protein structure and function as well as proteins with completely novel functionality. Today, protein therapeutics represents the fastest growing sector in the pharmaceutical industry and comprises 16% of prescription drug sales in 2011.

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Elsevier Inc. Chapters

Published Date

ISBN 10

0128061944

ISBN 13

9780128061947

Therapeutic Antibody Engineering

Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

By: William R Strohl,Lila M Strohl

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Therapeutic Antibody Engineering

Current and Future Advances Driving the Strongest Growth Area in the Pharmaceutical Industry

By: William R Strohl,Lila M Strohl

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697

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Elsevier

Published Date

ISBN 10

1908818093

ISBN 13

9781908818096

A COPD Primer

By: Ralph Panos,William Eschenbacher

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A COPD Primer

By: Ralph Panos,William Eschenbacher

In 2012 we received a grant from the Veterans Health Administration Office of Specialty Care entitled, “Patient-Centered Model for the Management of Chronic Obstructive Pulmonary Disease.” The grant’s goals were to enhance the recognition and diagnosis of COPD and implement a Patient-Centered Model for the Management of COPD. As the work on that proposal progressed, we realized that providers did not have an up-to-date, comprehensive, easily read, “how to” manual for the management of COPD despite all the advances in COPD care that have occurred over the past 5 years. Consensus documents such as the VA-DOD Guidelines were abbreviated summaries that were rarely used. From those discussions, the concept for this volume, a COPD Primer, developed. The goal was to develop a practical book that concisely presented COPD to providers with sufficient background and explanation of the physiologic and scientific rationale for various management strategies without becoming an esoteric academic work. We hope that this COPD Primer has achieved that goal and will be a useful, practical text for practitioners and medical trainees alike. The COPD Primer begins with an examination of what COPD is; it is really a syndrome, a constellation of historical features and clinical, physiologic, and radiographic findings. However, those elements come together in many different ways to create multiple different COPD phenotypes that are only now being recognized and used to define specific management strategies. COPD research has progressed beyond the simple classification of “blue bloaters” and “pink puffers.” Next, the epidemiology and economic consequences of COPD are reviewed. Bill Eschenbacher presents an approach to the patient with respiratory symptoms with detailed discussions of pulmonary function testing and how airflow limitation/obstruction is identified by spirometry and the use of lung imaging to identify individuals with COPD. Michael Borchers and Gregory Motz summarize current evidence implicating genetics, proteolytic imbalance, oxidative stress, inflammation, occupational and environmental exposures, and innate and adaptive immune function in the pathogenesis of COPD and the implication of these findings to future treatments. The single most important intervention in the prevention and treatment of COPD is smoking cessation. Shari Altum, Katherine Butler, and Rachel Juran present a practical approach to smoking cessation utilizing motivational interviewing in combination with pharmacologic interventions. Then, they expand upon these concepts to provide practitioners with convenient, realistic suggestions to encourage patient self-management in all aspects of COPD care and overall health. Ahsan Zafar reviews the natural history, recently described COPD phenotypes, and gender differences that clearly illustrate the broad spectrum of disease that comprises the term, COPD. The cover illustration highlights Dr. Zafar’s creative and artistic talents. The extensive nonpulmonary aspects of COPD are reviewed by Ralph Panos in an examination of COPD’s multi-organ manifestations. Next, the effect of COPD on sleep and the overlap syndrome, the concurrence of COPD and obstructive sleep apnea, and its consequences are presented. Jean Elwing examines the effect of COPD on the pulmonary vasculature with a detailed discussion of the evaluation and management of pulmonary hypertension associated with COPD. COPD’s effects on psychosocial functioning and familial interactions are presented by Mary Panos and Ralph Panos. The focus of the Primer then shifts from manifestations to treatment with a discussion of stable COPD management. With the current plethora of devices for delivering respiratory medications, it is difficult for both patients and providers to sustain knowledge of their proper use. Aaron Mulhall presents a practical guide to correct inhaler use that reviews all the current devices. Folarin Sogbetun then reviews the management of outpatient COPD exacerbations and Nishant Gupta discusses the approach to the patient hospitalized with COPD. Because patients with COPD often see multiple subspecialty physicians in addition to their primary care providers, interdisciplinary communication and coordination of care is essential for their management; Sara Krzywkowski-Mohn reviews the interactions between primary and specialty care for the patient with COPD with suggestions for improved communication and care coordination. Finally, advance care planning including palliative care and hospice is reviewed with a discussion of how end stage COPD affects not only the patient but also their family and social network. This COPD Primer incorporates the knowledge that we have learned over the past several years during the development and implementation of a patient-centered model for the management of COPD. It was written with the explicit goal of assisting both the practicing provider and medical trainee in the care of patients with COPD.

