The history of Wheeling and Ohio County is both eclectic and engaging. Beginning in the colonial era when the legendary Betty Zane saved Fort Henry from an Indian attack by hiding gunpowder in her skirt, Wheeling eventually emerged as an important link between Eastern cities and the rest of the United States. The Wheeling Suspension Bridge, the Old National Road, and the B&O Railroad all passed through the bustling Ohio County. Over the years, Wheeling has been labeled everything from "Victorian Wheeling" to "Sintown USA," and these monikers represent the diverse qualities of a town molded and shaped by the steel, coal, tobacco, and transportation industries. Whether residents and visitors frequented the impressive Victorian mansions or Wheeling's infamous brothel district, they always had something to write home about. The incomparable collection showcased in this book spans five decades and was begun and continued by the Carney family.
When most people think of Wheeling they remember Independence Hall and the birth of West Virginia, but Wheeling's history goes back even further to the frontier legends of Lewis Wetzel and Maj. Samuel McColloch. Images of America: Wheeling includes photographs of both Wetzel's cave and Major McColloch's smoke house, as well as a multitude of historic photographs depicting the way life used to be in the late 19th and early 20th centuries. Famous visitors such as Babe Ruth, Franklin D. Roosevelt, Charles Lindbergh, President John F. Kennedy, actress Sarah Bernhardt, and Buffalo Bill are featured. Within these pages memorable snapshots document some famous moments in the history of the 20th century, such as when President Eisenhower decided to keep Senator Nixon on the ticket at the Ohio County Public Airport and Sen. Joseph McCarthy's famous speech about Communists in the State Department at Wheeling's McLure Hotel. However, the real stars of this book are Wheeling's own buildings, industries, and people, from machine workers on the job to millionaires at play. A chapter devoted to the African-American experience in Wheeling includes Center Market's slave auction block as well as an image of the great jazz saxophonist Leon "Chu" Berry. This collection highlights some of the horrific natural disasters that occurred at the turn of the century as well as Wheeling's Victorian architectural treasures, which were erected during the same era.
Offering unparalleled coverage of infectious diseases in children and adolescents, Feigin & Cherry's Textbook of Pediatric Infectious Diseases 8th Edition, continues to provide the information you need on epidemiology, public health, preventive medicine, clinical manifestations, diagnosis, treatment, and much more. This extensively revised edition by Drs. James Cherry, Gail J. Demmler-Harrison, Sheldon L. Kaplan, William J. Steinbach, and Peter J. Hotez, offers a brand-new full-color design, new color images, new guidelines, and new content, reflecting today's more aggressive infectious and resistant strains as well as emerging and re-emerging diseases - Discusses infectious diseases according to organ system, as well as individually by microorganisms, placing emphasis on the clinical manifestations that may be related to the organism causing the disease. - Provides detailed information regarding the best means to establish a diagnosis, explicit recommendations for therapy, and the most appropriate uses of diagnostic imaging. - Features expanded information on infections in the compromised host; immunomodulating agents and their potential use in the treatment of infectious diseases; and Ebola virus. - Contains hundreds of new color images throughout, as well as new guidelines, new resistance epidemiology, and new Global Health Milestones. - Includes new chapters on Zika virus and Guillain-Barré syndrome. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Fetal and Neonatal Physiology, edited by Drs. Polin, Fox, and Abman, focuses on physiologic developments of the fetus and newborn and their impact on the clinical practice of neonatology. A must for practice, this 4th edition brings you the latest information on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. You'll also have easy access to the complete contents and illustrations online at expertconsult.com. Gain a comprehensive, state-of-the-art understanding of normal and abnormal physiology, and its relationship to disease in the fetus and newborn premature infant, from Dr. Richard Polin and other acknowledged worldwide leaders in the field. Understand the implications of fetal and neonatal physiology through chapters devoted to clinical correlation. Apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Effectively manage the consequences of intrauterine infections with three new chapters covering intrauterine infection and preterm birth, intrauterine infection and brain injury, and intrauterine infection and chronic lung disease. Access the complete contents and illustrations online at expertconsult.com - fully searchable! Get the latest developments and a full understanding of the distinct physiology of the fetus and newborn so you can treat and manage sick newborns and preemies.
