Content: The book is organized into three parts: Simulation Concepts, Simulation Model-Building with Simio, and Case Studies Using Simio. Each part is composed of two to six focused chapters. While the book as a whole will be fully integrated, the various chapters could stand alone as a module of a few weeks in a larger survey course, as well as serve as the foundation of a whole course on simulation that would go on to include some or all of the last three parts. Author Statement: Our objective is for this book to serve as the primary text in introductory and perhaps second courses in simulation at both the undergraduate and beginning-graduate levels. The text or components of it could also support a simulation module of a few weeks within a larger survey course in programs without a stand-alone simulation course (e.g., MBA). It is written in an accessible tutorial-style writing approach centered around specific examples rather than general concepts, and covers a variety of applications including an international flavor.