This collection by longtime fantasy and science fiction writer William F. Wu includes triple-award finalist “Wong’s Lost and Found Emporium,” which was adapted into a Twilight Zone episode in 1985, and eight more stories of magical places, events, and spirits. Many of the stories involve issues regarding Americans of Chinese descent, and all involve universal concerns. ~~~~~ PG Excerpt ~~~~~ “What’s wrong with you?” she demanded. “I want to know! Why are you so callous?” She snatched up the metal container from the floor in front of me and held it wrapped in her shawl. “Tell me now!” she screamed, right in front of me. I leaned forward and spoke, glaring into her eyes. “I came in here looking for my compassion. I lost it years ago, bit by bit. I lost it when I was eight, and other kids chased me around the playground for no visible reason—and they weren’t playing. When I started junior high and got beat up in gym class because the rest of the school was white, like my grade school. When I ran for student congress and had my posters covered with swastikas and KKK symbols. And that was before I got out into the world on my own. You want to hear about my adult life?” I paused to catch my breath. She backed away from me. “I’ve lost more of my compassion every year of my life for every year I can remember, until I don’t have any more. Well, it’s here, but I can’t find it.” She stood speechless in front of me. Letting her have it all at once accomplished that much, at least. “Maybe you were in the wrong town,” she muttered. “You think I like being like this? Hating the memories of my life and not caring what happens to anybody? I said I’ve lost my compassion, not my conscience.” She walked back and put the metal bottle back in its place on the shelf. “I can find it,” she said quietly. “What?” “I’ve been watching you. When you get something for someone, you follow the little white light that appears.” “You can see that?” “Of course I can—anybody can. You think you’re special? We just can’t see our own. I figured that out.” “Well…so did I,” I said lamely. “So, I could get your compassion for you.” “Yeah?” I didn’t think she would, considering all she’d said. “Only you have to get what I want, first.” “You don’t trust me, remember?” She smiled smugly. It looked grotesque, as though she hadn’t smiled in ages. “I can trust you. Because you know that if you don’t give me what I want, I won’t give you your compassion. Besides, if all goes well, your lack of compassion won’t make any difference.” “Well, yeah. I guess so.” I hadn’t considered a deal with another customer before. Until now, I had just been waiting for the no-show proprietor, and then had given up even on that. “Well?” she demanded, still with that weird forced smile. “Uh—yeah, okay.” It was my last chance. I glanced around and found her spot of white light behind me on a lower shelf. “This way.” She walked next to me, watching me carefully as the white light led us down the crowded aisle. A large porcelain vase emitted guttural mutterings on an upper shelf as we passed. Two small lizards from the Florida corridor and something resembling a T-bone steak with legs were drinking at a pool of shiny liquid in the middle of the floor. The viscous liquid was oozing slowly out of a cracked green bottle. We stepped over it and kept going. The light finally stopped on the cork of a long-necked blue bottle at the back of a bottom shelf. I stopped and looked down at it, wondering if this deal had an angle I hadn’t figured.