Fetal & Neonatal Physiology provides neonatologist fellows and physicians with the essential information they need to effectively diagnose, treat, and manage sick and premature infants. Fully comprehensive, this resource continues to serve as an excellent reference tool, focusing on the basic science needed for exam preparation and the key information required for full-time practice. The 5th edition is the most substantially updated and revised edition ever. In the 5 years since the last edition published, there have been thousands of publications on various aspects of development of health and disease; Fetal and Neonatal Physiology synthesizes this knowledge into definitive guidance for today's busy practitioner. Offers definitive guidance on how to effectively manage the many health problems seen in newborn and premature infants. Chapters devoted to clinical correlation help explain the implications of fetal and neonatal physiology. Allows you to apply the latest insights on genetic therapy, intrauterine infections, brain protection and neuroimaging, and much more. Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. Features a fantastic new 4-color design with 1,000 illustrations, 170+ chapters, and over 350 contributors. 16 new chapters cover such hot topics as Epigenetics; Placental Function in Intrauterine Growth Restriction; Regulation of Pulmonary Circulation; The Developing Microbiome of the Fetus and Newborn; Hereditary Contribution to Neonatal Hyperbilirubinemia; Mechanistic Aspects of Phototherapy for Neonatal Hyperbilirubinemia; Cerebellar Development; Pathophysiology of Neonatal Sepsis; Pathophysiology of Persistent Pulmonary Hypertension of the Newborn; Pathophysiology of Meconium Aspiration Syndrome; Pathophysiology of Ventilator Dependent Infants; Pathophysiology of Hypoxic-Ischemic Brain Injury; Pathophysiology of Neonatal White Matter Injury; Pathophysiology of Meningitis; Pathophysiology of Preeclampsia; and Pathophysiology of Chorioamnionitis. New Pathophysiology of Neonatal Diseases section highlights every process associated with a disease or injury, all in one place. In-depth information, combined with end-of-chapter summaries, enables deep or quick use of the text.
The most up-to-date, comprehensives single-volume guide to adult, congenital, and general cardiothoracic surgery -- from many of the foremost experts in the field Developed by authorities from leading-edge cardiothoracic surgical training programs, this much-needed reference succinctly reviews a wide-range of important topics in cardiothoracic surgery. The Johns Hopkins Manual of Cardiothoracic Surgery is especially timely given the recent development of many new scientific findings and emerging technologies. You'll find it filled with precise information on surgical techniques and pre-and postoperative strategies for managing cardiothoracic disease. In this time-saving sourcebook, you'll get an in-depth look at the full spectrum of disorders and their surgical (and medical) management options, including congenital, acquired, and neoplastic diseases. Supporting this detailed coverage is an easy-to-navigate format featuring focused tables and outline-formatted bullets, along with step-by-step explanations of the most complex operations. Features: Thorough coverage of all major areas of cardiothoracic surgery-perfect for cardiothoracic surgery fellows getting ready for Board review exams (oral and written), and cardiothoracic surgeons preparing for Board certification or recertification Skill-building perspectives on open, minimally invasive, and endovascular surgical procedures-complete with relevant surgical anatomy Indications and techniques for heart and lung transplantation Balanced, detailed presentation of both pediatric and adult patient care issues Innovative chapters on surgical ventricular remodeling, endovascular repair of thoracic aortic pathologies, correction of complex congenital defects, and thoracic oncology that reflect the most promising new surgical technologies “Key Concepts” boxes throughout focus on important “take-home” messages of chapter topics Expert authorship, with most chapters written by current or past faculty and trainees from The John Hopkins Hospital
JOHNSTONE COUNTRY. WHERE VENGEANCE IS GOLDEN. Shot in the head and left for dead, Smoke Jensen wakes up to find a bounty on his head, a target on his back, and a trigger-happy lookalike pretending to be him . . . SMOKE JENSEN: WANTED DEAD OR DEADER Reece Quaid doesn’t want to be known as “The Man Who Killed Smoke Jensen.” But when the legendary mountain man shows up in the middle of a stagecoach robbery, Quaid has no choice but to shoot him. He didn’t even know his victim was the famous Smoke Jensen—until he goes through his pockets and finds his papers. That’s when Quaid comes up with a plan. Since he resembles Smoke, he’ll simply assume his identy. Rob some banks. Hold up more stagecoaches. And shoot anyone who tries to stop him. Soon the whole world will be asking . . . Has Smoke Jensen gone bad? There’s just one problem: Smoke is still alive. Rescued by a lovely stranger and recovering from the head wound, he’s still a bit blurry about what happened—and who he even is. The only name he can come up with is that of a fictional bandit, which only adds to the confusion. Soon, the law is on the lookout for two outlaws now. But by the time Smoke comes to his senses, it may be too late. His lookalike is wanted for murder. His trail is getting bloodier every day. And Smoke is gearing up for the craziest showdown of his life—with a force of nature called Smoke Jensen . . .
