How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design Considers trial design from both an academic and industry perspective Includes a structured library of available phase II trial designs Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.
Now superintendents can turn board meetings into productive, results-getting events that help them focus on teaching and learning to achieve district goals.
Growth Regulation and Carcinogenesis discusses topics such as growth factors, including stimulators and inhibitors of proliferation; networks in proliferation regulation; differentiation-inducing factors; origins of neoplasia and their relationship to growth control; genetic alterations in cellular regulatory machinery; extrachromosomal phenomena; non-genotoxic carcinogens; immortalization and transformation of cells; and the role of cell production, cell function, and cell elimination in physiological growth control.
Although they are relative latecomers on the evolutionary scene, having emerged only 135?170 million years ago, angiosperms—or flowering plants—are the most diverse and species-rich group of seed-producing land plants, comprising more than 15,000 genera and over 350,000 species. Not only are they a model group for studying the patterns and processes of evolutionary diversification, they also play major roles in our economy, diet, and courtship rituals, producing our fruits, legumes, and grains, not to mention the flowers in our Valentine’s bouquets. They are also crucial ecologically, dominating most terrestrial and some aquatic landscapes. This fully revised edition of Phylogeny and Evolution of the Angiosperms provides an up-to-date, comprehensive overview of the evolution of and relationships among these vital plants. Incorporating molecular phylogenetics with morphological, chemical, developmental, and paleobotanical data, as well as presenting a more detailed account of early angiosperm fossils and important fossil information for each evolutionary branch of the angiosperms, the new edition integrates fossil evidence into a robust phylogenetic framework. Featuring a wealth of new color images, this highly synthetic work further reevaluates long-held evolutionary hypotheses related to flowering plants and will be an essential reference for botanists, plant systematists, and evolutionary biologists alike.
Mathematics for the Environment shows how to employ simple mathematical tools, such as arithmetic, to uncover fundamental conflicts between the logic of human civilization and the logic of Nature. These tools can then be used to understand and effectively deal with economic, environmental, and social issues. With elementary mathematics, the book se
This Luke commentary bundle features volumes from the NIV Application Commentary Series, Zondervan Exegetical Commentary Series, and Expositor's Bible Commentary Series authored by Darrell L. Bock, David E. Garland, Walter L. Liefeld, and David W. Pao. The diverse features from each of the volumes gives you all the tools you need to master the book of Luke.
As we begin a new millennium, humankind is still plagued by intergroup conflict, racism, prejudice, stereotyping, and discrimination. This book is intended both as supplemental reading for courses and as a practical guidebook for individuals and programs interested in reducing prejudice and improving intergroup relations. It provides the only comprehensive review and compilation of techniques of improving intergroup relations. There′s a huge amount of literature on the causes and nature of prejudice, reflecting great interest in the topic, but the literature on prejudice reduction is more scattered, spread across a range of theoretical and applied sources. This book brings these literatures together, with an emphasis on helping to elucidate what works and why.
This intriguing book was born out of the many discussions the authors had in the past 10 years about the role of scale-free structure and dynamics in producing intelligent behavior in brains. The microscopic dynamics of neural networks is well described by the prevailing paradigm based in a narrow interpretation of the neuron doctrine. This book broadens the doctrine by incorporating the dynamics of neural fields, as first revealed by modeling with differential equations (K-sets). The book broadens that approach by application of random graph theory (neuropercolation). The book concludes with diverse commentaries that exemplify the wide range of mathematical/conceptual approaches to neural fields. This book is intended for researchers, postdocs, and graduate students, who see the limitations of network theory and seek a beachhead from which to embark on mesoscopic and macroscopic neurodynamics.
This informative publication presents the broad application of nuclear magnetic resonance to many of today's problem areas in agriculture. Solid-state NMR methodology is covered, with its applications to the study of intact agricultural matrices such as plant cell walls, photosynthetic chloroplast membranes, forages, wood cellulose, and soils. In vivo solution NMR methodology and its applications to the study of different functioning plant tissues and their biochemical responses to various pathological, physiological, and toxicological stresses are illustrated with examples using 31P, 13C, 23Na, and 15N resonance methods. An introductory chapter presents a review of the in vivo literature and some basic principles and requirements for carrying out such experiments. A special section focuses on state-of-the-art 13C and 1H high-resolution multidimensional methods and their application to the study of agricultural toxins; biologically active components, including their structures and biosyntheses, and dynamic measurements of relaxation phenomena associated with cross relaxation in water bound to food proteins.