The Hugo- and Nebula-nominated story "Hong's Bluff" leads this new collection of science fiction stories by longtime writer William F. Wu. Some stories are light-hearted and others dramatic, about alternate worlds, cyborgs, clones, nanotech, war-games, and life in space, often with subjects involving Americans of Chinese descent. A new introduction and afterword to each story enhance this book. ~~~~~ Excerpt ~~~~~ In the glare of the spotlight, Daniel Zisuey Eng stood on the high dais in the Temple of Eng Zisuey, wearing his traditional black Chinese robe of embroidered silk and a white undertunic. Now at the end of the ritual, he watched the crowd standing far below him. The sweet smoke of incense wafted past, mixed with acrid smoke left by firecrackers set off earlier. ?Farewell,? Daniel?s voice boomed in English over the speakers. From the traditional Chinese orchestra, the fast banging of a light-weight gong built to a crescendo. Those below gazed up at Daniel in awe, curiosity, or skepticism, the majority of them also surnamed Eng. A few shouted insults; others called entreaties, even prayers. He calmly remained behind the altar of carved teak that was now covered with sacrifices of cash, pledges, jewelry, even children?s toys. ?Yi lu ping an,? Daniel intoned in Mandarin, wishing the crowd a peaceful journey. ?Yet lu ping on,? he repeated in Cantonese. As always, Daniel waited for a line of acolytes to form below the dais so no one could jump the rail and climb up to him. At the gong?s final crash, the spotlight went out, signaling the end of the ritual. In the sudden darkness, he whirled and strode off the dais, stage right. Twenty-eight years old, Daniel had been worshipped as a spirit reborn for nearly all of his adult life. ***** ??Nother day, ?nother dollar, Danny-boy.? At Daniel?s dressing-room door, Eric Leitch, the tall, brawny Chief of Personal Security, smirked at Daniel as he spoke in his Aussie-accented English, his sun-bleached flat-top standing stiff over his broad, square-jawed face. ?The acolytes are escortin? the crowd out in order; A-Okay, green lights all ?round.? ?Good,? Daniel muttered in annoyance, palming the doorplate to slip inside and close it again. He had no liking for his blue-uniformed Personal Security bodyguards. Even the acolytes were guards who wore traditional robes over their uniforms during the rituals. Chief Leitch spent most of his shift watching the temple grounds on monitors in his office. His unit worked for Mr. Eng Sen, as Daniel did?his nominal grandfather, a tycoon whose business empire owned Eng Zhouxian Do, this island near Hong Kong. The light came on in Daniel?s lavish dressing room at the rear of the temple??backstage,? in the jargon of his UCLA major in Theater Arts. A man?s voice, dry with age, came on the room?s speakers in Cantonese. ?Ah Suey, are you there? Keep your stage makeup on.? ?I?m here,? Daniel answered in the same language, recognizing Eng Sen?s voice. ?Screen on.? He flopped down in a tan leather-covered recliner, tired as always from the evening?s effort. The far wall brightened with the video image of the man he called ?Grandfather.? Seventy-two years old, Eng Sen wore his white hair short and had age spots removed by laser treatment. His bland, roundish face smiled with cold courtesy from a high, black leather chair; sunlight backlit him like a halo. ?I?m calling from my London office, Ah Suey. Remain in costume; I?ve instructed a new assistant of mine to bring visitors to you even as we speak.? ?A major sacrifice, Grandfather?? Daniel fought to keep disgust out of his voice as he pushed up from the recliner. ?My assistant, Meilin Lei, will handle the financial matters.? ?I know what to do, Grandfather,? Daniel said obediently.
ÿA young guy named Jack Hong hitchhikes throughout America following the keilin, a mystical unicorn out of Chinese mythology. The keilin leads him to ten adventures with ghosts and other supernatural figures. These experiences reveal to him not only parts of American history he never knew, but also his own identity and the role he will choose for his life. ~~~~~ Description ~~~~~ The moonlight was still strong, and Lo Man Gong still sat up on the overhead window, where few people and no old men could ever get.?Feel better, Chinaman?? he asked mildly.The night before, my resistance had been low, and his presence had somehow seemed tolerable, if not rational. Now I was more clear-headed ... yet he was still here. I didn?t like him as much.I let my eyes drop closed again. Once I was cured of malaria, I?d be free of him. I had eaten twice today; now, if I slept well, I?d be in sound shape pretty soon.?You know the keilin, Chinaman Jack??That was the Chinese unicorn, a mystical animal whose rare appearances were highly auspicious. In the Cantonese I normally heard, it was pronounced ?keilun.? It wasn?t like European ones, though. This unicorn had the body of a deer, the hooves of a horse, the tail of an ox, and a fleshy horn. I knew that much.?The unicorn?? I opened my eyes and looked at him. As before, the moonlight glowed through his shape.?Ah, you know the keilin. He smiled and nodded thoughtfully. ?The keilin means good things happen. It?s very powerful.?I watched him silently.After a while, he looked into my eyes again. ?Nobody remember me, Jack. Some people remember, some of my frien?. A few of them. Most, nobody remember at all. No children, no relative. You, Jack. You like me. Unless you change.?Yes, I knew that. I had already come to understand that. And I knew that he had come for me, here in the middle of the country, away from his home as longtime Californ?. But I didn?t know why.