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415

Publisher

Walter de Gruyter GmbH & Co KG

Published Date

ISBN 10

311046800X

ISBN 13

9783110468007

Principles and Practice of Sleep Medicine E-Book

By: Meir H. Kryger,Thomas Roth,William C. Dement

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Principles and Practice of Sleep Medicine E-Book

By: Meir H. Kryger,Thomas Roth,William C. Dement

For nearly 30 years, Dr. Meir Kryger’s must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. Evidence-based content helps you make the most well-informed clinical decisions. An ideal resource for preparing for the sleep medicine fellowship examination. New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women’s health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date. Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders.

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2542

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323377521

ISBN 13

9780323377522

Financing American Higher Education in the Era of Globalization

By: William Zumeta,David W. Breneman,Patrick M. Callan,Joni E. Finney

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Financing American Higher Education in the Era of Globalization

By: William Zumeta,David W. Breneman,Patrick M. Callan,Joni E. Finney

This ambitious book grows out of the realization that a convergence of economic, demographic, and political forces in the early twenty-first century requires a fundamental reexamination of the financing of American higher education. The authors identify and address basic issues and trends that cut across the sectors of higher education, focusing on such questions as how much higher education the country needs for individual opportunity and for economic viability in the future; how responsibility for paying for it is currently allocated; and how financing higher education should be addressed in the future.

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372

Publisher

Harvard Education Press

Published Date

ISBN 10

1612502539

ISBN 13

9781612502533

The Fifth Wave

The Evolution of American Higher Education

By: Michael M. Crow,William B. Dabars

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The Fifth Wave

The Evolution of American Higher Education

By: Michael M. Crow,William B. Dabars

Out of the crises of American higher education emerges a new class of large-scale public universities designed to accelerate social change through broad access to world-class knowledge production and cutting-edge technological innovation. America's research universities lead the world in discovery, creativity, and innovation—but are captive to a set of design constraints that no longer aligns with the changing needs of society. Their commitment to discovery and innovation, which is carried out largely in isolation from the socioeconomic challenges faced by most Americans, threatens to impede the capacity of these institutions to contribute decisively and consistently to the collective good. The global preeminence of our leading institutions, moreover, does not correlate with overall excellence in American higher education. Sadly, admissions practices that flatly exclude the majority of academically qualified applicants are now the norm in our leading universities, both public and private. In The Fifth Wave, Michael M. Crow and William B. Dabars argue that colleges and universities need to be comprehensively redesigned in order to educate millions more qualified students while leveraging the complementarities between discovery and accessibility. Building on the themes of their prior collaboration, Designing the New American University, this book examines the historical development of American higher education—the first four waves—and describes the emerging standard of institutions that will transform the field. What must emerge in this Fifth Wave of universities, Crow and Dabars posit, are institutions that are responsive to the needs of students, focused on access, embedded in their regions, and committed to solving global problems. The Fifth Wave in American higher education, Crow and Dabars write, comprises an emerging league of colleges and universities that aspires to accelerate positive social outcomes through the seamless integration of world-class knowledge production with cutting-edge technological innovation. This set of institutions is dedicated to the advancement of accessibility to the broadest possible demographic that is representative of the socioeconomic and intellectual diversity of our nation. Recognizing the fact that both cooperation and competition between universities is essential if higher education hopes to truly serve the needs of the nation, Fifth Wave schools like Arizona State University are already beginning to spearhead a network spanning academia, business and industry, government agencies and laboratories, and civil society organizations. Drawing from a variety of disciplines, including design, economics, public policy, organizational theory, science and technology studies, sociology, and even cognitive psychology and epistemology, The Fifth Wave is a must-read for anyone concerned with the future of higher education in our society.

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497

Publisher

JHU Press

Published Date

ISBN 10

1421438038

ISBN 13

9781421438030

The Real College Debt Crisis

How Student Borrowing Threatens Financial Well-Being and Erodes the American Dream

By: William Elliott III,Melinda K. Lewis

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The Real College Debt Crisis

How Student Borrowing Threatens Financial Well-Being and Erodes the American Dream

By: William Elliott III,Melinda K. Lewis

Is it still worth it for low-income students to attend college, given the debt incurred? This book provides a new framework for evaluating the financial aid system in America, positing that aid must not only allow access to higher education, but also help students succeed in college and facilitate their financial health post-college. Higher education plays a critical role in the economy and society of the United States, creating a ladder of economic opportunity for American children, especially for those in poverty. Unfortunately, higher education today increasingly reinforces patterns of relative privilege, particularly as students without the benefit of affluent parents rely more and more on student loans to finance college access. This book presents penetrating new information about the fiscal realities of the current debt-based college loan system and raises tough questions about the extent to which student loans can be a viable way to facilitate equitable access to higher education. The book opens with relevant parts of the life stories of two students—one who grew up poor and had to take on high amounts of student debt, and another whose family could offer financial help at critical times. These real-life examples provide invaluable insight into the student debt problem and help make the complex data more understandable. A wide range of readers—from scholars of poverty, social policy, and educational equality to policymakers to practitioners in the fields of student financial aid and financial planning—will find the information in this text invaluable.

