Addiction is one of the most challenging health problems. It is associated with enormous individual distress and tremendous socioeconomic consequences. Unfortunately, its underlying mechanisms are not fully understood, and pharmacological, psychological, or social interventions often fail to achieve long-lasting remission. Next to genetic, social, and contextual factors, a substance-induced dysfunction of the brain’s reward system is considered a decisive factor for the establishment and maintenance of addiction. Due to its successful application and approval for several neurological disorders, deep brain stimulation (DBS) is known as a powerful tool for modulating dysregulated networks and has also been considered for substance addiction. Initial promising case reports of DBS in alcohol and heroin addiction in humans have recently been published. Likewise, results from animal studies mimicking different kinds of substance addiction point in a similar direction. The objective of this review is to provide an overview of the published results on DBS in addiction, and to discuss whether these preliminary results justify further research, given the novelty of this treatment approach.
In 1958, Shepard Stone, then directing the Ford Foundation's International Affairs program, suggested that his staff "measure" America's cultural impact in Europe. He wanted to determine whether efforts to improve opinions of American culture were yielding good returns. Taking Stone's career as a point of departure and frequent return, Volker Berghahn examines the triangular relationship between the producers of ideas and ideologies, corporate America, and Washington policymakers at a peculiar juncture of U.S. history. He also looks across the Atlantic, at the Western European intellectuals, politicians, and businessmen with whom these Americans were in frequent contact. While shattered materially and psychologically by World War II, educated Europeans did not shed their opinions about the inferiority, vulgarity, and commercialism of American culture. American elites--particularly the East Coast establishment--deeply resented this condescension. They believed that the United States had two culture wars to win: one against the Soviet Bloc as part of the larger struggle against communism and the other against deeply rooted negative views of America as a civilization. To triumph, they spent large sums of money on overt and covert activities, from tours of American orchestras to the often secret funding of European publications and intellectual congresses by the CIA. At the center of these activities were the Ford Foundation, the Congress for Cultural Freedom, and Washington's agents of cultural diplomacy. This was a world of Ivy League academics and East Coast intellectuals, of American philanthropic organizations and their backers in big business, of U.S. government agencies and their counterparts across the Atlantic. This book uses Shepard Stone as a window to this world in which the European-American relationship was hammered out in cultural terms--an arena where many of the twentieth century's major intellectual trends and conflicts unfolded.
Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.
Active Galactic Nuclei This AGN textbook gives an overview on the current knowledge of the Active Galacitc Nuclei phenomenon. The spectral energy distribution will be discussed, pointing out what can be observed in different wavebands. The different physical models are presented together with formula important for the understanding of AGN physics. Furthermore, the authors discuss the AGN with respect to its environment, host galaxy, feedback in galaxies and in clusters of galaxies, variability, etc. and finally the cosmological evolution of the AGN phenomenon. This book includes phenomena based on new results in the X-Ray and gamma-ray domain from new telescopes such as Chandra, XMM-Newton, the Fermi Gamma-Ray Space Telescope, and the VHE regime not mentioned so far in AGN books. Those and other new developments as well as simulations of AGN merging events and formations, enabled through latest super-computing capabilities. From the contents: The observational picture of AGN Radiative processes The central engine AGN types and unification AGN through the electromagnetic spectrum AGN variability Environment Quasars and cosmology Formation, evolution and the ultimate fate of AGN What we do not know (yet)
A riveting account of the dictator’s final years, when he got the war he wanted but led his nation, the world, and himself to catastrophe—from the author of Hitler: Ascent “Skillfully conceived and utterly engrossing.” —The New York Times Book Review In the summer of 1939, Hitler was at the zenith of his power. Having consolidated political control in Germany, he was at the helm of a newly restored major world power, and now perfectly positioned to realize his lifelong ambition: to help the German people flourish and to exterminate those who stood in the way. Beginning a war allowed Hitler to take his ideological obsessions to unthinkable extremes, including the mass genocide of millions, which was conducted not only with the aid of the SS, but with the full knowledge of German leadership. Yet despite a series of stunning initial triumphs, Hitler’s fateful decision to invade the Soviet Union in 1941 turned the tide of the war in favor of the Allies. Now, Volker Ullrich, author of Hitler: Ascent 1889–1939, offers fascinating new insight into Hitler’s character and personality. He vividly portrays the insecurity, obsession with minutiae, and narcissistic penchant for gambling that led Hitler to overrule his subordinates and then blame them for his failures. When he ultimately realized the war was not winnable, Hitler embarked on the annihilation of Germany itself in order to punish the people who he believed had failed to hand him victory. A masterful and riveting account of a spectacular downfall, Ullrich’s rendering of Hitler’s final years is an essential addition to our understanding of the dictator and the course of the Second World War.
