Particle accelerators are a major invention of the 20th century. In the last eight decades, they have evolved enormously and have fundamentally changed the way we live, think and work.Accelerators are the most powerful microscopes for viewing the tiniest inner structure of cells, genes, molecules, atoms and their constituents such as protons, neutrons, electrons, neutrinos and quarks. This opens up a whole new world for materials science, chemistry and molecular biology. Accelerators with megawatt beam power may ultimately solve a critical problem faced by our society, namely, the treatment of nuclear waste and the supply of an alternative type of energy.There are also tens of thousands of small accelerators all over the world. They are used every day for medical imaging, cancer therapy, radioisotope production, high-density chip-making, mass spectrometry, cargo x-ray/gamma-ray imaging, detection of explosives and illicit drugs, and weapons. This volume provides a comprehensive review of this driving and fascinating field.The poster (also available in 1118 x 406 mm size) which illustrates the history and development of particle accelerators from 1919 to the future can be purchased separately
The theme of this volume, ?Medical Applications of Accelerators?, is of enormous importance to human health and has a deep impact on our society.The invention of particle accelerators in the early 20th century created a whole new world for producing energetic X-rays, electrons, protons, neutrons and other particle beams. Immediately these beams found revolutionary applications in medicine. There are two important yet distinct medical applications. On the one hand, accelerators produce radioisotopes for various nuclear medicines for millions of patients each year, and on the other hand, they also produce particle beams for radiation therapy for the treatment of cancer. The particle beams can be X-rays (generated by high-energy electrons), protons, neutrons or heavy ions such as carbon. Today there are more than 5,000 accelerators routinely used in hospitals all over the world for nuclear medicine and cancer therapy. The great potential of accelerator applications in medicine can hardly be exaggerated.This volume contains 14 articles, all written by distinguished scholars.
Over the last half century we have witnessed tremendous progress in the production of high-quality photons by electrons in accelerators. This dramatic evolution has seen four generations of accelerators as photon sources. The 1st generation used the electron storage rings built primarily for high-energy physics experiments, and the synchrotron radiation from the bending magnets was used parasitically. The 2nd generation involved rings dedicated to synchrotron radiation applications, with the radiation again from the bending magnets. The 3rd generation, currently the workhorse of these photon sources, is dedicated advanced storage rings that employ not only bending magnets but also insertion devices (wigglers and undulators) as the source of the radiation. The 4th generation, which is now entering operation, is photon sources based on the free electron laser (FEL), an invention made in the early 1970s. Each generation yielded growths in brightness and time resolution that were unimaginable just a few years earlier. In particular, the progression from the 3rd to 4th generation is a true revolution; the peak brilliance of coherent soft and hard x-rays has increased by 7-10 orders of magnitude, and the image resolution has reached the angstrom (1 = 10-10 meters) and femto-second (1 fs = 10-15 second) scales. These impressive capabilities have fostered fundamental scientific advances and led to an explosion of numerous possibilities in many important research areas including material science, chemistry, molecular biology and the life sciences. Even more remarkably, this field of photon source invention and development shows no signs of slowing down. Studies have already been started on the next generation of x-ray sources, which would have a time resolution in the atto-second (1 as = 10-18 second) regime, comparable to the time of electron motion inside atoms. It can be fully expected that these photon sources will stand out among the most powerful future science research tools. The physics community as well as the entire scientific community will hear of many pioneering and groundbreaking research results using these sources in the coming years. This volume contains fifteen articles, all written by leading scientists in their respective fields. It is aimed at the designers, builders and users of accelerator-based photon sources as well as general audience who are interested in this topic.
Physical and biological basis of proton and of carbon ion radiation therapy and clinical outcome data / Herman Suit, Thomas F. Delaney and Alexei Trofimov -- The production of radionuclides for radiotracers in nuclear medicine / Thomas J. Ruth -- Proton radiation therapy in the hospital environment : conception, development, and operation of the initial hospital-based facility / James M. Slater, Jerry D. Slater and Andrew J. Wroe -- Microwave electron linacs for oncology / David H. Whittum -- Heavy-particle radiotherapy : system design and application / H. Tsujii, S. Minohara and K. Noda -- High frequency linacs for hadrontherapy / Ugo Amaldi, Saverio Braccini and Paolo Puggioni -- Medical cyclotrons / D.L. Friesel and T.A. Antaya -- Synchrotrons for hadrontherapy / Marco G. Pullia -- Beam delivery systems for particle radiation therapy : current status and recent developments / J.M. Schippers -- Laser acceleration of ions for radiation therapy / Toshiki Tajima, Dietrich Habs and Xueqing Yan -- FFAGs as accelerators and beam delivery devices for ion cancer therapy / Dejan Trbojevic -- The dielectric wall accelerator / George J. Caporaso, Yu-Jiuan Chen and Stephen E. Sampayan -- The supercollider : the Texas days - a personal recollection of its short life and demise / Stanley Wojcicki -- A man for all seasons : Robert R. Wilson / Edwin L. Goldwasser
Each generation yielded growths in brightness and time resolution that were unimaginable just a few years earlier. In particular, the progression from the 3rd to 4th generation is a true revolution; the peak brilliance of coherent soft and hard x-rays has increased by 7-10 orders of magnitude, and the image resolution has reached the angstrom (1 [symbol] = 10-10 meters) and femto-second (1 fs = 10-15 second) scales. These impressive capabilities have fostered fundamental scientific advances and led to an explosion of numerous possibilities in many important research areas including material science, chemistry, molecular biology and the life sciences. Even more remarkably, this field of photon source invention and development shows no signs of slowing down. Studies have already been started on the next generation of x-ray sources, which would have a time resolution in the atto-second (1 as = 10-18 second) regime, comparable to the time of electron motion inside atoms.
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