This text offers an up-to-date review of the field of cancer chemotherapy, including some of the new approaches to biological treatments of cancer and potential targets for new drug design. A detailed description of the pharmacology, mechanisms of action, toxicity, resistance mechanisms, and clinical usefulness of each class of drugs is given. The authors emphasize concepts involved in determining the mechanism of action and development of resistance, the determinants of drug responsiveness to chemotherapeutic agents, and a rationale for their clinical use in various types of cancer. The text is organized in a way that makes it easy for the reader to conceptualize how drugs work and categorize them by their mechanism of action. It facilitates an understanding of the rationale for chemotherapy with respect to the biology of the cancer cell and to tumor growth kinetics. Drawing on the fields of authors draw on the fields of medicinal chemistry, pharmacology, biochemistry, cell biology, molecular biology, and clinical medicine, this timely book is extensively referenced and provides a historical background for the development of each class of drugs.
For this updated edition, the treatment of the mechanisms of action, pharmacology and adverse effects of the drugs used to treat bacterial, fungal, parasitic and viral infections has been expanded. This edition also includes new chapters on the fluoroquinolones and drugs used to treat AIDS.
A surprisingly little-known marque today, Elcar once ranked among the finest vehicles on American roads. Built to exacting standards in Elkhart, Indiana, an Elcar could compete head-to-head on the basis of performance, quality, or price with the products of much larger manufacturers. Ultimately done in by weak distribution and the ravages of the Depression, Elcar today stands as an example of an ambitious company that transformed itself, successfully if temporarily, from a maker of buggies and harnesses into a respected car manufacturer in the early days of the automotive age. This remarkably exhaustive history, researched over several decades from all available sources, including interviews with former Elcar employees, details all Elcar models and the Pratt vehicles that preceded them, as well as the personalities behind the cars. Extensive appendices provide a complete model history, with specifications; a full corporate chronology; an illustrated accounting of all Elcars and Pratts known to survive whole or in part today; a roster of company employees; a descriptive list of all ads and brochures ever produced by the company; and a wealth of other data that can be found nowhere else. Lavishly illustrated and surpassingly thorough, this book is a well of information on a significant but forgotten line of automobiles.
Of interest to developers of virtual reality applications and others interested in potential uses for virtual reality, this book presents a selection of useful VR applications and gives readers guidance on how VR might be applied.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.