ODE/PDE Alpha-Synuclein Models for Parkinson’s Disease discusses a mechanism for the evolution of Parkinson’s Disease (PD) based on the dynamics of the protein a-synuclein, a monomer that has been implicated in this disease. Specifically, a-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the a-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms Includes PDE routines based on the method of lines (MOL) for computer-based implementation of ODE/PDE models Offers transportable computer source codes for readers, with line-by-line code descriptions relating to the mathematical model and algorithms Authored by a leading researcher and educator in ODE/PDE models
A handy reference in one single volume of the key institutions and profound changes over the last three decades that transformed China into a global power.
This study examines the way Americans of Chinese descent were portrayed in American literature between 1850 and 1940. Their depictions are compared to historical events that were occurring at the time the works of literature were published. This edition has additions and corrections compared to the original hardback edition published in 1982. ~~~~~ Excerpt ~~~~~ My purpose in writing this work has been to explore the depiction of Chinese immigrants and their descendants in American fiction, from the mid-nineteenth century entry of the first Chinese immigrants in significant numbers, to the eve of World War II. I consider both the immigrant Chinese and the American-born generations that followed them to be Chinese Americans, but will sometimes identify the groups separately in recognition of the fact that the historical experience and treatment of the immigrants in fiction has been different from that of their descendants. The fiction treated in this study includes short stories and novels both by white Americans and Asian Americans. I am defining the term Yellow Peril as the threat to the United States that some white American authors believed was posed by the people of East Asia. As a literary theme, the fear of this threat focuses on specific issues, including possible military invasion from Asia, perceived competition to the white labor force from Asian workers, the alleged moral degeneracy of Asian people, and the potential genetic mixing of Anglo-Saxons with Asians, who were considered a biologically inferior race by some intellectuals of the nineteenth century. The Chinese immigrants were the first target of this attention, since they were the first Asian immigrants to reach the United States in large numbers. This study will focus on American fiction about Chinese Americans in an attempt to analyze the growth and development of attitudes about them. My thesis is that the Yellow Peril is the overwhelmingly dominant theme in American fiction about Chinese Americans in the years with which this study is concerned. It is expressed through the variety of images of the Chinese Americans that appear, especially in their relation to, and their role as part of, the United States. The historical causes and literary subject matter change, but the theme neither disappears nor abates. Each work of fiction has been studied individually for the images it contains. Prior to the turn of the century, the Yellow Peril is perceived only as stemming from the Chinese. In the twentieth century, especially in the pulps, the Japanese joined the Chinese as a perceived menace to Europe and North America. The overall process of evaluation relies primarily on detailed analyses of the characters under consideration. This has been done with an awareness that the American public as a whole sometimes did not distinguish carefully among Asian ethnic groups, so that events involving one Asian ethnic group often affected the image of another. Some works are obscure and these have been quoted at greater length than more available ones. Relatively few critical sources have been cited; this is due to a dearth of relevant studies. The less important works of fiction have naturally received little critical attention and, often, when such attention was concerned with pertinent stories, the authors had little or nothing to say about the depiction of Chinese Americans. This observation is intended only as an explanation, and not as a value judgement of earlier scholarship with different goals.
