During the past 5 years rapid progress has been made in the understanding of biochemical pathways for signal transduction in lymphocyte activation. Gene cloning technology has been instrumental in defining and making available in pure form of a number of growth and differentiation factors, in the characterization of their receptors, and in the delineation of genes for the T cell receptor. This book is divided into 6 sections. Section 1 deals with the molecular structure of the T cell receptor. Section 2 discusses the role of the T cell receptor, membrane ion channels and biochemical pathways of signal transduction in T cell activation. The molecular structures and biological and immunological effects of interleukin 1, interleukin 2 and interleukin 3 are presented in Section 3. This section also details the structure of interleukin 2 receptor and its use as a target for therapy for certain leukemias. Section 4 includes the biochemical events which occur following the delivery of the signal for B cell activation, proliferation, and differentiation by antigen, growth/differentiation factors. The molecular structure of B cell stimulating factors is also discussed. The role of oncogene expression in cellular activation and differentiation is included in Section 5. The cellular and molecular basis of natural killing and the molecular basis of cyc1osporin A-mediated immunosuppression are discussed in detail in Section 6. We hope this book will serve as a reference work on basic mechanisms of lymphocyte activation, proliferation, and differentiation for immunologists and molecular biologists.
This volume provides a history of the computer which now comes properly up to the ubiquitous age, with new chapters that look at globalization, platformitization and regulation, allowing readers to engage with the more recent takeover by computers in their historical perspective. With the growing ubiquity of computers, the subject is one of interest to many students and this will feature in history of science and technology courses, and world history courses as well as ones specifically on computing. Books on the history of computing tend to be quite technically or business focused, this covers the social and cultural history as well.
First published in 1926, this book remains the best and most comprehensive guide to the Celtic place-names of Scotland and is essential reading for anyone interested in Scottish history and the derivations of place-names the length and breadth of the country. It is divided into sections dealing with early names, territorial divisions, general surveys of areas and also looks at saints, church terms and river names. As the standard reference work on the subject it has never been surpassed. This edition contains a new introduction which includes biographical material about the author, together with corrigenda and addenda.
The Wrist: Diagnosis and Operative Treatment, Second Edition is the most comprehensive text and reference on diagnosis and treatment of wrist disorders. Written by world-renowned experts from the Mayo Clinic and other leading institutions, this definitive text covers examination techniques for the wrist and diagnosis and treatment of fractures, dislocations, carpal instability, distal radius injuries, rheumatoid problems, soft tissue disorders, and developmental problems. The treatment chapters provide extensive coverage of current surgical techniques. More than 3,000 illustrations complement the text. This thoroughly updated Second Edition has many new contributors, including several international wrist investigators. New chapters cover wrist outcome assessment scores; treatment subtypes for carpal instability (tenodesis/capsulodesis and intercarpal fusions); denervation procedures; acute and chronic instability of the distal radioulnar joint; and evaluation and treatment of axial forearm instability (Essex-Lopresti lesion). A companion website includes the fully searchable text and an image bank.
Widely recognized as the gold standard text in hand, wrist, and elbow surgery, Green’s Operative Hand Surgery, 7th Edition, by Drs. Scott Wolfe, William Pederson, Robert Hotchkiss, Scott Kozin, and Mark Cohen, continues the tradition of excellence. High-resolution photos, innovative videos, new expert authors, and more ensure that Green’s remains your go-to reference for the most complete, authoritative guidance on the effective surgical and non-surgical management of upper extremity conditions. Well-written and clearly organized,it remains the most trusted reference in hand surgery worldwide Thoroughly revised indications and techniques to treat the full spectrum of upper extremity disorders New approaches to wrist and elbow arthroplasty, new methods for internal fixation, and new options for congenital differences Innovative, high-resolution videos that provide step-by-step guidance on key procedures, and high-resolution color photos throughout A revamped pediatric section that includes recent advances in fracture management and congenital reconstruction 14 new authors that offer fresh perspectives and preferred methods on even your toughest clinical challenges New case-based controversies and unique solutions, plus current views on what works and what does not, based on recent science and outcome measures State-of-the-art coverage of hot topics such as nerve transfers to enhance patient outcomes, elbow fracture management and reconstruction with repair and prosthetic replacement, new techniques in wrist fracture fixation, repair and reconstruction of the scapholunate ligament, management of flexor tendon injury, and much more Complete, updated coverage of the elbow – everything from trauma and arthritis to arthroscopy, reconstruction, and thrower's elbow Thoroughly revised indications and techniques to treat the full spectrum of upper extremity disorders New approaches to wrist and elbow arthroplasty, new methods for internal fixation, and new options for congenital differences Innovative, high-resolution videos that provide step-by-step guidance on key procedures, and high-resolution color photos throughout A revamped pediatric section that includes recent advances in fracture management and congenital reconstruction 14 new authors that offer fresh perspectives and preferred methods on even your toughest clinical challenges New case-based controversies and unique solutions, plus current views on what works and what does not, based on recent science and outcome measures State-of-the-art coverage of hot topics such as nerve transfers to enhance patient outcomes, elbow fracture management and reconstruction with repair and prosthetic replacement, new techniques in wrist fracture fixation, repair and reconstruction of the scapholunate ligament, management of flexor tendon injury, and much more Complete, updated coverage of the elbow – everything from trauma and arthritis to arthroscopy, reconstruction, and thrower's elbow
The world's most comprehensive, well documented, and well illustrated book on this subject. With extensive subject and geographic index. 47 photographs and illustrations - mostly color. Free of charge in digital PDF format.
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