Anyone who is travelling outdoors and relies on the weather forecast knows the situation: you try to understand the weather forecast in the local language. Most of the time you understand it, but you are missing a key word to understand it exactly. Or you are discussing the weather report in a multilingual group and the key word is missing. General dictionaries are not helpful as soon as terms are not translated literally. The weather vocabulary is designed to help you in this situation. It contains several thousand meteorological expressions. Once you have found the right word in the other language, you can search the Internet for an explanation. A must for air sports enthusiasts, sailors, water sports enthusiasts, mountaineers, hikers and anyone who needs to understand the weather.
This book focuses on the important work of Karl Mannheim by demonstrating how his theoretical conception of a reflexive sociology took shape as a collaborative empirical research programme. The authors show how contemporary work along these lines can benefit from the insights of Mannheim and his students into both morphology and genealogy. It returns Mannheim's sociology of knowledge inquiries into the broader context of a wider project in historical and cultural sociology, whose promising development was disrupted and then partially obscured by the expulsion of Mannheim's intellectual generation. This inspired volume will appeal to sociologists concerned with the contemporary relevance of his work, and who are prepared for a fresh look at Weimar sociology and the legacy of Max Weber.
The Army Materials and Mechanics Research Center of Water town, Massachusetts in cooperation with the Materials Science Group of the Department of Chemical Engineering and Materials Science of Syracuse University has conducted the Sagamore Army Materials Research Conference since 1954. The main purpose of these conferences has been to gather together over 150 scientists and engineers from academic institutions, industry and government who are uniquely qualified to explore in depth a subject of importance to the Department of Defense, the Army and the scientific community. This volume NONDESTRUCTIVE EVALUATION OF MATERIALS, addresses the areas of x-ray, ultrasonics and other methods of nondestructive testing. We wish to acknowledge the dedicated assistance of Joseph M. Bernier of the Army Materials and Mechanics Research Center and Helen Brown DeMascio of Syracuse University throughout the stages of the conference planning and finally the publication of this book. Their help is deeply appreciated. Syracuse University Syracuse, New York The Editors Contents SESSION I X-RAY S. Heissman, Moderator H. K. Herglotz, Moderator 1. Overview of X-Ray Diffraction Methods for Nondestructive Testing • • • • • • • ••• 1 L. V. Azaroff 2. Detection of Fatigue Damage by X-Rays 21 S. Taira and K. Kamachi 3. A Historical Example of Fatigue Damage • • • • • • • 55 H. K. Herglotz 4. The Application of X-Ray Topography to Materials Science . . . . . . . . . . . . . . . . . . . . 69 S. Weissman 5.
The origins of the mathematics in this book date back more than two thou sand years, as can be seen from the fact that one of the most important algorithms presented here bears the name of the Greek mathematician Eu clid. The word "algorithm" as well as the key word "algebra" in the title of this book come from the name and the work of the ninth-century scientist Mohammed ibn Musa al-Khowarizmi, who was born in what is now Uzbek istan and worked in Baghdad at the court of Harun al-Rashid's son. The word "algorithm" is actually a westernization of al-Khowarizmi's name, while "algebra" derives from "al-jabr," a term that appears in the title of his book Kitab al-jabr wa'l muqabala, where he discusses symbolic methods for the solution of equations. This close connection between algebra and al gorithms lasted roughly up to the beginning of this century; until then, the primary goal of algebra was the design of constructive methods for solving equations by means of symbolic transformations. During the second half of the nineteenth century, a new line of thought began to enter algebra from the realm of geometry, where it had been successful since Euclid's time, namely, the axiomatic method.
This book is about the mathematical theory of light propagation in media on general-relativistic spacetimes. The first part discusses the transition from Maxwell's equations to ray optics. The second part establishes a general mathematical framework for treating ray optics as a theory in its own right, making extensive use of the Hamiltonian formalism. This part also includes a detailed discussion of variational principles (i.e., various versions of Fermat's principle) for light rays in general-relativistic media. Some applications, e.g. to gravitational lensing, are worked out. The reader is assumed to have some basic knowledge of general relativity and some familiarity with differential geometry. Some of the results are published here for the first time, e.g. a general-relativistic version of Fermat's principle for light rays in a medium that has to satisfy some regularity condition only.
A comprehensive history of German society in this period, providing a broad survey of its development. The volume is thematically organized and designed to give easy access to the major topics and issues of the Bismarkian and Wilhelmine eras. The statistical appendix contains a wide range of social, economic and political data. Written with the English-speaking student in mind, this book is likely to become a widely used text for this period, incorporating as it does twenty years of further research on the German Empire since the appearance of Hans-Ulrich Wehler's classic work.
