The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
In 1868, Dykesboro was incorporated as Cochran. The Macon and Brunswick Railroad enabled the community to ship cotton and corn and receive needed goods. As the town began to grow, education was always promoted by the churches. Ebenezer Academy, founded in 1884, became Middle Georgia College. In 1912, Bleckley County was created, and the county courthouse began operation on January 1, 1914. The local economy was good, and World War I brought a period of prosperity due to the need for food and fiber. In the 1920s, the boll weevil devastated the agricultural cotton economy and the Great Depression brought loss of economic wealth and financial hardships that were not relieved until after World War II .
Did You Know? This book is available as a Wiley E-Text. The Wiley E-Text is a complete digital version of the text that makes time spent studying more efficient. Course materials can be accessed on a desktop, laptop, or mobile device—so that learning can take place anytime, anywhere. A more affordable alternative to traditional print, the Wiley E-Text creates a flexible user experience: Access on-the-go Search across content Highlight and take notes Save money! The Wiley E-Text can be purchased in the following ways: Check with your bookstore for available e-textbook options Wiley E-Text: powered by VitalSource ISBN: 978-1-118-83353-7 Directly from: www.wiley.com/wiley-blackwell
The relentless loss of biodiversity is among the greatest problems facing the world today. The third edition of this established textbook provides an updated and comprehensive overview of the essential background, concepts, and tools required to understand how genetics can be used to conservespecies, reduce threat of extinction, and manage species of ecological or commercial importance. This edition is thoroughly revised to reflect the major contribution of genomics to conservation of populations and species. It includes two new chapters: "Genetic Monitoring" and a final "ConservationGenetics in Practice" chapter that addresses the role of science and policy in conservation genetics.New genomic techniques and statistical analyses are crucial tools for the conservation geneticist. This accessible and authoritative textbook provides an essential toolkit grounded in population genetics theory, coupled with basic and applied research examples from plants, animals, and microbes. Thebook examines genetic and phenotypic variation in natural populations, the principles and mechanisms of evolutionary change, evolutionary response to anthropogenic change, and applications in conservation and management.Conservation and the Genomics of Populations helps demystify genetics and genomics for conservation practitioners and early career scientists, so that population genetic theory and new genomic data can help raise the bar in conserving biodiversity in the most critical 20 year period in the historyof life on Earth. It is aimed at a global market of applied population geneticists, conservation practitioners, and natural resource managers working for wildlife and habitat management agencies. It will be of particular relevance and use to upper undergraduate and graduate students taking coursesin conservation biology, conservation genetics, and wildlife management.
Although Franklin Roosevelt's New Deal is remembered in large part because of the aid and assistance it brought to millions of unemployed and indigent Americans, surprisingly little has been written about federal relief for unemployment. The great experiment of the Federal Emergency Relief Act had implications that went beyond its immediate purpose: it challenged directly the deep-seated conviction that the relief of poverty was a local responsibility, and in doing so highlighted the deficiencies of local self-government. In reviewing the experiment of the F.E.R.A. and the New Deal, Professor Brock's book raises important questions about American attitudes toward welfare, local government, and national responsibility.
William Kauffman Scarborough has produced a work of incomparable scope and depth, offering the challenge to see afresh one of the most powerful groups in American history—the wealthiest southern planters who owned 250 or more slaves in the census years of 1850 and 1860. The identification and tabulation in every slaveholding state of these lords of economic, social, and political influence reveals a highly learned class of men who set the tone for southern society while also involving themselves in the wider world of capitalism. Scarborough examines the demographics of elite families, the educational philosophy and religiosity of the nabobs, gender relations in the Big House, slave management methods, responses to secession, and adjustment to the travails of Reconstruction and an alien postwar world.
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