Recent advances in next-generation sequencing have enabled high-throughput determination of biological sequences in microbial communities, also known as microbiomes. The large volume of data now presents the challenge of how to extract knowledge—recognize patterns, find similarities, and find relationships—from complex mixtures of nucleic acid sequences currently being examined. In this chapter we review basic concepts as well as state-of-the-art techniques to analyze hundreds of samples which each contain millions of DNA and RNA sequences. We describe the general character of sequence data and describe some of the processing steps that prepare raw sequence data for inference. We then describe the process of extracting features from the data, assigning taxonomic and gene labels to the sequences. Then we review methods for cross-sample comparisons: (1) using similarity measures and ordination techniques to visualize and measure differences between samples and (2) feature selection and classification to select the most relevant features for discriminating between samples. Finally, in conclusion, we outline some open research problems and challenges left for future research.
Highly readable, well-illustrated, and easy to understand, Gabbe's Obstetrics: Normal and Problem Pregnancies is an ideal day-to-day reference or study tool for residents and clinicians. This 8th Edition of this bestselling text offers fast access to evidence-based, comprehensive information, now fully revised with substantial content updates, new and improved illustrations, and a new, international editorial team that continues the tradition of excellence established by Dr. Steven Gabbe. - Puts the latest knowledge in this complex specialty at your fingertips, allowing you to quickly access the information you need to treat patients, participate knowledgably on rounds, and perform well on exams. - Contains at-a-glance features such as key points boxes, bolded text, chapter summaries and conclusions, key abbreviations boxes, and quick-reference tables, management and treatment algorithms, and bulleted lists throughout. - Features detailed illustrations from cover to cover—many new and improved—including more than 100 ultrasound images that provide an important resource for normal and abnormal fetal anatomy. - Covers key topics such as prevention of maternal mortality, diabetes in pregnancy, obesity in pregnancy, vaginal birth after cesarean section, and antepartum fetal evaluation. - Provides access to 11 videos that enhance learning in areas such as cesarean delivery and operative vaginal delivery. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices
More than half the numbers of children with epilepsy have interrelated language, learning and/or behavior complications. By adulthood, these problems can interfere with socialization and employment. The seizures may be controlled but the developmental distortions can continue to present problems for health and education systems and carers. In this comprehensive and fully referenced book, William Svoboda distils a lifetime of clinical experience with childhood epilepsy into three areas which address each of the main areas of difficulty. In each he looks at why the problems arise and assesses diagnostic and remediative approaches. The focus is on the whole care of the child rather than on diagnosis, classification and medication alone. Clinicians, mental health practitioners, educators and speech–language pathologists will find this book invaluable.
After 30 years, Obstetrics: Normal and Problem Pregnancies remains your go-to choice for authoritative guidance on managing today’s obstetric patient. International experts put the latest knowledge in this specialty at your fingertips, with current and relevant information on everything from fetal origins of adult disease, to improving global maternal health, to important topics in day-to-day obstetrical practice. Highly readable, well-illustrated, and easy to understand, this bestselling obstetrics reference is an ideal tool for residents and clinicians. Take advantage of the collective wisdom of global experts in the field, including two new editors— Drs. Vincenzo Berghella and William Grobman -- and nearly 30 new contributors. Gain a new perspective on a wide range of today's key issues - all evidence-based and easy to read. Sweeping updates throughout including four new chapters: ‘Vaginal Birth after Cesarean Delivery’; ‘Placenta Accreta’; ‘Obesity’; and ‘Improving Global Maternal Health: Challenges and Opportunities’ New Glossary of the most frequently used key abbreviations for easy reference Expanded use of bolded statements and key points as well as additional tables, flow diagrams, and bulleted lists facilitates and enhances the mastery of each chapter More than 100 images in the Obstetrical Ultrasound chapter provide an important resource for normal and abnormal fetal anatomy
The world's most comprehensive, well documented, and well illustrated book on this subject. With extensive subject and geographic index. 20 photographs and illustrations - many color. Free of charge in digital PDF format.
The world's most comprehensive, well documented, and well illustrated book on this subject. With extensive subject and geographic index. 245 photographs and illustrations - mostly color. Free of charge in digital format on Google Books
This book undertakes a general framework within which to consider the complex nature of the writing task in English, both as a first, and as a second language. The volume explores varieties of writing, different purposes for learning to write extended text, and cross-cultural variation among second-language writers. The volume overviews textlinguistic research, explores process approaches to writing, discusses writing for professional purposes, and contrastive rhetoric. It proposes a model for text construction as well as a framework for a more general theory of writing. Later chapters, organised around seventy-five themes for writing instruction are devoted to the teaching of writing at the beginning, intermediate, and advanced levels. Writing assessment and other means for responding to writing are also discussed. William Grabe and Robert Kaplan summarise various theoretical strands that have been recently explored by applied linguists and other writing researchers, and draw these strands together into a coherent overview of the nature of written text. Finally they suggest methods for the teaching of writing consistent with the nature, processes and social context of writing.
The second of three volumes. The Civil War's Peninsula Campaign (March through July 1862) was the first large-scale Union operation in Virginia to capture the Confederate capital at Richmond. The operation was organized and led by Maj. Gen. George B. McClellan, whose amphibious turning operation was initially successful in landing troops at the tip of the Virginia peninsula against the cautious Confederate Gen. Joseph E. Johnston. When Johnston was wounded at Seven Pines at the end of May outside Richmond, however, Gen. Robert E. Lee was elevated to command the Army of Northern Virginia. His subsequent major offensive to defeat The Army of the Potomac during the Seven Days' Battles turned the tide of the campaign and the entire momentum of the war in the Eastern Theater. Original well-researched and written essays by leading scholars in the field on a wide variety of fascinating topics. Contains original maps, photos, and illustrations.
The new edition of this classic reference offers a problem-based approach to pediatric diseases. It encompasses almost all pediatric subspecialties and covers every pediatric disease and organ system. It includes case studies and over 750 lavish illustrations.
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