Pharmaceutical Outsourcing: Discovery and Preclinical Services is the first in a series on pharmaceutical outsourcing. This first book is written for all practitioners in the pharmaceutical and biotech world and is about managing projects in drug discovery and preclinical development. The purpose envisioned by the authors and editors is to provide an understanding of how outsourcing works from the perspective of sponsor, internal customer, service provider, outsourcing service marketplace, principal investigator, project leader, and consultant. The authors of this book and the companies they represent hail from the Americas, Europe, Asia, and Australia, underscoring the fact that drug discovery is an international effort. The scope of the businesses covered include the one-person consulting company through to a sponsor among the largest in the industry. Written in the styles unique to each author, the reader will enjoy getting into the minds of the writer. Our intention is to provide a story for each aspect of the process as you move from target validation, genomic profiling, screening, medicinal chemistry, modeling and informatics, safety evaluation, therapeutic target confirmation, through to protecting the results of the research, the intellectual property. Emerging trends in drug discovery support a rapidly growing business model in outsourcing, the virtual pharma company. In recognition of this important element are several success stories and learnings on arbitraging risks in discovery. Outsourcing provides the ultimate flexibility in managing projects that may quickly grow, progress in directions unanticipated, or fail early. Last but not least, this book provides insights in working with companies outside your region, with business cultures unfamiliar or unknown. Relationship building is about understanding your sponsor or customer in their cultural space and being able to establish the rapport for clear and open communications. Priceless!
This is the definitive work on Americans taken prisoner during the Revolutionary War. The bulk of the book is devoted to personal accounts, many of them moving, of the conditions endured by U.S. prisoners at the hands of the British, as preserved in journals or diaries kept by physicians, ships' captains, and the prisoners themselves. Of greater genealogical interest is the alphabetical list of 8,000 men who were imprisoned on the British vessel The Old Jersey, which the author copied from the papers of the British War Department and incorporated in the appendix to the work. Also included is a Muster Roll of Captain Abraham Shepherd's Company of Virginia Riflemen and a section on soldiers of the Pennsylvania Flying Camp who perished in prison, 1776-1777.
This is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. It is fully updated with much molecular, screening and management information. It covers risk analysis and genetic counselling for individuals with a family history of cancer. It also discusses predictive testing and the organisation of the cancer genetics service. There is information about the genes causing Mendelian cancer predisposing conditions and their mechanism of action. It aims to provide such details in a practical format for geneticists and clinicians in all disciplines.
This book contains details on the men of Smith County Mississippi who served in the Civil War. There is also an account of Grierson's Raid. The following units were formed from men of Smith County.Company D 6th Miss Infantry / Company 6th Battalion/46 Miss Infantry / Company E A& C 8th Miss Infantry / Company H 16th Miss Infantry / Company C 36th Miss Infantry / Company G. 37th Miss Infantry / Company G & H 46th Miss Infantry
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