In the immediate aftermath of World War II, the United States Army became the principal agent of American foreign policy. The army designed, implemented, and administered the occupations of the defeated Axis powers Germany and Japan, as well as many other nations. Generals such as Lucius Clay in Germany, Douglas MacArthur in Japan, Mark Clark in Austria, and John Hodge in Korea presided over these territories as proconsuls. At the beginning of the Cold War, more than 300 million people lived under some form of U.S. military authority. The army's influence on nation-building at the time was profound, but most scholarship on foreign policy during this period concentrates on diplomacy at the highest levels of civilian government rather than the armed forces' governance at the local level. In Army Diplomacy, Hudson explains how U.S. Army policies in the occupied nations represented the culmination of more than a century of military doctrine. Focusing on Germany, Austria, and Korea, Hudson's analysis reveals that while the post–World War II American occupations are often remembered as overwhelming successes, the actual results were mixed. His study draws on military sociology and institutional analysis as well as international relations theory to demonstrate how "bottom-up" decisions not only inform but also create higher-level policy. As the debate over post-conflict occupations continues, this fascinating work offers a valuable perspective on an important yet underexplored facet of Cold War history.
The core of this three-volume book deals with damage-associated molecular patterns abbreviated “DAMPs”, which are unique molecules that save life and fight for survival of all organisms on this planet by triggering robust inflammatory/immune defense responses upon any injury, including those caused by pathogens such as viruses and bacteria. However, these molecules also have a dark side: when produced in excess upon severe insults, they can trigger serious human diseases. The three volumes present current understanding of the importance of DAMP-promoted immune responses in the etiopathogenesis of human diseases and explore how this understanding is impacting diagnosis, prognosis, and future treatment. This third volume addresses the potential of DAMPs in clinical practice, as therapeutic targets and therapeutics, by focusing on a description of antigen-related diseases, which are pathogenetically dominated by DAMPs, that is, infectious and autoimmune disorders and allograft rejection (as an undesired function of these molecules), as well as tumor rejection (as the desired function of these molecules). The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses; Damage-Associated Molecular Patterns in Human Diseases - Vol. 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets.
This is a chronicle of South Carolina describing in human terms 475 years of recorded history in the Palmetto State. Recounting the period from the first Spanish exploration to the end of the Civil War, the author charts South Carolina's rising national and international importance.
While religious diversity is often considered a recent phenomenon in America, the Cape Fear region of southeastern North Carolina has been a diverse community since the area was first settled. Early on, the region and the port city of Wilmington were more urban than the rest of the state and thus provided people with opportunities seldom found in other parts of North Carolina. This area drew residents from many ethnic backgrounds, and the men and women who settled there became an integral part of the region’s culture. Set against the backdrop of national and southern religious experience, A Coat of Many Colors examines issues of religious diversity and regional identity in the Cape Fear area. Author Walter H. Conser Jr. draws on a broad range of sources, including congregational records, sermon texts, liturgy, newspaper accounts, family memoirs, and technological developments to explore the evolution of religious life in this area. Beginning with the story of prehistoric Native Americans and continuing through an examination of life at the end of twentieth century, Conser tracks the development of the various religions, denominations, and ethnic groups that call the Cape Fear region home. From early Native American traditions to the establishment of the first churches, cathedrals, synagogues, mosques, and temples, A Coat of Many Colors offers a comprehensive view of the religious and ethnic diversity that have characterized Cape Fear throughout its history. Through the lens of regional history, Conser explores how this area’s rich religious and racial diversity can be seen as a microcosm for the South, and he examines the ways in which religion can affect such diverse aspects of life as architecture and race relations.
Walter Blair was the literary scholar who almost single-handedly gave the study of American humor significance in the academic world. By categorizing the writings of American literary humorists into such diverse styles as the Old Southwest, Local Color, and Literary Comedian humor -- each having serious social import--Blair abolished the notion that they were all practicing the same kind of intellectual irreverence. Moving through more than six decades of Walter Blair's works, Essays on American Humor: Blair through the Ages provides a comprehensive introduction to the discipline he developed. Hamlin Hill has selected and ordered this collection to show the scope of Blair's expertise, which encompasses the careers of tall-tale characters like Baron Munchausen as well as the achievements of such real-life humorists as E. B. White. The pieces range in time from Blair's introduction to the 1928 edition of Julia A. Moore's poetry to his 1989 introduction to a work commemorating Davy Crockett's two-hundredth anniversary. Historical and biographical essays, source-and-influence studies, and analyses of texts constitute the bulk of the book. An entire section is devoted to discourses on Mark Twain, Blair's major subject.
Managing the Drug Discovery Process, Second Edition thoroughly examines the current state of pharmaceutical research and development by providing experienced perspectives on biomedical research, drug hunting and innovation, including the requisite educational paths that enable students to chart a career path in this field. The book also considers the interplay of stakeholders, consumers, and drug firms with respect to a myriad of factors. Since drug research can be a high-risk, high-payoff industry, it is important to students and researchers to understand how to effectively and strategically manage both their careers and the drug discovery process. This new edition takes a closer look at the challenges and opportunities for new medicines and examines not only the current research milieu that will deliver novel therapies, but also how the latest discoveries can be deployed to ensure a robust healthcare and pharmacoeconomic future. All chapters have been revised and expanded with new discussions on remarkable advances including CRISPR and the latest gene therapies, RNA-based technologies being deployed as vaccines as well as therapeutics, checkpoint inhibitors and CAR-T approaches that cure cancer, diagnostics and medical devices, entrepreneurship, and AI. Written in an engaging manner and including memorable insights, this book is aimed at anyone interested in helping to save countless more lives through science. A valuable and compelling resource, this is a must-read for all students, educators, practitioners, and researchers at large—indeed, anyone who touches this critical sphere of global impact—in and around academia and the biotechnology/pharmaceutical industry. - Considers drug discovery in multiple R&D venues - big pharma, large biotech, start-up ventures, academia, and nonprofit research institutes - with a clear description of the degrees and training that will prepare students well for a career in this arena - Analyzes the organization of pharmaceutical R&D, taking into account human resources considerations like recruitment and configuration, management of discovery and development processes, and the coordination of internal research within, and beyond, the organization, including outsourced work - Presents a consistent, well-connected, and logical dialogue that readers will find both comprehensive and approachable - Addresses new areas such as CRISPR gene editing technologies and RNA-based drugs and vaccines, personalized medicine and ethical and moral issues, AI/machine learning and other in silico approaches, as well as completely updating all chapters
Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.
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