Wenyi Wei's Books

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.

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Page Count

119

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3319050265

ISBN 13

9783319050263

China

Facts, Analysis, and Strategy

By: Dr. Wenyi Yu

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China

Facts, Analysis, and Strategy

By: Dr. Wenyi Yu

China’s development momentum will last for 200 more years. This book focused on China’s Economic System Reform and Opening-up to the Outside World, and answered the why, when, who, where, and how? The author used his observation and analysis to break down the Reform step by step. The story started from China’s national situation, followed by the kick-off, the operation, the policy, the little-known side of the senior decision-making process, and the organizational behaviors of the Communist Party of China. The Destiny of Chinese Nation and the development strategy are the unique achievements in China Studies. In 2009, the author presided over the program “The Planning of Economic and Cultural Industries Development of Xuanwu District, Beijing, 2009–2015.” He anticipated that the population of the Beijing metropolitan area shall be 70–100 million, and pointed out the necessity to build one more international airport in South Beijing. He also concluded the program “World Metropolis, Humanistic Beijing, and the Planning of the Cultural Finance during 2010–2015” by the same inferences. In 2014, the construction of Xiong An New District began. The Beijing Economic Circle has brought the prediction of 100-million population close to reality. On September 25, 2019, Beijing Da Xing International Airport was officially opened to traffic.

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Page Count

285

Publisher

AuthorHouse

Published Date

ISBN 10

1665529504

ISBN 13

9781665529501

Handbook for Chemical Process Research and Development, Second Edition

By: Wenyi Zhao

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Handbook for Chemical Process Research and Development, Second Edition

By: Wenyi Zhao

This fully updated second edition reflects the significant changes in process chemistry since the first edition and includes more common process issues such as safety, cost, robustness, and environmental impact. Some areas have made notable progress such as process safety, stereochemistry, new reagents and reagent surrogates. Forty years ago there were few process research and development activities in the pharmaceutical industry, partly due to the simplicity of drug molecules. With increasing structural complexity especially the introduction of chiral centers into drug molecules and stricter regulations, process R&D has become one of the critical departments for pharmaceutical companies. Features: This unique volume now in its second edition is designed to provide readers with an unprecedented strategy and approach which will help chemists and graduate students develop chemical processes in an efficient manner. Promotes an industrial mindset concerning safety and commercial viability when developing methods. The author discusses development strategies with case studies and experimental procedures. Focuses on mechanism-guided process development which provides readers with practical strategies and approaches. Addresses more common process issues such as safety, cost, robustness, and environmental impact. This book provides a new direction for scientists, researchers, and students in materials science and polymer chemistry who seek to better understand the chemistry behind conducting polymers and improve their performance for use in advanced energy applications.

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Page Count

938

Publisher

CRC Press

Published Date

ISBN 10

1000859053

ISBN 13

9781000859058

Handbook for Chemical Process Research and Development

By: Wenyi Zhao

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Handbook for Chemical Process Research and Development

By: Wenyi Zhao

The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

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Page Count

864

Publisher

CRC Press

Published Date

ISBN 10

1315350203

ISBN 13

9781315350202

Unconstrained Face Recognition

By: Shaohua Kevin Zhou,Rama Chellappa,Wenyi Zhao

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Unconstrained Face Recognition

By: Shaohua Kevin Zhou,Rama Chellappa,Wenyi Zhao

Face recognition has been actively studied over the past decade and continues to be a big research challenge. Just recently, researchers have begun to investigate face recognition under unconstrained conditions. Unconstrained Face Recognition provides a comprehensive review of this biometric, especially face recognition from video, assembling a collection of novel approaches that are able to recognize human faces under various unconstrained situations. The underlying basis of these approaches is that, unlike conventional face recognition algorithms, they exploit the inherent characteristics of the unconstrained situation and thus improve the recognition performance when compared with conventional algorithms. Unconstrained Face Recognition is structured to meet the needs of a professional audience of researchers and practitioners in industry. This volume is also suitable for advanced-level students in computer science.

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Page Count

244

Publisher

Springer Science & Business Media

Published Date

ISBN 10

0387294864

ISBN 13

9780387294865

Adaptive Interference Mitigation in GNSS

By: Renbiao Wu,Wenyi Wang,Dan Lu,Lu Wang,Qiongqiong Jia

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Adaptive Interference Mitigation in GNSS

By: Renbiao Wu,Wenyi Wang,Dan Lu,Lu Wang,Qiongqiong Jia

This book introduces readers to adaptive interference mitigation techniques based on multiple antennas for global navigation satellite systems (GNSS) in the time, domain, spatial and spatial-temporal domains. As the performance of GNSS can easily be impacted by various intentional and unintentional interferences, the book explores in detail various types of interference, including jamming , high dynamic jamming, spoofing, multipath and pulsed interference. It offers a valuable reference work for graduate students and engineers in the field of satellite navigation and signal processing.

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Page Count

289

Publisher

Springer

Published Date

ISBN 10

9811055718

ISBN 13

9789811055713

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

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SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

By: Hiroyuki Inuzuka,Wenyi Wei

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Solve jigsaw puzzle

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Page Count

119

Publisher

Springer Science & Business Media

Published Date

ISBN 10

3319050265

ISBN 13

9783319050263

Book's by Wenyi Wei

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

China

China

Handbook for Chemical Process Research and Development, Second Edition

Handbook for Chemical Process Research and Development, Second Edition

Handbook for Chemical Process Research and Development

Handbook for Chemical Process Research and Development

Unconstrained Face Recognition

Unconstrained Face Recognition

Adaptive Interference Mitigation in GNSS

Adaptive Interference Mitigation in GNSS

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

SCF and APC E3 Ubiquitin Ligases in Tumorigenesis

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