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266

Publisher

Bloomsbury Publishing USA

Published Date

ISBN 10

1440836477

ISBN 13

9781440836473

Respiratory Care

Principles and Practice

By: Dean R. Hess,Neil R. MacIntyre,Shelley C. Mishoe,William F. Galvin

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Respiratory Care

Principles and Practice

By: Dean R. Hess,Neil R. MacIntyre,Shelley C. Mishoe,William F. Galvin

A new edition of the classic text, Respiratory Care: Principles and Practice, Second Edition is a truly authoritative text for respiratory care students who desire a complete and up to date exploration of the technical and professional aspects of respiratory care. With foundations in evidence-based practice, this essential text reviews respiratory assessment, respiratory therapeutics, respiratory diseases, basic sciences and their application to respiratory care, the respiratory care profession, and much more. Important Notice: The digital edition of this book is missing some of the images or content found in the physical edition.

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Page Count

1396

Publisher

Jones & Bartlett Publishers

Published Date

ISBN 10

1449656285

ISBN 13

9781449656287

Companion to Clinical Neurology

By: William Pryse-Phillips

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Companion to Clinical Neurology

By: William Pryse-Phillips

Depicts or explains neurology's bygone leaders as well as its symptoms, signs, syndromes, diseases, eponyms, operative procedures, and diagnostic tests."--Foreword.

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1127

Publisher

Oxford : Oxford University Press

Published Date

ISBN 10

0195159381

ISBN 13

9780195159387

Miller's Anesthesia E-Book

By: Ronald D. Miller,Lars I. Eriksson,Lee A Fleisher,Jeanine P. Wiener-Kronish,Neal H Cohen,William L. Young

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Miller's Anesthesia E-Book

By: Ronald D. Miller,Lars I. Eriksson,Lee A Fleisher,Jeanine P. Wiener-Kronish,Neal H Cohen,William L. Young

From fundamental principles to advanced subspecialty procedures, Miller’s Anesthesia covers the full scope of contemporary anesthesia practice. This go-to medical reference book offers masterful guidance on the technical, scientific, and clinical challenges you face each day, in addition to providing the most up-to-date information available for effective board preparation. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Address the unique needs of pediatric patients with guidance from an entire section on pediatric anesthesia. View more than 1,500 full-color illustrations for enhanced visual clarity. Access step-by-step instructions for patient management, as well as an in-depth analysis of ancillary responsibilities and problems. Quickly reference important concepts with ‘Key Points’ boxes integrated into every chapter. Stay current on today's most recent anesthetic drugs and guidelines/protocols for anesthetic practice and patient safety, and access expanded coverage on new techniques such as TEE and other monitoring procedures. Take advantage of the unique, international perspectives of prominent anesthesiologists from all over the world, including the UK, Australia, India, Brazil, and Germany. Remain at the forefront of new developments in anesthesia with coverage of hot topics including Non-OR Anesthesia; Role of the Anesthesiologist in Disasters; Sleep Medicine in Anesthesia; Perioperative and Anesthesia-related Neurotoxicity; Anesthetic Implications of Complementary and Alternative Medicine; and Robotics. Study brand-new chapters on Perioperative Fluid Management; Extracorporeal Support Therapies; Anesthesia for Organ Donation/Procurement; and Malignant Hyperthermia and other Genetic Disorders.

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4094

Publisher

Elsevier Health Sciences

Published Date

ISBN 10

0323280110

ISBN 13

9780323280112

Student Debt

A Reference Handbook

By: William Elliott III,Melinda K. Lewis

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Student Debt

A Reference Handbook

By: William Elliott III,Melinda K. Lewis

Offering answers to essential questions about student debt and many connected issues, this book examines student debt in the United States at every stage of the process—from the banks that issue the loans to the colleges and universities that collect the payments. Student lending in the United States is one of the most controversial issues in contemporary American discourse. Are these loans the only option for Americans who want to attend college and university in order to attain the best careers and have a productive, enjoyable life? Should the predatory lending practices of for-profit colleges and universities be stopped? How can limits be imposed on student lending amounts without preventing students from getting the education they need to succeed? The book explains why so many students are borrowing large amounts of money to attend college; considers whether the cost of higher education is simply too high, and if there should be a cap on how much money students can borrow; explains what is contributing to the rising rate of borrowers defaulting on their loans; and predicts whether the so-called student loan bubble is in danger of popping. The Data and Documents chapter analyzes data gathered from discussions about student debt. This information enables readers to better understand who is borrowing student loans, what the money from the student loans is going toward, what individuals have the authority to decide who qualifies for these loans, and what is being done to curb wasteful student spending.

