Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures. This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society. Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research. Hallmark features: Up-to-the-minute information in drug research Vignettes of special and unusual information, and anecdotes Discusses drug prototypes from all sources More comprehensive than other volumes on history of drug discovery From the reviews: "...an excellent bibliographic resource for those interested in the background papers that serve as the foundation for discovery of specific drug entities." JOURNAL OF MEDICAL CHEMISTRY, June 2006 "...a very comprehensive overview of drug development. It should be on the shelf on any aspiring pharmacist, medicinal chemist, or person interested in the history of therapeutic agents." JOURNAL OF CHEMICAL EDUCATION, February 2006 "...a very readable and closely researched book..." CHEMISTRY & INDUSTRY, October 2005
The history of medicinal drugs extends back to the earliest human civilizations, when the search began for natural materialsplant, animal, or mineralthat might possess the power to cure, alleviate, or avert maladies or wounds. The quest continues still, conducted now by scientists and doctors in the thousands and in the shadow of big pharma. The story abounds with human interest, populated as it is with geniuses and charlatans, with the inspired and the deluded, with self-sacrifice and self-aggrandizement. Medicine over the centuries has been pervaded by false doctrines amounting to superstitions, the causes of endless misery and numberless death, and there were truths not recognized for decades and longer. Finally, industry, and its profit motive, has become an inescapable presence, which is sometimes a blessing to some or a curse to others, a source sometimes of corruption or sometimes of dazzling progress. Which of these predominates, it is up to the reader to judge.
Managing the Drug Discovery Process: How to Make It More Efficient and Cost-Effective thoroughly examines the current state of pharmaceutical research and development by providing chemistry-based perspectives on biomedical research, drug hunting and innovation. The book also considers the interplay of stakeholders, consumers, and the drug firm with attendant factors, including those that are technical, legal, economic, demographic, political, social, ecological, and infrastructural. Since drug research can be a high-risk, high-payoff industry, it is important to researchers to effectively and strategically manage the drug discovery process. This book takes a closer look at increasing pre-approval costs for new drugs and examines not only why these increases occur, but also how they can be overcome to ensure a robust pharmacoeconomic future. Written in an engaging manner and including memorable insights, this book is aimed at redirecting the drug discovery process to make it more efficient and cost-effective in order to achieve the goal of saving countless more lives through science. A valuable and compelling resource, this is a must-read for all students and researchers in academia and the pharmaceutical industry. - Considers drug discovery in multiple R&D venues, including big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable
A collection of fascinating stories, entertainingly told, revealing the human face of science. Eurekas and Euphorias encompasses some 200 anecdotes brilliantly illustrating scientists in all their shapes: the obsessive and the dilettantish, the genial, the envious, the preternaturally brilliant and the slow-witted who sometimes see further in the end, the open-minded and the intolerant, recluses and arrivistes. Told with wit and relish by Walter Gratzer, here are stories to delight, astonish, instruct, and most especially, entertain the general reader, scientist and non-scientist alike.
Organized by body system and ailment makes it easy to locate appropriate therapies. Includes background on the physiology of major systems and ailments so readers can understand how and why a pharmaceutical, botanical, or dietary supplement works. Broad coverage includes green plants, fungi, and microorganisms. Includes extensive references and citations from both conventional and complimentary-alternative medical systems when natural products or their derivatives are involved.
This indispensable work analyzes approximately 150 pharmaceuticals, revealing the key prototype drugs from which all medicinal compounds currently used are derived. A unique "tree and branch" format indicates areas of possible future development as well as areas of neglect.
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