Abusive Endings offers a thorough analysis of the social-science literature on one of the most significant threats to the health and well-being of women today—abuse at the hands of their male partners. The authors provide a moving description of why and how men abuse women in myriad ways during and after a separation or divorce. The material is punctuated with the stories and voices of both perpetrators and survivors of abuse, as told to the authors over many years of fieldwork. Written in a highly readable fashion, this book will be a useful resource for researchers, practitioners, activists, and policy makers.
This book-Behrendt's principle theoretical work in German and the precursor to Modern Building- presents a revisionist concept of style that places equal emphasis on form and function. Now available in English for the first time, this incisive treatise boldly advocates international modernism to the general public.
Steroidogenesis begins with internalization of low-density lipoprotein particles and subsequent intracellular processing of cholesterol. Disorders in these steps include adrenoleukodystrophy, Wolman disease, and Niemann–Pick type C disease, which may present as adrenal insufficiency. Cholesterol delivery to the inner mitochondrial membrane is regulated by the steroidogenic acute regulatory protein, StAR, and cholesterol is converted to pregnenolone within mitochondria by the cholesterol side chain cleavage enzyme, P450scc. Severe StAR mutations cause classic congenital lipoid adrenal hyperplasia (CAH), characterized by adrenal insufficiency and 46,XY disorders of sexual development (DSD). The lipoid CAH phenotype, including spontaneous puberty in 46,XX females, is explained by a two-hit model. StAR mutations that retain partial function cause milder non-classic disease characterized by glucocorticoid deficiency, with lesser disorders of mineralocorticoid and sex steroid synthesis. Rare P450scc mutations are clinically and hormonally indistinguishable from lipoid CAH, and may also present as milder non-classic disease. Adrenal imaging may distinguish these but is not 100% reliable, necessitating DNA sequencing.
How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase II trial, including issues such as how the treatment works, choice of outcome measure and randomization, and considering both academic and industry perspectives. A comprehensive and systematic library of available phase II trial designs is included, saving time otherwise spent considering multiple manuscripts, and real-life practical examples of using this approach to design phase II trials in cancer are given. A Practical Guide to Designing Phase II Trials in Oncology: Offers a structured and practical approach to phase II trial design Considers trial design from both an academic and industry perspective Includes a structured library of available phase II trial designs Is relevant to both clinical and statistical researchers at all levels Includes real life examples of applying this approach For those new to trial design, A Practical Guide to Designing Phase II Trials in Oncology will be a unique and practical learning tool, providing an introduction to the concepts behind informed decision making in phase II trials. For more experienced practitioners, the book will offer an overview of new, less familiar approaches to phase II trial design, providing alternative options to those which they may have previously used.
This collection of 12 new essays will tell the story of how the gradual transformation of industrial society into service-driven postindustrial society affected black life and culture in the city between 1900 and 1950, and it will shed light on the development of those forces that wreaked havoc in the lives of African Americans in the succeeding epoch. The book will examine the black urban experience in the northern, southern and western regions of the U.S. and will be thematically organized around the themes of work, community, city buliding, and protest. the analytic focus will be on the efforts of African Americans to find work and build communities in a constant ly changing economy and urban environments, tinged with racism,hostility, and the notions of white supremacy. Some chapters will be based on original research, while others will represent a systhesis of existing literature on that topic.
Rural crime is a fast growing area of interest among scholars in criminology. From studies of agricultural crime in Australia, to violence against women in Appalachia America, to poaching in Uganda, to land theft in Brazil -- the criminology community has come to recognize that crime manifests itself in rural localities in ways that both conform to and challenge conventional theory and research. For the first time, Rural Criminology brings together contemporary research and conceptual considerations to synthesize rural crime studies from a critical perspective. This book dispels four rural crime myths, challenging conventional criminological theories about crime in general. It also examines both the historical development of rural crime scholarship, recent research and conceptual developments. The third chapter recreates the critical in the rural criminology literature through discussions of three important topics: community characteristics and rural crime, drug use, production and trafficking in the rural context, and agricultural crime. Never before has rural crime been examined comprehensively, using any kind of theoretical approach, whether critical or otherwise. Rural Criminology does both, pulling together in one short volume the diverse array of empirical research under the theoretical umbrella of a critical perspective. This book will be of interest to those studying or researching in the fields of rural crime, critical criminology and sociology.
In this capstone work, Arthur Staats synthesizes more than four decades of research, theory, and study into a new generation of behaviorism that offers insights and future directions for researchers, professionals, and students. Staats's unified theory of psychological behaviorism builds on current theories in child development, personality, psychological measurement, and abnormal behavior. His theoretical model provides new ways to consider human behavior as a whole that will have implications for research, theory, and practice.
The concept of critical criminology – that crime and the present day processes of criminalization are rooted in the core structures of society – is of more relevance today than it has been at any other time. Written by an internationally renowned scholar, Contemporary Critical Criminology introduces the most up-to-date empirical, theoretical, and political contributions made by critical criminologists around the world. In its exploration of this material, the book also challenges the erroneous but widely held notion that the critical criminological project is restricted to mechanically applying theories to substantive topics, or to simple calling for radical political, economic, cultural, and social transformations. This book is an essential source of reference for both undergraduate and postgraduate students of Criminology, Criminal Theory, Social Policy, Research Methodology, and Penology.
The social sciences have sophisticated models of choice and equilibrium but little understanding of the emergence of novelty. Where do new alternatives, new organizational forms, and new types of people come from? Combining biochemical insights about the origin of life with innovative and historically oriented social network analyses, John Padgett and Walter Powell develop a theory about the emergence of organizational, market, and biographical novelty from the coevolution of multiple social networks. In the short run, they argue, actors make relations, but in the long run, they argue, actors make actors. Organizational novelty arises from spillover across intertwined networks, which tips reproducing biographical and production flows. This theory is developed through formal deductive modeling and through a wide range of careful and original historical case studies, ranging from early capitalism and state formation, to the transformation of communism, to the emergence of contemporary biotechnology and Silicon Vally. -- from back cover.
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