An original collection of interwoven short stories set in the Wild Cards universe, where an alien virus mutates some and grants superpowers to others, created by the #1 New York Times bestselling author of A Game of Thrones An alien virus ravages the world, with effects as random as a hand of cards. Those infected either draw the black queen and die, draw an ace and receive superpowers, or draw the joker and are bizarrely mutated. Croyd Crenson is the Wild Card’s greatest failure—and its greatest success. Dubbed “The Sleeper,” he randomly undergoes hibernations that can span days, weeks, or even months. After each hibernation, he awakens with a new appearance and set of powers—sometimes a joker, sometimes an ace, and sometimes a combination of both—until exhaustion claims him and his next inevitable sleep shuffles the cards anew. Ever since his initial infection in 1946, he’s awoken in a singular body—until now. His latest awakening has left him split into six different incarnations, each of them a self-contained piece of the original and each with a unique look and ability. One of them, at least, recognizes this for the disaster that it is, and tasks the clever and elusive Tesla—a joker with ace powers—to locate and gather the remaining five versions of himself before sleep claims them again and leaves Croyd permanently fractured. What follows is a journey through Croyd’s long and colorful life, through the lens of some who have encountered the world’s most unusual wild carder. And as Tesla delves deeper into the investigation, he’ll have to work fast, because not every Croyd is as amiable as the first—and they’ll do whatever it takes to survive. Featuring stories from: Christopher Rowe • Carrie Vaughn • Cherie Priest • William F. Wu • Walter Jon Williams • Stephen Leigh • Mary Anne Mohanraj • Max Gladstone • Edited by George R. R. Martin • Assisted by Melinda M. Snodgrass
From the 1898 Martian Siege of Baltimore to a forlorn AI attack dog on the blue-star-scarred surface of MZ458-C and from the merc-manned Freestead Mayflower off the coast of post-apocalyptic Portland to the man-desperate shores of the Red Sea, here are seventeen science fiction stories of valiant endurance. These heroes battle conspiracies of usurpers, confront the unearned consequences of others’ willful lunacy, seek out buried truths at unbearable personal expense and endure the inhuman demands of digital rebellion in worlds innately hostile to truth and freedom. With original, never-before-published works from veteran authors, including William F. Wu, as well as emerging talents.
The Hugo- and Nebula-nominated story "Hong's Bluff" leads this new collection of science fiction stories by longtime writer William F. Wu. Some stories are light-hearted and others dramatic, about alternate worlds, cyborgs, clones, nanotech, war-games, and life in space, often with subjects involving Americans of Chinese descent. A new introduction and afterword to each story enhance this book. ~~~~~ Excerpt ~~~~~ In the glare of the spotlight, Daniel Zisuey Eng stood on the high dais in the Temple of Eng Zisuey, wearing his traditional black Chinese robe of embroidered silk and a white undertunic. Now at the end of the ritual, he watched the crowd standing far below him. The sweet smoke of incense wafted past, mixed with acrid smoke left by firecrackers set off earlier. ?Farewell,? Daniel?s voice boomed in English over the speakers. From the traditional Chinese orchestra, the fast banging of a light-weight gong built to a crescendo. Those below gazed up at Daniel in awe, curiosity, or skepticism, the majority of them also surnamed Eng. A few shouted insults; others called entreaties, even prayers. He calmly remained behind the altar of carved teak that was now covered with sacrifices of cash, pledges, jewelry, even children?s toys. ?Yi lu ping an,? Daniel intoned in Mandarin, wishing the crowd a peaceful journey. ?Yet lu ping on,? he repeated in Cantonese. As always, Daniel waited for a line of acolytes to form below the dais so no one could jump the rail and climb up to him. At the gong?s final crash, the spotlight went out, signaling the end of the ritual. In the sudden darkness, he whirled and strode off the dais, stage right. Twenty-eight years old, Daniel had been worshipped as a spirit reborn for nearly all of his adult life. ***** ??Nother day, ?nother dollar, Danny-boy.? At Daniel?s dressing-room