Cell Signaling presents the principles and components that underlie all known signaling processes. It provides undergraduate and graduate students the conceptual tools needed to make sense of the dizzying array of pathways used by the cell to communicate. By emphasizing the common design principles, components, and logic that drives all signa
Cell Signaling provides undergraduate and graduate students with the conceptual tools needed to make sense of the dizzying array of pathways that cells use to detect, process, and respond to signals from the environment. By emphasizing the common design principles and molecular processes that underlie all signaling mechanisms, the book develops a broad conceptual framework through which students can understand diverse signaling pathways and networks. The book first examines the common currencies of cellular information processing and the core components of the signaling machinery. It then shows how these individual components link together into networks and pathways to perform more sophisticated tasks. Many specific examples are provided throughout to illustrate common principles, and to provide a comprehensive overview of major signaling pathways. Thoroughly revised, this second edition includes two new chapters and substantial updates to the text and figures throughout the book. Key features: The book provides a conceptual framework through which all signaling pathways can be understood without memorization of details It is extensively illustrated, including high-quality diagrams and schematics to elucidate important concepts and processes Each chapter concludes with a useful summary section that brings together the key concepts End-of-chapter review questions test the reader’s understanding of the material covered Two new chapters have been written especially for this edition: "Signaling and Disease" and "Diversity in Signaling across Phylogeny
This book is an introduction to optimal stochastic control for continuous time Markov processes and the theory of viscosity solutions. It covers dynamic programming for deterministic optimal control problems, as well as to the corresponding theory of viscosity solutions. New chapters in this second edition introduce the role of stochastic optimal control in portfolio optimization and in pricing derivatives in incomplete markets and two-controller, zero-sum differential games.
Dieser Band fasst systematisch alle Begriffe und Konzepte zusammen, die das Fundament der Atom- und Molekülforschung, Optik und Technik bilden: Atome, zweiatomige Moleküle, Atome und Moleküle in statischen und elektromagnetischen Feldern, nichtlineare Optik. Physikalische und mathematische Definitionen, ausführliche Tabellen und ein Überblick über die Tensoralgebra wurden der besseren Lesbarkeit des Haupttextes halber in umfangreiche Anhänge ausgelagert. Jedes Kapitel schließt mit Übungsaufgaben und Angaben zur weiterführenden Literatur ab.
This new edition, like the first, presents a thorough introduction to differential and integral calculus, including the integration of differential forms on manifolds. However, an additional chapter on elementary topology makes the book more complete as an advanced calculus text, and sections have been added introducing physical applications in thermodynamics, fluid dynamics, and classical rigid body mechanics.
Theory of Unimolecular Reactions provides a comprehensive analysis of the theory of unimolecular reactions, also known to kineticists as the Rice-Marcus or the Rice-Ramsperger-Kassel-Marcus theory, and to those working in mass spectrometry and related fields as the quasi-equilibrium theory or the theory of mass spectra. This book demonstrates how theoretical parameters are related to experimental observables and describes the methods that are used to obtain useful numerical answers. This monograph consists of 11 chapters and begins by explaining the derivation of the expression for the basic rate k(E), with emphasis on the unimolecular rate constant, intramolecular energy transfer, and potential energy surfaces in unimolecular reactions. The statistical calculation of unimolecular rate under vibrational potential is also given, along with pertinent degrees of freedom. The remaining chapters explore the energy distribution functions appropriate to each system, the averaging of k(E), and the relations between theoretical and experimental parameters. Thermal reactions, chemical activation systems, and the theory of mass spectra are examined. The last chapter is devoted to the transition state and its ambiguities. This text will be of interest to gas kineticists, mass spectrometrists, and students and researchers working in the field of physical chemistry.
This book develops the subject of nonlinear plasma physics from a general physics perspective. It begins with a description of nonlinear oscillations, the parametric instability, the pendulum, and the nonlinear island overlap criterion. The Kolomogorov-Arnold-Moser (KAM) theory is analyzed. Laboratory visualizations of the KAM theory are presented for experiments in toroidal plasma confinement and rotating fluids. The subjects of transport in E x B flows and geostrophic flows are developed in parallel, stressing the generality of the Charney-Hasegawa-Mima equation. The dual nature of wave turbulence and vortex dynamics is developed for plasmas and geophysical flows. The presentation of the subject of nonlinear maps shows how maps are related to the nonlinear dynamics in plasma physics problems. Numerous space plasma and fusion physics examples are developed throughout the book. The final chapter deals with turbulence theory, renormalized mode coupling equations, and Kolomogorov-type spectra as modified for anisotropic plasmas.
