Since 1975, when the University of Oklahoma faculty created their review course for second-year medical students, the Oklahoma Notes have been among the most trusted and widely used reviews for the National Boards. Each Oklahoma Notes book presents the core information of one segment of the medical school curriculum. Written by some of the most effective medical educators in the country, the Oklahoma Notes feature: Concise text presented in outline format for rapid review; contents oriented to promote Boards success; self-assessment questions geared to the current format of the NBME exam; more tables and figures designed to facilitate self-assessment and review; and low-cost, complete coverage of each subject. In 1993, Springer-Verlag launched the first five Oklahoma Notes to cover the clinical sciences: General Surgery, Internal Medicine, Neurology and Clinical Neuroscience, Pediatrics, and Psychology. Obstetrics and Gynecology continues the expansion into the clinical sciences.
This issue of the Obstetrics and Gynecology Clinics in North America will focus on the advances in the evaluation and management of Recurrent Pregnancy Loss (RPL) that have emerged within the last few years. Although spontaneous pregnancy loss occurs in approximately 15% to 20% of clinically recognized pregnancies in reproductive-aged women, RPL occurs in 2% to 5% of the same population. Recent reports on large populations of women with RPL have helped to characterize the incidence and diversity of this heterogeneous disorder, and a definite cause of pregnancy loss can be established on over 50% of all couples after a thorough evaluation. New diagnostic strategies, which include 23-chromosome microarray genetic testing of the products of conception in failed pregnancies, offer the promise of understanding the cause of most pregnancy losses. These recent advances, combined with the contributions from the authors in this issue of Clinics and many others interested in this field, lead to the publication of the long-awaited publication on evaluation and treatment of RPL from the Practice Committee of the American Society for Reproductive Medicine. A complete evaluation will include investigations into genetic, anatomic, immunologic, endocrinologic, and iatrogenic factors.
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