door, Eric Leitch, the tall, brawny Chief of Personal Security, smirked at Daniel as he spoke in his Aussie-accented English, his sun-bleached flat-top standing stiff over his broad, square-jawed face. ?The acolytes are escortin? the crowd out in order; A-Okay, green lights all ?round.? ?Good,? Daniel muttered in annoyance, palming the doorplate to slip inside and close it again. He had no liking for his blue-uniformed Personal Security bodyguards. Even the acolytes were guards who wore traditional robes over their uniforms during the rituals. Chief Leitch spent most of his shift watching the temple grounds on monitors in his office. His unit worked for Mr. Eng Sen, as Daniel did?his nominal grandfather, a tycoon whose business empire owned Eng Zhouxian Do, this island near Hong Kong. The light came on in Daniel?s lavish dressing room at the rear of the temple??backstage,? in the jargon of his UCLA major in Theater Arts. A man?s voice, dry with age, came on the room?s speakers in Cantonese. ?Ah Suey, are you there? Keep your stage makeup on.? ?I?m here,? Daniel answered in the same language, recognizing Eng Sen?s voice. ?Screen on.? He flopped down in a tan leather-covered recliner, tired as always from the evening?s effort. The far wall brightened with the video image of the man he called ?Grandfather.? Seventy-two years old, Eng Sen wore his white hair short and had age spots removed by laser treatment. His bland, roundish face smiled with cold courtesy from a high, black leather chair; sunlight backlit him like a halo. ?I?m calling from my London office, Ah Suey. Remain in costume; I?ve instructed a new assistant of mine to bring visitors to you even as we speak.? ?A major sacrifice, Grandfather?? Daniel fought to keep disgust out of his voice as he pushed up from the recliner. ?My assistant, Meilin Lei, will handle the financial matters.? ?I know what to do, Grandfather,? Daniel said obediently.
A biography of the scientist who spent 30 years in China as a Methodist educator, a Rockefeller official in Beijing, and as a biological researcher, exemplifies Sino-American interaction during the first half of the century. Haas (history, Fort Lewis College) surrounds his themes with the rich atmosphere of China during the period, detailing the interplay between religious and secular belief systems encountered by Gee in the educational institutions and in the culture. Annotation copyright by Book News, Inc., Portland, OR
In the New York Times–bestselling author’s epic fantasy sequel to A Hero Born, a new power arises as chaos overtakes Reality. As a Chaos Rider, Locke ventured into the realm where time and change rage out of control. Though he set out to find his lost father, he must now become the hero he has been seeking. The Seal of Reality has been broken, and the Wildness that was once kept at bay is unleashed upon the world. Behind this devastation is an evil more ancient and more awesome than Fialchar himself. The only hope of defeating this new Darkness is with an unlikely alliance of Empire and Chaos forces, led by an untried swordsman from beyond time. An Enemy Reborn is the final installment of the Realms of Chaos duology.
This monograph aims at presenting a unified approach to numerical modeling of tsunami as long waves based on finite difference methods for 1D, 2D and 3D generation processes, propagation, and runup. Many practical examples give insight into the relationship between long wave physics and numerical solutions and allow readers to quickly pursue and develop specific topics in greater depth. The aim of this book is to start from basics and then continue into applications. This approach should serve well the needs of researchers and students of physics, physical oceanography, ocean/civil engineers, computer science, and emergency management staff. Chapter 2 is particularly valuable as it fully describes the application of finite-difference methods to the study of long waves by demonstrating how physical properties of water waves, especially phase velocity, are connected to the chosen numerical algorithm. Basic notions of numerical methods, i.e. approximation of the relevant differential equations, stability of the numerical scheme, and computational errors are explained through application to long waves. Finite-difference methods are further developed in major chapters to deal with complex problems that arise in the study of recent tsunamis.