This book may be regarded as consisting of two parts. In Chapters I-IV we pre sent what we regard as essential topics in an introduction to deterministic optimal control theory. This material has been used by the authors for one semester graduate-level courses at Brown University and the University of Kentucky. The simplest problem in calculus of variations is taken as the point of departure, in Chapter I. Chapters II, III, and IV deal with necessary conditions for an opti mum, existence and regularity theorems for optimal controls, and the method of dynamic programming. The beginning reader may find it useful first to learn the main results, corollaries, and examples. These tend to be found in the earlier parts of each chapter. We have deliberately postponed some difficult technical proofs to later parts of these chapters. In the second part of the book we give an introduction to stochastic optimal control for Markov diffusion processes. Our treatment follows the dynamic pro gramming method, and depends on the intimate relationship between second order partial differential equations of parabolic type and stochastic differential equations. This relationship is reviewed in Chapter V, which may be read inde pendently of Chapters I-IV. Chapter VI is based to a considerable extent on the authors' work in stochastic control since 1961. It also includes two other topics important for applications, namely, the solution to the stochastic linear regulator and the separation principle.
This textbook covers the basics necessary for understanding the statistical theory of unimolecular reactions in its original and variational, phase-space and angular momentum-conserved incarnations. Because the emphasis is on "why" rather than "how to", there are many problems and answers to explore further. The book is targeted at graduate and advanced undergraduate students studying chemical dynamics, chemical kinetics and theoretical chemistry.
The early Supreme Court justices wrestled with how much press and speech is protected by freedoms of press and speech, before and under the First Amendment, and with whether the Sedition Act of 1798 violated those freedoms. This book discusses the twelve Supreme Court justices before John Marshall, their views of liberties of press and speech, and the Sedition Act prosecutions over which some of them presided. The book begins with the views of the pre-Marshall justices about freedoms of press and speech, before the struggle over the Sedition Act. It finds that their understanding was strikingly more expansive than the narrow definition of Sir William Blackstone, which is usually assumed to have dominated the period. Not one justice of the Supreme Court adopted that narrow definition before 1798, and all expressed strong commitments to those freedoms. The book then discusses the views of the early Supreme Court justices about freedoms of press and speech during the national controversy over the Sedition Act of 1798 and its constitutionality. It finds that, though several of the justices presided over Sedition Act trials, the early justices divided almost evenly over that issue with an unrecognized half opposing its constitutionality, rather than unanimously supporting the Act as is generally assumed. The book similarly reassesses the Federalist party itself, and finds that an unrecognized minority also challenged the constitutionality of the Sedition Act and the narrow Blackstone approach during 1798-1801, and that an unrecognized minority of the other states did as well in considering the Virginia and Kentucky Resolutions. The book summarizes the recognized fourteen prosecutions of newspaper editors and other opposition members under the Sedition Act of 1798. It sheds new light on the recognized cases by identifying and confirming twenty-two additional Sedition Act prosecutions. At each of these steps, this book challenges conventional views in existing histories of the early republic and of the early Supreme Court justices.
Kids ask the darndest questions—and the answers make for a “funny and fascinating”(Publishers Weekly) book. Wendell Jamieson’s son, Dean, has always had a penchant for asking odd questions. “Dad, what would hurt more—getting run over by a car, or getting stung by a jellyfish?” “Dad, why do policemen like donuts?” “Dad, does Mona Lisa wear shoes?” Because Dad is a newspaperman and city editor for The New York Times, he decided to seek out the real answers to Dean’s questions from top experts—movie directors and ship captains, brain surgeons and stabbing victims, a Buddhist monk and a bra fitter, and even Yoko Ono. Their father-son journey for answers to the tough—and weird—questions of life is a sometimes surprising, often hilarious, and always fascinating celebration of the value and beauty of childlike curiosity. Watch a QuickTime trailer for this book.
The placid life of retired professor David Neal is turned upside down when Lu, his wife of fifty years, is felled by a stroke and lies in an irreversible coma. David is presented with the terrible dilemma that could happen to any of us. Should he order his beloved Lu’s respirator turned off, ending her hopeless life? After a tortured inner struggle, David overcomes his doubts. But the doctors are blocked by David and Lu’s determined daughter, a federal judge, who will not consent to the “murder” of her mother. In a dramatic bedside scene David defiantly ends Lu’s life himself. The ambitious prosecutor with an eye on the governorship charges David with murder. David is represented without fee by a wizened attorney whose own wife suffered from an incurable disease. The headline-grabbing trial explores the moral, legal and psychological issues of mercy killing. Readers will not be able to stop turning the pages as one unexpected development after another leads to a surprising ending. Wendell B. Will, an experienced trial attorney, shows us first hand the maneuvering within the judge’s chambers, the fast moving drama of the trial and the tumult of the jury deliberations.
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