Effectively manage the chronic problems of your hypertensive patients with the practical clinical tools inside Hypertension, 2nd Edition: A Companion to Braunwald’s Heart Disease. This respected cardiology reference covers everything you need to know - from epidemiology and pathophysiology through diagnosis, risk stratification, treatment, outcome studies, concomitant diseases, special populations and special situations, and future treatments. Confidently meet the needs of special populations with chronic hypertensive disease, as well as hypertension and concomitant disease. Learn new methods of aggressive patient management and disease prevention to help ensure minimal risk of further cardiovascular problems. Benefit from the authors’ Clinical Pearls to reduce complications of hypertension. Use new combination drug therapies and other forms of treatment to their greatest advantage in the management of chronic complications of hypertension. Successfully employ behavior management as a vital part of the treatment plan for hypertensives and pre-hypertensives.
Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC, Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive, dependable guidance you need to effectively diagnose and manage even the most challenging sleep disorders. Updates to genetics and circadian rhythms, occupational health, sleep in older people, memory and sleep, physical examination of the patient, comorbid insomnias, and much more keep you current on the newest areas of the field. A greater emphasis on evidence-based approaches helps you make the most well-informed clinical decisions. And, a new more user-friendly, full-color format, both in print and online, lets you find the answers you need more quickly and easily. Whether you are preparing for the new sleep medicine fellowship examination, or simply want to offer your patients today's best care, this is the one resource to use! - Make optimal use of the newest scientific discoveries and clinical approaches that are advancing the diagnosis and management of sleep disorders. - Stay on top of the hottest topics in sleep medicine with 56 new chapters, including: - Postpartum Sleep Disturbances - Fatigue Risk Management - What does Brain Imaging Reveal about Sleep Genesis and Maintenance? - Physician Examination of the Sleep Patient - Forensic Sleep Medicine - Pathophysiology and Models of Insomnia - Treatment of Insomnia: Developing Treatment Guidelines - Restrictive Lung Disorders - Sleep Medicine in the Elderly: Obstructive - Obstructive Sleep Apnea, Metabolic, and Renal Disorders - Sleep Apnea, Obesity and Bariatric Surgery - Sleep and Renal Disease - Theories of Dreaming - Why We Dream - Sleep, Stress, and Burnout - Evaluating Sleep EEG and Sleep Stage Scoring - And more - Master the newest areas in the field with 5 new sections covering: - Sleep Mechanisms and Phylogeny - Genetics of Sleep - Physiology in Sleep - Occupational Sleep Medicine - Sleep Medicine in the Elderly - Access the complete contents online, fully searchable, and follow links to abstracts for most bibliographical references. - Apply evidence-based approaches wherever available. - Find answers more easily thanks to a new user-friendly, full-color format.
Over the last six decades, there has been tremendous improvement in the survival rate for the majority of children affected by cancer in the United States and in Western Europe. Despite dramatic advances in the “developed” world, 85% of children diagnosed with cancer globally will not survive this disease. Cancer in Children and Adolescents is an accessible textbook that covers the complexities and interdisciplinary nature of cancer occurrences and provides the fundamentals of diagnosis and management of cancers that affect children and adolescents. Distinguished for its global focus, many chapters in Cancer in Children and Adolescents are co-authored by recognized specialists from around the world. Cancer in Children and Adolescents is divided into four major sections: Section 1: The Laboratory Biology and Diagnostic Evaluation of Childhood Cancer Section 2: Principles of Cancer Therapy in Children Section 3: Tumors of Children Section 4: Supportive Care
Englerin A is a guaiane sesquiterpene with potent and selective growth inhibition activity against six human renal cancer cell lines. Englerin A has captured the attention of the synthetic organic chemistry community owing to its exciting activity and its attractive polycyclic and functionalized structure. This document describes the process by which we developed a carbonyl-based synthesis of the natural product that relies upon simple, inexpensive starting materials. Utilizing a diastereoselective Michael addition reaction, followed by a remarkably selective samarium-mediated carbonyl-alkene cyclization, we completed an eight-step synthesis of englerin A.
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