Longtime science fiction writers Rob Chilson and William F. Wu collaborated on these ten stories, all of which first appeared in Analog Science Fiction and Fact magazine. Chilson is especially known for his work in Analog, as is Wu, a finalist for multiple Hugo and Nebula awards. This collection is enhanced by their light-hearted, informative introduction and afterwords to each story. ~~~~~ Excerpt ~~~~~ Roger was dozing in his seat when he felt the familiar small hands and bony knees of his daughter climbing into his lap. He opened his eyes and put one arm around her; she, in turn, had one firm arm around Buffalo Bill?s neck. ?Hi, sweetie,? he said, his voice hoarse. ?Something the matter?? Marta looked solemnly out into the starry night. The car seemed to be hovering motionless in the sky. A strange black sky, with no ground visible. Earth was invisible far below them; it could not be seen through any of their windows. They had flown out of the shadow of Earth, thrown by their retained rotational velocity. Now Roger would keep the sun under them, charge the hull with electricity to ward off the solar wind, and pray. The thermo-electric elements kept the car cool enough, but the floor and walls were warm to the touch. The windows were edged with flame from the sunlight below. ?Where are we?? Marta asked. Roger cleared his throat. ?We?re nearly halfway to the moon, sweetie.? Luna was visible off to the right, as if on the horizon. ?Oh.? She considered the stars thoughtfully. Finally, unexpectedly, she asked, ?Are we going to be like the tigers?? Startled, Roger laughed. ?Sure. You like that one?? He used a light tone, to see if she would turn playful. Marta nodded, meeting his gaze solemnly. Sobering, Roger recited: ?The mind desires to roam, The soul aspires to soar, But Earth?s a fettered prison Without freedom?s ancient lore. My seeking mind turns outward To tropic jungles and the night, Where cold-eyed tigers freely prowl To hunt and dream and smite.? Marta said sleepily, ?It?s always night out here,? and touched her nose to his. He kissed her cheek. ?Do you know one about buffaloes?? she asked, cuddling. ?Uh, yeah, I know a song about where buffalo roam. Or used to, at least. Shall I teach it to you?? ?Yeah!? ?Okay.? Roger paused to get the lyrics straight and as he did, he reflected that buffaloes had been confined to zoos and parks even longer than tigers. ?Oh, give me a home?.? As he sang and cuddled his daughter, Roger brooded over his position and course. He had been brooding over the course for days. They were approaching turnover time for travel to the Moon or Ell Clusters, and still piling on gee. Luna, of course, was nowhere near his line of flight. He would pass near the L-4 Cluster as space distances go, but it would scarcely be visible. The transponder had beeped occasionally? it sounded off audibly when tweaked by questing beams, even as it responded. Now Roger shut off its responses. To have come out without filing a flight plan or with a silent transponder would have been a giveaway; the Patrol would have been all over him at once. Now, though, maybe he had left it on too long. As it was, the transponder had beeped every fifteen minutes or so since he had first been warned of his deviation from his LEO destination. They knew where he was, how fast he was accelerating, and in what direction. Where were they? Roger hugged his daughter, sang louder as she joined in the chorus. He couldn?t help glancing around at all the windows, expecting to see the prow of a CisLunar Patrol ship, evil menace incarnate, loom near them. If they caught him, he would lose his daughter. He could think of nothing else to do. He could only run.
