The race is on to find a wormhole that’s the key to wealth and power in this novel by the New York Times–bestselling author of the Sam McCade series. Somewhere, deep in the vast blackness of space, a wormhole waits to be found. Dorn Voss needs to find it. But, the stakes are high and he isn’t the only one looking. Natural occurring wormholes are the lone means of intergalactic travel in the universe. Whoever controls them gains riches and power unimaginable. The coordinates of one such wormhole, the Mescalaro Gap, are lost, hidden behind conspiracy and murder. With a prize so great, many a man or alien would do anything to find those coordinates and control the universe. In Where the Ships Die, author William C. Dietz creates a dense adventure filled with complex characters and multiple storylines all crashing headlong towards one final confrontation.
The Wrist: Diagnosis and Operative Treatment, Second Edition is the most comprehensive text and reference on diagnosis and treatment of wrist disorders. Written by world-renowned experts from the Mayo Clinic and other leading institutions, this definitive text covers examination techniques for the wrist and diagnosis and treatment of fractures, dislocations, carpal instability, distal radius injuries, rheumatoid problems, soft tissue disorders, and developmental problems. The treatment chapters provide extensive coverage of current surgical techniques. More than 3,000 illustrations complement the text. This thoroughly updated Second Edition has many new contributors, including several international wrist investigators. New chapters cover wrist outcome assessment scores; treatment subtypes for carpal instability (tenodesis/capsulodesis and intercarpal fusions); denervation procedures; acute and chronic instability of the distal radioulnar joint; and evaluation and treatment of axial forearm instability (Essex-Lopresti lesion). A companion website includes the fully searchable text and an image bank.
With our American Philosophy and Religion series, Applewood reissues many primary sources published throughout American history. Through these books, scholars, interpreters, students, and non-academics alike can see the thoughts and beliefs of Americans who came before us.
Diverse alterations of glycosylation occur in diseases such as cancer, metastasis, leukemia, inflammatory and other diseases. The glycosylation abnormalities found in disease are the result of complex rearrangements of the oligosaccharide assembly by glycosyltransferases. This volume reviews several mechanisms that may underly the extremely complex alterations in disease. Disease specific glycosylation may contribute to the disease process by altering cellular functions, or may be exploited therapeutically. Specific therapy may be aimed at correcting glycosylation abnormalities based on knowledge of the mechanisms leading to the disease phenotype and the three-dimensional interactions between carbohydrates and carbohydrate-binding molecules.
Largely reorganised and much expanded in this second edition, Practice and Procedures brings together in a single volume general methods of pain assessment and presents the wide range of therapies that can be provided by a range of health care disciplines. Authored by a multidisciplinary team of experts, chapters can stand alone for readers looking for a general overview of the methods of techniques for pain management available to them or work to complement chapters in the preceeding three volumes, providing practical procedures and applications in the management of acute, chronic and cancer pain. The book is divided into three parts. Part One covers the principles of measurement and diagnosis, including history taking and examination, the selection of pain measures, diagnostic tests and novel imaging techniques. Part Two discusses the full range of therapeutic protocols available, from pharmacological therapies, through psychological techniques, physical therapy and international procedures, to techniques specific to pain assessment and management in paediatric patients. Part Three provides information on planning, conducting, analysing and publishing clinical trials, with invaluable guidance on the techniques of systematic review and meta-analysis in pain research. Part Four considers the role of multidisciplinary pain management teams, their organization, their place within different health care systems, and how best to manage change when implementing such a service. Part Five concludes the volume, investigating the use of guidelines, standards and quality improvement initiatives in the management of post-operative pain, and discussing the expert medicolegal report.
Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Largely reorganised and much expanded in this second edition, Practice and Procedures brings together in a single volume general methods of pain assessment and presents the wide range of therapies that can be provided by a range of health care disciplines. Authored by a multidisciplinary team of experts, chapters can stand alone for readers looking
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