A "masterly" account of the origins of the transcontinental railroad (Douglas Brinkley) by the author of the bestselling The Admirals. After the completion of the first transcontinental railroad in 1869, the rest of the United States was up for grabs, and the race was on. The prize: a better, shorter, less snowy route through the American Southwest, linking Los Angeles to Chicago. In Iron Horses, Borneman recounts the rivalries, contested routes, political posturing, and business dealings that unfolded as an increasing number of lines pushed their way across the country. Borneman brings to life the legendary robber barons behind it all and also captures the herculean efforts required to construct these roads -- the laborers who did the back-breaking work, the brakemen who ran atop moving cars, the tracklayers crushed and killed by runaway trains. From backroom deals in Washington, DC, to armed robberies of trains in the wild deserts, from cattle cars to streamliners and Super Chiefs, all the great incidents and innovations of a mighty American era are made vivid in Iron Horses.
While international negotiations to reduce greenhouse gas (GHG) emissions have been less than satisfactory, there is a presumption that a significant level of multi-lateral commitment will be realized at some point. International air and marine travel have been left to one side in past talks because the pursuit of agreement proceeds on the basis of commitment by sovereign nations and the effects of these specific commercial activities are, by their nature, difficult to corral and assign to specific national jurisdictions. However, air travel is increasing and, unless something is done, emissions from this segment of our world economy will form a progressively larger percentage of the total, especially as emissions fall in other activities. This book focuses on fuel. The aim is to provide background in technical and policy terms, from the broadest reliable sources of information available, for the necessary discourse on society's reaction to the evolving aviation emissions profile. It considers what policy has been, why and how commercial air travel is committed to its current liquid fuel, how that fuel can be made without using fossil-source materials, and the barriers to change. It also advances some elements of policy remedies that make sense in providing an environmentally and economically sound way forward in a context that comprehends a more complete vision of sustainability than 'renewable fuels' traditionally have. The goal of Will Sustainability Fly? is to broaden and contextualize the knowledge resource available to academics, policy makers, air industry leaders and stakeholders, and interested members of the public.
International air and marine travel have been left to one side in past negotiations to reduce greenhouse gas (GHG) emissions, but unless something is done, emissions from this segment of the world economy will form a progressively larger percentage of the total, especially as emissions fall in other activities. Will Sustainability Fly? broadens and contextualizes the knowledge resource available to academics, policy makers, air industry leaders and stakeholders, and interested members of the public. The book focuses on fuel, providing background in technical and policy terms, from the broadest reliable sources of information available, for the necessary discourse on society's reaction to the evolving aviation emissions profile.
This title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1965.
Often called the most "Southern" of Southern cities, Charleston was one of the earliest urban centers in North America. It quickly became a boisterous, brawling sea city trading with distant ports, and later a capital of the Lowcountry plantations, a Southern cultural oasis, and a summer home for planters. In this city, the Civil War began. And now, in the twentieth century, its metropolitan area has evolved into a microcosm of "the military-industrial complex." This book records Charleston's development from 1670 and ends with an afterword on the effects of Hurricane Hugo in 1989, drawing with special care on information from every facet of the city's life—its people and institutions; its art and architecture; its recreational, social and intellectual life; its politics and city government. The most complete social, political, and cultural history of Charleston, this book is a treasure chest for historians and for anyone interested in delving into this lovely city, layer by layer.
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
Did you know that high levels of toxins in the human body can be linked to common conditions such as infertility, obesity, rheumatoid arthritis, heart disease, and diabetes? With therapeutic guidance designed for clinicians, Clinical Environmental Medicine focuses on how toxins such as arsenic, lead, mercury and organophosphates have become one of the leading causes of chronic disease in the industrial world. The first edition of this text describes how to treat these undesirable elements and molecules that can poison enzyme systems, damage DNA, increase inflammation and oxidative stress, and damage cell membranes. Expert authors Walter Crinnion and Joseph E. Pizzorno offer practical guidance for assessing both total body load as well as specific toxins. In addition, evidence-based treatment procedures provide recommendations for decreasing toxin exposure and supporting the body's biotransformation and excretion processes. - NEW! Unique! Practical diagnostic and therapeutic guidance designed for clinicians. - NEW! Unique! Coverage of the most common diseases for which toxins are a primary cause. - NEW! Description of how each toxin causes damage provides insights into sources, body load, and interventions for each toxin. - NEW! Unique! Entirely evidence-based content focuses on the most common conditions from which patients suffer. - NEW! Unique! Coverage of environmental toxicants, endogenous toxicants, and "toxins of choice" focuses on non-industrially-exposed populations.
