This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
This authoritative, research-based collection examines urgent threats to future global food security and evaluates current and potential solutions. Critical Food Issues: Problems and State-of-the-Art Solutions Worldwide examines 31 crucial areas of concern, from soil degradation, depletion of water for irrigation, and loss of biodiversity to declining rural livelihoods, hunger and obesity, unjust farm labor practices, and farm animal mistreatment. Critical Food Issues divides its coverage into two exhaustive volumes, one on bioenvironmental topics and one with a sociocultural focus. Throughout, highly accomplished experts from a variety of academic backgrounds review the current state of research on specific problems, then identify strategies for confronting those problems that balance sustainable agrifood systems with environmental stewardship, healthy people, and equitable communities. At a time of increasing public outcries over the quality of food and the impact of agrifood production on long-term environmental and human well-being, Critical Food Issues offers an authoritative and comprehensive basis on which producers, consumers, and citizens can make more informed decisions about the future of food.
This is a true story of two siblings, Sophie and David, who are separated by the Bolshevik Revolution and World War I. Sophie and her family immigrated to America in 1913, but David stayed in Russia, and was drafted into the tsars army. Their families stayed in touch until the mid 30s, when one could be arrested for receiving mail or packages from America or Germany. Then silence. For a long time, the relatives in America thought their cousins were dead. The silence was broken sixty years later, when Donna and Lilli, granddaughters of Sophie and David, providentially met in Germany. Born only one day apart, the two cousins have each exchanged information about what happened during those years of separation and silence. They write, visit back and forth, and even took a frightening trip to Russia, where Donna began to understand what the family had to endure under Communism. In these pages, you will meet Russian rulers from Catherine the Great to Mikhail Gorbachev, and see how their decisions impacted our cousins who still lived in Russia. The Iron Curtain lifts for us to get a glimpse of what life was like in Russia after Sophie immigrated before WWI and the Berlin Wall came down in 1989. Donna and Lilli have joined together to tell the many dramatic stories in the familys fight for survival.
This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of the book describes the network of damage-associated molecular pattern molecules (DAMPs) and examines the central role of DAMPs in cellular stress responses and associated regulated cell death, the promotion and resolution of inflammation, the activation of innate lymphoid cells and unconventional T cells, the stimulation of adaptive immunity, and tissue repair. The significance of DAMPs in a wide range of human diseases will then be explored in Volume II of the book, with discussion of the implications of injury-induced innate immunity for present and future treatments. This book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from immunity and inflammation research into clinical practice. The readership will include practitioners and clinicians such as hematologists, rheumatologists, traumatologists, oncologists, intensive care anesthetists, endocrinologists such as diabetologists, psychiatrists, neurologists, pharmacists, and transplantologists.
The core of this three-volume book deals with damage-associated molecular patterns abbreviated “DAMPs”, which are unique molecules that save life and fight for survival of all organisms on this planet by triggering robust inflammatory/immune defense responses upon any injury, including those caused by pathogens such as viruses and bacteria. However, these molecules also have a dark side: when produced in excess upon severe insults, they can trigger serious human diseases. The three volumes present current understanding of the importance of DAMP-promoted immune responses in the etiopathogenesis of human diseases and explore how this understanding is impacting diagnosis, prognosis, and future treatment. This third volume addresses the potential of DAMPs in clinical practice, as therapeutic targets and therapeutics, by focusing on a description of antigen-related diseases, which are pathogenetically dominated by DAMPs, that is, infectious and autoimmune disorders and allograft rejection (as an undesired function of these molecules), as well as tumor rejection (as the desired function of these molecules). The book is written for professionals from all medical and paramedical disciplines who are interested in the introduction of innovative data from modern inflammation and immunity research into clinical practice. In this sense, the book reflects an approach to translational medicine. The readership will include all practitioners and clinicians, in particular, ICU clinicians, infectiologists, microbiologists, virologists, hematologists, rheumatologists, diabetologists, neurologists, transplantologists, oncologists, and pharmacists. Also available: Damage-Associated Molecular Patterns in Human Diseases - Vol. 1: Injury-Induced Innate Immune Responses; Damage-Associated Molecular Patterns in Human Diseases - Vol. 2: Danger Signals as Diagnostics, Prognostics, and Therapeutic Targets.
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