The now–staunchly red state of Texas was deep blue in 1950 and had virtually no functioning Republican Party. California, on the other hand, was reliably red. Today, both states have jumped to the opposite end of the political spectrum. Texas is one of the most conservative states, while California has become one of today’s most liberal bastions. These are the most dramatic cases, but notable shifts in voting patterns have occurred throughout the western states in recent decades—shifts so varied and complex that they have, until now, eluded the attention focused on the drastic examples of the South and Northeast. Bringing clarity to the remarkably mixed yet poorly understood map of America’s red, blue, and purple western half, Color Coded presents the first comprehensive history of political change and stability in the region between 1950 and 2016. The West, in Walter Nugent’s analysis, includes nineteen states: the thirteen that the U.S. Census Bureau calls the Western Region—roughly from the Rocky Mountains to the Pacific, as well as off-shore Alaska and Hawaii—plus the six Great Plains states from North Dakota south to Texas. Consulting official voting results of more than 5,300 state and national elections, as well as newspaper reports, oral histories, public documents, and other sources, Nugent reveals the ever-shifting patterns that have defined western politics in modern times. Geography, culture, history, political trajectories, and the charisma of key political actors have all played their part in these changes—and will, Nugent asserts, continue to do so for the foreseeable future. A powerful, exhaustively researched study of modern political organization, party development, and shifting voter blocs in the West, Color Coded deftly charts, as well, the profound red-blue tensions that have defined modern America. Returns for the 5,300-plus elections on which the book is based, covering the nineteen western states between 1950 and 2016, are compiled in the book's appendix.
For a comprehensive understanding of human physiology — from molecules to systems —turn to the latest edition of Medical Physiology. This updated textbook is known for its unparalleled depth of information, equipping students with a solid foundation for a future in medicine and healthcare, and providing clinical and research professionals with a reliable go-to reference. Complex concepts are presented in a clear, concise, and logically organized format to further facilitate understanding and retention. - Clear, didactic illustrations visually present processes in a clear, concise manner that is easy to understand. - Intuitive organization and consistent writing style facilitates navigation and comprehension. - Takes a strong molecular and cellular approach that relates these concepts to human physiology and disease. - Student Consult eBook version included with purchase. This enhanced eBook experience includes access -- on a variety of devices -- to the complete text with thorough hyperlinking, images, 10 animations, and copious linkout notes prepared by the Editors. - An increased number of clinical correlations provides a better understanding of the practical applications of physiology in medicine. - Highlights new breakthroughs in molecular and cellular processes, such as the role of epigenetics, necroptosis, and ion channels in physiologic processes, to give insights into human development, growth, and disease. - Several new authors offer fresh perspectives in many key sections of the text, and meticulous editing makes this multi-authored resource read with one unified voice.
With your heavy case load, you can't afford to waste time searching for answers. Cardiology, 3rd Edition, by Drs. Crawford, DiMarco, and Paulus, offers you just the practical, problem-based guidance you need to quickly overcome any clinical challenge. 8 color-coded sections cover the 8 major clinical syndromes of cardiovascular disease—each section a virtual "mini textbook" on its topic! 40 new chapters keep you up to date with the latest advances in the field, while more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs capture clinical manifestations as they present in practice. It’s current, actionable information that you can put to work immediately for your patients! Offers a problem-based approach that integrates basic science, diagnostic investigations, and therapeutic management in one place for each cardiovascular disease so you can quickly find all of the actionable knowledge you need without flipping from one section to another. Features introductory bulleted highlights in each chapter that present the most pertinent information at a glance. Presents abundant algorithms to expedite clinical decision making. Includes more than 2,000 lavish, high-quality illustrations, color photographs, tables, and ECGs that capture clinical manifestations as they present in practice, and promote readability and retention. Includes 40 new chapters including Inherited Arrhythmia Syndromes, Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy in CHD, Management of the Cyanotic Patient with CHD, Special Problems for the Cardiology Consultant Dealing with Bariatric/Gastric Bypass — and many more — that equip you with all of the latest knowledge. Presents "Special Problem" sections—many new to this edition—that provide practical advice on problems that can be difficult to treat.
From the development of each vaccine to its use in reducing disease, Plotkin's Vaccines, 7th Edition, provides the expert information you need to provide optimal care to your patients. This award-winning text offers a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues – plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine. - Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines. - Features a new chapter on maternal immunization. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
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