From the development of each vaccine to its use in reducing disease, Plotkin's Vaccines, 7th Edition, provides the expert information you need to provide optimal care to your patients. This award-winning text offers a complete understanding of each disease, as well as the latest knowledge of both existing vaccines and those currently in research and development. Described by Bill Gates as "an indispensable guide to the enhancement of the well-being of our world," Plotkin's Vaccines is a must-have reference for current, authoritative information in this fast-moving field. - Includes complete information for each disease, including clinical characteristics, microbiology, pathogenesis, diagnosis, and treatment, epidemiology, and public health and regulatory issues – plus complete information for each vaccine, including its stability, immunogenicity, efficacy, duration of immunity, adverse events, indications, contraindications, precautions, administration with other vaccines, and disease-control strategies. - Analyzes the cost-benefit and cost-effectiveness of different vaccine options. - Helps you clearly visualize concepts and objective data through an abundance of tables and figures. - Covers the new oral cholera and zoster vaccines, as well as newly licensed meningococcal group B vaccines and a newly licensed dengue vaccine. - Brings you up to date on successful human trials of Ebola vaccines, an enterovirus 71 vaccine licensed in China, and new recommendations and changes to polio vaccines. - Features a new chapter on maternal immunization. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Although they are relative latecomers on the evolutionary scene, having emerged only 135?170 million years ago, angiosperms—or flowering plants—are the most diverse and species-rich group of seed-producing land plants, comprising more than 15,000 genera and over 350,000 species. Not only are they a model group for studying the patterns and processes of evolutionary diversification, they also play major roles in our economy, diet, and courtship rituals, producing our fruits, legumes, and grains, not to mention the flowers in our Valentine’s bouquets. They are also crucial ecologically, dominating most terrestrial and some aquatic landscapes. This fully revised edition of Phylogeny and Evolution of the Angiosperms provides an up-to-date, comprehensive overview of the evolution of and relationships among these vital plants. Incorporating molecular phylogenetics with morphological, chemical, developmental, and paleobotanical data, as well as presenting a more detailed account of early angiosperm fossils and important fossil information for each evolutionary branch of the angiosperms, the new edition integrates fossil evidence into a robust phylogenetic framework. Featuring a wealth of new color images, this highly synthetic work further reevaluates long-held evolutionary hypotheses related to flowering plants and will be an essential reference for botanists, plant systematists, and evolutionary biologists alike.
Geosciences and in particular numerical weather prediction are demanding the highest levels of available computer power. The European Centre for Medium-Range Weather Forecasts, with its experience in using supercomputers in this field, organizes every other year a workshop bringing together manufacturers, computer scientists, researchers and operational users to share their experiences and to learn about the latest developments. This book provides an excellent overview of the latest achievements in and plans for the use of new parallel techniques in meteorology, climatology and oceanography. The proceedings have been selected for coverage in: . OCo Index to Scientific & Technical Proceedings (ISTP CDROM version / ISI Proceedings).
Covering both the theoretical and practical aspects of critical care,Irwin & Rippe’s Intensive Care Medicine, Ninth Edition, provides state-of-the-art, evidence-based knowledge for specialty physicians and non-physicians practicing in the adult intensive care environment. Drs. Craig M. Lilly, Walter A. Boyle, and Richard S. Irwin, along with a team of expert contributing authors and education expert, William F. Kelly, offer authoritative, comprehensive guidance from an interprofessional, collaborative, educational, and scholarly perspective, encompassing all adult critical care specialties.
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