This collection by longtime fantasy and science fiction writer William F. Wu includes triple-award finalist “Wong’s Lost and Found Emporium,” which was adapted into a Twilight Zone episode in 1985, and eight more stories of magical places, events, and spirits. Many of the stories involve issues regarding Americans of Chinese descent, and all involve universal concerns. ~~~~~ PG Excerpt ~~~~~ “What’s wrong with you?” she demanded. “I want to know! Why are you so callous?” She snatched up the metal container from the floor in front of me and held it wrapped in her shawl. “Tell me now!” she screamed, right in front of me. I leaned forward and spoke, glaring into her eyes. “I came in here looking for my compassion. I lost it years ago, bit by bit. I lost it when I was eight, and other kids chased me around the playground for no visible reason—and they weren’t playing. When I started junior high and got beat up in gym class because the rest of the school was white, like my grade school. When I ran for student congress and had my posters covered with swastikas and KKK symbols. And that was before I got out into the world on my own. You want to hear about my adult life?” I paused to catch my breath. She backed away from me. “I’ve lost more of my compassion every year of my life for every year I can remember, until I don’t have any more. Well, it’s here, but I can’t find it.” She stood speechless in front of me. Letting her have it all at once accomplished that much, at least. “Maybe you were in the wrong town,” she muttered. “You think I like being like this? Hating the memories of my life and not caring what happens to anybody? I said I’ve lost my compassion, not my conscience.” She walked back and put the metal bottle back in its place on the shelf. “I can find it,” she said quietly. “What?” “I’ve been watching you. When you get something for someone, you follow the little white light that appears.” “You can see that?” “Of course I can—anybody can. You think you’re special? We just can’t see our own. I figured that out.” “Well…so did I,” I said lamely. “So, I could get your compassion for you.” “Yeah?” I didn’t think she would, considering all she’d said. “Only you have to get what I want, first.” “You don’t trust me, remember?” She smiled smugly. It looked grotesque, as though she hadn’t smiled in ages. “I can trust you. Because you know that if you don’t give me what I want, I won’t give you your compassion. Besides, if all goes well, your lack of compassion won’t make any difference.” “Well, yeah. I guess so.” I hadn’t considered a deal with another customer before. Until now, I had just been waiting for the no-show proprietor, and then had given up even on that. “Well?” she demanded, still with that weird forced smile. “Uh—yeah, okay.” It was my last chance. I glanced around and found her spot of white light behind me on a lower shelf. “This way.” She walked next to me, watching me carefully as the white light led us down the crowded aisle. A large porcelain vase emitted guttural mutterings on an upper shelf as we passed. Two small lizards from the Florida corridor and something resembling a T-bone steak with legs were drinking at a pool of shiny liquid in the middle of the floor. The viscous liquid was oozing slowly out of a cracked green bottle. We stepped over it and kept going. The light finally stopped on the cork of a long-necked blue bottle at the back of a bottom shelf. I stopped and looked down at it, wondering if this deal had an angle I hadn’t figured.
Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. Stay fully up to date in this fast-changing field with Nephrology and Fluid/Electrolyte Physiology, 3rd Edition. New chapters on Inherited Disorders of Calcium, Phosphate and Magnesium; Fluid and Electrolyte Management of High Risk Infants; Renal Development and Molecular Pathogenesis of Renal Dysplasia; and Prenatal Programming, which describes how prenatal insults can result in hypertension, kidney and cardiovascular disease. The most current clinical information, including new content on the molecular basis for hereditary tubulopathies and inherited disorders of calcium, phosphate, and magnesium homeostasis. New information on genetics and pharmacology, neonatal hypertension, diuretic use in the newborn, prenatal programming of adult diseases, lung fluid balance, and much more. Consistent chapter organization to help you find information quickly and easily. The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set! Gastroenterology and Nutrition Hematology, Immunology and Genetics Hemodynamics and Cardiology Infectious Disease and Pharmacology New Volume! Nephrology and Fluid/Electrolyte Physiology Neurology The Newborn Lung
Now in a single, convenient volume, The Breast: Comprehensive Management of Benign and Malignant Diseases, 5th Edition covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. Building upon the strengths of previous editions, this updated volume by Drs. Kirby I. Bland, Edward M. Copeland III, V. Suzanne Klimberg, and William J Gradishar, includes the latest innovations in breast cancer detection and treatment in a practical, easy-to-use format ideal for today’s surgeons. Delivers step-by-step clinical guidance highlighted by superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures. Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, surgeons, oncologists, and other health care professionals who contribute to the management of patients with breast disease. Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. Covers the latest developments in receptor modulation, targeted monoclonal antibodies, evolving inhibitors with triple-negative disease, and more. Discusses recent minimally invasive surgical techniques and new developments in oncoplastic breast conservation techniques. Contains significant updates to the "Management of Systemic Disease" section that reflect the latest advances in chemotherapy, hormonal resistance, and therapy.
