Brew up your own business. This is a step-by-step guide to realizing what for many people is a cherished dream: opening a successful coffee bar. The Complete idiot's Guide to Starting and Running a Coffee Bar includes the dirt on what it's really like to work behind the counter and information of everything from how to build a business plan, to how to make the drinks and how to price them. - Only series book of its kind - The specialty coffee business is still growing - Small businesses create 7 out of 10 new jobs in America - Susan Gilbert has started and run five successful coffee bars
Timekeeping: Explore the History and Science of Telling Time travels through the past and into the future to explore how humans have measured the passage of time. From ancient civilization’s earliest calendars and shadow clocks to GPS and the atomic clocks of today, kids will track the evolution of timekeeping devices, meet the inventors of calendars and clocks, and learn interesting facts and trivia. Hands-on projects and activities include making a shadow clock, using a protractor to create a sundial, measuring time using water, and creating your own calendar. Kids will understand how civilization’s vague abilities to track days and months has transformed over the centuries into a sophisticated ability to keep time to the millionth of a second.
This book will help you sort through America's giant corporate employers to determine which may be the best for corporate employers to determine which may be the best for you, or to see how your current employer compares to others. It has reference for growth and hiring plans, salaries and benefits, women and minority advancement, industries, locations and careers, and major trends affecting job seekers.
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. - Updates to all chapters, including new examples and references - Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book - Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry - Chapter 3 (Receptors): Drug-receptor interactions, cation-p and halogen bonding; atropisomers; case history of the insomnia drug suvorexant - Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis - Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: - for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib - for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid - for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin - Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples - Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites - Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
No other guide covers the complete retail picture like this exciting new volume. America's retail industry is in the midst of vast changes - superstores and giant discounters are popping up on major corners. Malls are lagging while "power centers" are surging ahead. Savvy firms are combining bricks, clicks and catalogs into multi-channel retail powerhouses. Which are the hottest retailers? What lies ahead? Our market research section shows you the trends and a thorough analysis of retail technologies, chain stores, shopping centers, mergers, finances and future growth within the industry. Included are major statistical tables showing everything from monthly U.S. retail sales, by sector, to mall sales per square foot, to the 10 largest malls in the US. Meanwhile, the corporate profiles section covering nearly 500 firms gives you complete profiles of the leading, fastest growing retail chains across the nation. From Wal-Mart and Costco to Barnes & Noble and Amazon, we profile the major companies that marketing executives, investors and job seekers most want to know about. These profiles include corporate name, address, phone, fax, web site, growth plans, competitive advantage, financial histories and up to 27 executive contacts by title. Purchasers of the printed book or PDF version may receive a free CD-ROM database of the corporate profiles, enabling export of vital corporate data for mail merge and other uses.
Newfoundland and Labrador has a long history of commercial whaling, beginning in the first half of the sixteenth century when Basque whalers established seasonal stations on the Labrador coast from which to hunt bowheads and North Atlantic right whales. Anthony Dickinson and Chesley Sanger examine the region's modern shore-station industry from its beginnings in 1896 to its peak catch season in 1904 through subsequent cycles of decline and revival until its enforced closure in 1972 by the federal government.Modern shore-station whaling on Canada's eastern shores developed with the spread of Norwegian-dominated whaling from local areas where stocks that had been depleted by new hunting technologies to more productive locations in the North Atlantic and elsewhere. Twentieth-Century Shore-Station Whaling in Newfoundland and Labrador adds to a growing number of regionally specific case studies that collectively illustrate the complex nature of the history of global whaling. Dickinson and Sanger further demonstrate how participants in the industry were instrumental in developing other whaling initiatives, including those in British Columbia.
Examines how imago Dei, the Christian belief that all people are made in God's image, influenced Martin Luther King Jr. and affected his civil rights work.
This is a brand-new, updated history of the Nuremburg Raid, taking advantage of new stores of information that have come to light in recent years. In his usual, highly-praised style, Martin Bowman's historical narrative is supplemented throughout by first-hand snippets of pilot testimony, offering an authentic sense of events as they played out. Having access to extensive archives of images ensures that this is a visually pleasing and comprehensive account of one of the most iconic raids of the Second World War.
The San Francisco 49ers have one of the best records in NFL history, with 20 division championships, seven conference titles, and five Super Bowl championships. On a team with outstanding talent each year, who among its past and present players could be ranked as the 50 greatest? Who would occupy the coveted #1 spot? Jerry Rice? Ronnie Lott? Joe Montana? Steve Young? Robert Cohen has his own take on the matter and, in a book that is bound to inspire conversation if not controversy, ranks who he believes are the greatest players from 1 to 50, with 25 honorable mentions.
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