Influenced by Hegel and Nietzsche, and inspired by stays in Italy and France, as well as travels to Russia, Spain, and North Africa, Rainer Maria Rilke nevertheless sought desperately to be original. He rejected all «idées reçues, » whether they were of God, reality, or literature, instead creating his own absolute. He searched for the «real, » re-formed German poetry, and revolutionized Western narrative prose with Malte Laurids Brigge. While Rilke's work is marked by two cesuras, after which it displays important advances in diction and the figuration of verbal icons, it becomes ever more esoteric. However, there are also constants throughout his oeuvre in thematics, topoi, and diction - for example, the preoccupation with death, figures such as the angel, key nouns, alliterations, and noun sequences. His fear of death drove him to adopt «the open, » an idea conceived by the dubious mystagogue Alfred Schuler that surfaces throughout Rilke's poetry and triumphs in Sonnets to Orpheus and Duino Elegies.
The moral and political role of German journalists before, during, and after the Nazi dictatorship Journalists between Hitler and Adenauer takes an in-depth look at German journalism from the late Weimar period through the postwar decades. Illuminating the roles played by journalists in the media metropolis of Hamburg, Volker Berghahn focuses on the lives and work of three remarkable individuals: Marion Countess Dönhoff, distinguished editor of Die Zeit; Paul Sethe, “the grand old man of West German journalism”; and Hans Zehrer, editor in chief of Die Welt. All born before 1914, Dönhoff, Sethe, and Zehrer witnessed the Weimar Republic’s end and opposed Hitler. When the latter seized power in 1933, they were, like their fellow Germans, confronted with the difficult choice of entering exile, becoming part of the active resistance, or joining the Nazi Party. Instead, they followed a fourth path—“inner emigration”—psychologically distancing themselves from the regime, their writing falling into a gray zone between grudging collaboration and active resistance. During the war, Dönhoff and Sethe had links to the 1944 conspiracy to kill Hitler, while Zehrer remained out of sight on a North Sea island. In the decades after 1945, all three became major figures in the West German media. Berghahn considers how these journalists and those who chose inner emigration interpreted Germany’s horrific past and how they helped to morally and politically shape the reconstruction of the country. With fresh archival materials, Journalists between Hitler and Adenauer sheds essential light on the influential position of the German media in the mid-twentieth century and raises questions about modern journalism that remain topical today.
“Fascinating . . . a must read for those who are interested in the Normandy, Market Garden, and Ardennes Operations” (Henrik Lunde, author of Hitler’s Preemptive War). This is the complete wartime history of one of the largest German paratrooper regiments, the 6th, from its initial formation in the spring of 1943 to its last day at the end of the war. With numerous firsthand accounts from key members reporting on their experiences, they describe the events of 1943–45 vividly and without compromise. These accounts reveal previously unknown details about important operations in Italy, Russia, Belgium, and Holland, and on the Normandy Front, the last German Parachute drop in the Ardennes, and the final battle to the end in Germany. With over 220 original photographs, many from private collections and never before published, this book fully illustrates the men, their uniforms, equipment, and weapons. Also included is an appendix with maps, battle calendar, staffing plans, a list of field numbers, and the Knight’s Cross recipients of the regiment. Having earned the respect of the Allied forces who fought against it during World War II, this work will inform current readers of the full record of Fallschirmjäger Regiment 6, and why the Allied advance into German-held Europe was so painstaking to achieve. “The great value of Griesser’s superb, richly detailed, and fabulously illustrated work is that it fills in a very wide gap in our knowledge about one of Nazi Germany’s elite branches of service . . . The Lions of Carentan represents a treasure trove for anyone interested in German airborne forces.” —Flint Whitlock, author of If Chaos Reigns
This is the second updated and extended edition of the successful book on Feynman-Kac theory. It offers a state-of-the-art mathematical account of functional integration methods in the context of self-adjoint operators and semigroups using the concepts and tools of modern stochastic analysis. The first volume concentrates on Feynman-Kac-type formulae and Gibbs measures.
The third edition of this classic in the field is completely updated and revised with approximately 30% new content so as to include the latest developments. The handbook and ready reference comprehensively covers nuclear and radiochemistry in a well-structured and readily accessible manner, dealing with the theory and fundamentals in the first half, followed by chapters devoted to such specific topics as nuclear energy and reactors, radiotracers, and radionuclides in the life sciences. The result is a valuable resource for both newcomers as well as established scientists in the field.