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324

Publisher

Bloomsbury Publishing USA

Published Date

ISBN 10

1440844887

ISBN 13

9781440844881

History of Soybeans and the Great Agricultural Revolution (1874-2021)

Extensively Annotated Bibliography and Sourcebook

By: William Shurtleff; Akiko Aoyagi

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History of Soybeans and the Great Agricultural Revolution (1874-2021)

Extensively Annotated Bibliography and Sourcebook

By: William Shurtleff; Akiko Aoyagi

The world's most comprehensive, well document, and well illustrated book on this subject. With extensive subject and geographical index. 136 photographs and illustrations - many in color. Free of charge in digital PDF format.

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843

Publisher

Soyinfo Center

Published Date

ISBN 10

194843640X

ISBN 13

9781948436403

Textbook of Clinical Pediatrics

By: H. A. Harfi,H. Nazer,William Oh,F. B. Stapleton,R. J. Whitley

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Textbook of Clinical Pediatrics

By: H. A. Harfi,H. Nazer,William Oh,F. B. Stapleton,R. J. Whitley

The new edition of this classic reference offers a problem-based approach to pediatric diseases. It encompasses almost all pediatric subspecialties and covers every pediatric disease and organ system. It includes case studies and over 750 lavish illustrations.

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4213

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3642022022

ISBN 13

9783642022029

Designing the New American University

By: Michael M. Crow,William B. Dabars

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Designing the New American University

By: Michael M. Crow,William B. Dabars

Intro -- Contents -- Preface, by Michael M. Crow -- Acknowledgments -- Introduction: Solving for X with U -- 1 American Research Universities at a Fork in the Road -- 2 The Gold Standard in American Higher Education -- 3 The Varieties of Academic Tradition -- 4 Discovery, Creativity, and Innovation -- 5 Designing Knowledge Enterprises -- 6 A Pragmatic Approach to Innovation and Sustainability -- 7 Designing a New American University at the Frontier -- Conclusion: Toward More New American Universities -- Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- R -- S -- T -- U -- W -- Z.

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361

Publisher

JHU Press

Published Date

ISBN 10

1421417235

ISBN 13

9781421417233

Performance Consulting

Applying Performance Improvement in Human Resource Development

By: William J. Rothwell

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Performance Consulting

Applying Performance Improvement in Human Resource Development

By: William J. Rothwell

Performance Consulting If organizations are to be successful they must improve individual and organizational performance in order to establish and maintain a high-performance workplace, develop intellectual capital, promote productivity, and ultimately enhance profitability. Performance Consulting reveals how to distinguish between the signs and symptoms of productivity problems from the underlying root causes and find the most ethical and cost-effective solutions to solve those problems. The book is written for performance consultants, HR professionals, and any leader who want to fulfill the role of a performance consultant in order to develop more productive workers and create a globally-competitive organization. Filled with illustrative examples from giants in the field of human performance technology, the book describes the skills needed in order to become an effective performance consultant. Step by step the author clearly shows how to uncover and deal with challenges and opportunities to improve human performance of organizations by analyzing their present and envisioning their future. The book offers vital information for examining an organization's present conditions that are associated with data collection and analysis methods. It also describes how to foresee future conditions of an organization associated with relevant sources in order to determine their future course. Performance Consulting includes guidelines for implementing performance improvement solutions, which are often identified as performance improvement interventions. The book explains which approaches can offer the solutions that are likely to be most cost-effective, timely, ethical, and socially-responsible. No matter what size your organization or your current job responsibilities, Performance Consulting offers the strategies and information needed to become a dynamic performance consultant.

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528

Publisher

John Wiley & Sons

Published Date

ISBN 10

1118416279

ISBN 13

9781118416273

Book's by William R Strohl

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering

A COPD Primer

A COPD Primer

Principles and Practice of Sleep Medicine E-Book

Principles and Practice of Sleep Medicine E-Book

Financing American Higher Education in the Era of Globalization

Financing American Higher Education in the Era of Globalization

The Fifth Wave

The Fifth Wave

The Real College Debt Crisis

The Real College Debt Crisis

Respiratory Care

Respiratory Care

Companion to Clinical Neurology

Companion to Clinical Neurology

Miller's Anesthesia E-Book

Miller's Anesthesia E-Book

Student Debt

Student Debt

History of Soybeans and the Great Agricultural Revolution (1874-2021)

History of Soybeans and the Great Agricultural Revolution (1874-2021)

Textbook of Clinical Pediatrics

Textbook of Clinical Pediatrics

Designing the New American University

Designing the New American University

Performance Consulting

Performance Consulting

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