Tormented by a horrible disease, Derec must face the genius Dr. Avery and attempt to compel him to reveal the truth. When Derec discovers the shocking secret of his true identity, astounding traps and baffling mystery come to a colossal climax in the final episode of Isaac Asimov's Robot City.
Offers a compendium of information on retrosynthesis and process chemistry, featuring innovative "reaction maps" showing synthetic routes of some widely used drugs This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the "best" processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of retrosynthesis and process chemistry—in order to show how retrosynthetic analysis assists in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process. The book also uses some key concepts used by process chemists to improve efficiency to indicate the best route to select. Each chapter in Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is dedicated to one drug, with each containing information on: worldwide sales and patent status of the Active Pharmaceutical Ingredient (API); structure analysis and general retrosynthetic strategy of the API; first reported synthesis; critical analysis of the processes which have been developed and comparison of the synthetic routes; lessons learned; reaction conditions for Schemes A to X; chemical "highlights" on key reactions used during the synthesis; and references. Drugs covered include: Gabapentin, Clopidogrel, Citalopram and Escitalopram, Sitagliptin, Ezetimibe, Montelukast, and Oseltamivir. Show how the retrosynthetic tool is used by the Pharmaceutical Industry Fills a gap for a book where retrosynthetic analysis is systematically applied to active pharmaceutical ingredients (APIs) Features analyses and methodologies that aid readers in uncovering practical synthetic routes to other drug substances, whether they be NCEs (New Chemical Entities) or generic APIs (Active Pharmaceutical Ingredients) Presents information from both the patent and academic literature for those who wish to use as a basis for further study and thought Features the use of "reaction maps" which display several synthetic processes in the same scheme, and which allow easy comparisons of different routes that give the same molecule or intermediate. A selection of these maps are available to download from: https://www.wiley.com/go/santos/retrosynthesis Retrosynthesis in the Manufacture of Generic Drugs Selected Case Studies is an ideal book for researchers and advanced students in organic synthetic chemistry and process chemistry. It will also be of great benefit to practitioners in the pharmaceutical industry, particularly new starters, and those new to process chemistry.
Since publication of the First Edition in 1982, Hemostasis and Thrombosis has established itself as the pre-eminent book in the field of coagulation disorders. No other book is as inclusive in scope, with coverage of the field from the standpoint of both basic scientists and clinicians. This comprehensive resource details the essentials of bleeding and thrombotic disorders and the management of patients with these and related problems, and delivers the most up-to-date information on normal biochemistry and function of platelets or endothelial cells, as well as in-depth discussions of the pharmacology of anticoagulant, fibrinolytic, and hemostatic drugs. NEW to the Sixth Edition... • A new team of editors, each a leader in his field, assures you of fresh, authoritative perspectives. • Full color throughout • A companion website that offers full text online and an image bank. • A new introductory section of chapters on basic sciences as related to the field • Entirely new section on Hemostatic and Thrombotic Disorders Associated with Systemic Conditions includes material on pediatric patients, women's health issues, cancer, sickle cell disease, and other groups. • Overview chapters preceding each section address broad topics of general importance. This is the tablet version which does not include access to the supplemental content mentioned in the text.
Steroids in the Laboratory and Clinical Practice covers both basic chemistry and therapeutic application of steroids in a single source. The comprehensive reference addresses the specificity of steroid determinations to clarify confusion arising from the laboratory results. The book covers important advancements in the field and is a valuable addition in the literature addressing all existing knowledge gaps. This is a must have reference for pathologists, laboratorians, endocrinologists, analytical/clinical chemists and biochemists. Addresses the normal production of steroids and concentrations found in biological fluids and tissues Presents the changes in steroid concentrations at life events as reference points for clinical investigations Reviews the genetic disorders of steroids in relation to specific enzyme changes and clinical presentation
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