Volker Elis Pilgrim (1942-2022) was a bestselling author in Germany, publishing a range of controversial books such as his study of the evils of mother love, a guide to sexual emancipation, and four massive volumes which psychoanalyzed Hitler as a sexually deranged serial killer. The Vampire Man, completed just before his death, is his first book in English. It has an important message: there are vampires among us, killing us softly in our sleep. His book presents a brilliant investigation into a phenomenon that affects millions of people. Pilgrim has detected a sleep disorder which he describes as “an energy transfer” between two people who sleep in different rooms, even in different buildings. It’s a kind of clandestine relationship. His theory is that there is a taker, who feeds off the spirits of someone else in their sleep – and robs them even of the will to live. Such takers, Pilgrim believes, have a vampire personality. Their victims are donors. They suffer from restlessness and deep disturbance in the night and are mystified about what causes their disorder. Pilgrim’s book is a warning – and offers help to donors so they can avoid “nightly energy robbery.” The author was once described as “the most interesting person on Earth.” The Vampire Man introduces the English-reading world to a profound and towering genius – and his book may even save lives.
This biography sheds light on all facets of the life and the achievements of Ernst Zermelo (1871-1953). Zermelo is best-known for the statement of the axiom of choice and his axiomatization of set theory. However, he also worked in applied mathematics and mathematical physics. His dissertation, for example, promoted the calculus of variations, and he created the pivotal method in the theory of rating systems. The presentation of Zermelo's work explores motivations, aims, acceptance, and influence. Selected proofs and information gleaned from letters add to the analysis. The description of his personality owes much to conversations with his late wife Gertrud. This second edition provides additional information. The system of citations has been adapted to that of Zermelo's Collected Works in order to facilitate side-by-side reading and thus profit from the thorough commentaries written for the Collected Works by experts in the respective fields. All facts presented are documented by appropriate sources. The biography contains nearly 50 photos and facsimiles.
The third edition of this classic in the field is completely updated and revised with approximately 30% new content so as to include the latest developments. The handbook and ready reference comprehensively covers nuclear and radiochemistry in a well-structured and readily accessible manner, dealing with the theory and fundamentals in the first half, followed by chapters devoted to such specific topics as nuclear energy and reactors, radiotracers, and radionuclides in the life sciences. The result is a valuable resource for both newcomers as well as established scientists in the field.
A comprehensive history of German society in this period, providing a broad survey of its development. The volume is thematically organized and designed to give easy access to the major topics and issues of the Bismarkian and Wilhelmine eras. The statistical appendix contains a wide range of social, economic and political data. Written with the English-speaking student in mind, this book is likely to become a widely used text for this period, incorporating as it does twenty years of further research on the German Empire since the appearance of Hans-Ulrich Wehler's classic work.
Examines 58 letters written by Katerina Lemmel, a wealthy Nuremberg widow, who in 1516 entered the abbey of Maria Mai in south Germany, and rebuilt the monastery using her own resources and the donations she solicited from relatives"--Provided by publisher.
We live in a digital Media Society, in which pictures are becoming more and more important. So, human communication is increasingly becoming a visual communication. That is not a new finding. But the new question is: What does this development mean for the law? Up to now the law is the part of the society which is most sceptical towards images. Law has still resisted the visual temptation. This will not last for ever. The rush of pictures in everyday life and in every part of the society is much too strong - and it is even getting stronger. The invasion of images will change the character of modern law deeply. Modern law will become a Pictorial Law.What are the chances and the risks of Pictorial Law and visual law communication? This is the topic of the book.
In our everyday imaginations we use the laws of nature with their tremendous possibilities of technical progress for the benefit of mankind. The three catastrophes of Chernobyl (26 April 1986), Fukushima Daichii (11 March 2011) and in the Gulf of Mexico, explosion of the drilling platform Deepwater Horizon (20 April 2010), have shaken this world view. Who directed this development? Is it a matter of human error or technical failure? For the answer, approaches from the natural sciences and the humanities are presented.
Text in English and German. The oeuvre of Stefan Wewerka occupies a unique position in post-war art because of the way in which he mixes different genres. Wewerka is an 'uomo universale', an uncomfortable pedagogue, a bringer of enlightenment. In addition to his practical work as an architect -- his competition entries have had a lasting effect on architectural discourse -- he has alienated architecture photographically or with the aid of traditional artistic techniques, has written books, has painted pictures, has made films and object art. In the early 50s Wewerka involved himself in earth architecture -- early attempts to build with nature and not against it -- and this at a time when no one was talking about ecology or even green building. Wewerka became known to a wider public in the 60s by the artistic allenation of chairs and other everyday objects, which he sawed up or distorted in order to undermine familiar images subversively. He also did not leave architectural 'high culture' untouched. Triumphal arches like the Arc de Triomphe in Paris or Gothic cathedrals heel over or buckle to form surreal structures and thus make their ideological claims questionable. In the late 70s Wewerka also started to design furniture which had high utility value despite its free form and which emanate an almost Bauhaus-like dignity. All this furniture, like the Fan Desk, the three-legged chair or the One-Swinger, and also his Kitchen Tree and the programmatic Cella furniture system stand like sculptures in the space and always derive a new and surprising variant from subjects and genres that seemed to be closed. The internationally known architecture and design historian Volker Fischer was vice director of the Deutsches Architekturmuseum in Frankfurt for over 10 years. For some time now he has been building up a new design department in the Museum fur Kunsthandwerk in Frankfurt; in addition to his museum work he teaches history of architecture and design at the Hochschule fur Gestaltung in Offenbach. Like Volker Fischer, architectural historian Andrea Gleiniger worked for many years in the Deutsches Architekturmuseum in Frankfurt; she now teaches at the Staatliche Hochschule fur Gestaltung in Karisruhe. Her principal working fields are the history of housing estates in the 20th century and the relationship between architecture, art and the new media.
The third edition of this popular core textbook provides wide-ranging coverage of the structure, internal working, policies and performance of international organizations such as the UN, EU, IMF and World Bank. Such organizations have never been so important in addressing the challenges that face our increasingly globalised world. This book introduces students to theories with which to approach international organizations, their history, and their ability to respond to contemporary issues in world politics from nuclear disarmament, climate change and human rights protection, to trade, monetary and financial relations, and international development. Underpinning the text is the authors' unique model that views international organizations as actual organizations. Reacting to world events, political actors provide the 'inputs' which are converted by the political systems of these organizations (through various decision-making procedures) into 'outputs' that achieve varying levels of real-world impact and effectiveness. This is the perfect text for undergraduate and postgraduate students of politics and international relations taking courses on International organization and global governance, as well as essential reading for those studying the UN, the EU and Globalization. New to this Edition: - Draws on the most recent research in the field and considers some of the significant world events of the last decade to ensure that the book is completely up to date. - Two separate chapters considering Trade and Development, and Finance and Monetary Relations respectively. - Fully accounts for the challenges to international organizations by the emerging powers, the Trump administration and Brexit
Covers art from the Middle Ages to contemporary movements, describing major works and their cultural contexts, and offering brief sketches of prominent artists for each period.
The aim of this book is to furnish the reader with a rigorous and detailed exposition of the concept of control parametrization and time scaling transformation. It presents computational solution techniques for a special class of constrained optimal control problems as well as applications to some practical examples. The book may be considered an extension of the 1991 monograph A Unified Computational Approach Optimal Control Problems, by K.L. Teo, C.J. Goh, and K.H. Wong. This publication discusses the development of new theory and computational methods for solving various optimal control problems numerically and in a unified fashion. To keep the book accessible and uniform, it includes those results developed by the authors, their students, and their past and present collaborators. A brief review of methods that are not covered in this exposition, is also included. Knowledge gained from this book may inspire advancement of new techniques to solve complex problems that arise in the future. This book is intended as reference for researchers in mathematics, engineering, and other sciences, graduate students and practitioners who apply optimal control methods in their work. It may be appropriate reading material for a graduate level seminar or as a text for a course in optimal control.
Diese Memoiren wurden kurz nach Kriegsende im DP-Lager Stuttgart-Degerloch auf Jiddisch verfasst und wurden von Volker Mall aus dem Englischen und Jiddischen übersetzt. Das Besondere an diesen Memoiren ist einmal der relativ frühe Zeitpunkt ihrer Entstehung, zum anderen enthalten sie bisher unbekannte Informationen über das KZ Außenlager Hailfingen/Tailfingen..
The writings of Volker Gerhardt have had substantial influence on recent Nietzsche research. This volume collects a variety of his influential essays and makes them available to scholars and causal readers alike. The present collection takes stock of Nietzsche's most prominent ideas. Gerhardt investigates which of these ideas still offer solutions for the problems of today. In the process, it becomes clear what sort of inspiration a future-oriented philosophizing can draw from Nietzsche.
This will help us customize your experience to showcase the most relevant content to your age group
Please select from below
Login
Not registered?
Sign up
Already registered?
Success – Your message will goes here
We'd love to hear from you!
Thank you for visiting our website. Would you like to provide feedback on how we could improve your experience?
This site does not use any third party cookies with one exception — it uses cookies from Google to deliver its services and to analyze traffic.Learn More.