The American WestÑwhere such landmarks as the Golden Gate Bridge rival wild landscapes in popularity and iconic significanceÑhas been viewed as a frontier of technological innovation. Where Minds and Matters Meet calls attention to the convergence of Western history and the history of technology, showing that the regionÕs politics and culture have shaped seemingly placeless, global technological practices and institutions. Drawing on political and social history as well as art history, the bookÕs essays take the cultural measure of the regionÕs great technological milestones, including San DiegoÕs Panama-California Exposition, the building of the Hetch Hetchy Dam in the Sierras, and traffic planning in Los Angeles. Contributors: Amy Bix, Louise Nelson Dyble, Patrick McCray, Linda Nash, Peter Neushul, Matthew W. Roth, Bruce Sinclair, L. Chase Smith, Carlene Stephens, Aristotle Tympas, Jason Weems, Peter Westwick, Stephanie Young
The book describes the properties, analytical methods and the applications of different polyvinylpyrrolidone excipients (povidone, crospovidone, copovidone etc.) for use in pharmaceutical preparations. This group of excipients is one of the most important excipients used in modern technology to produce drugs. The book is intended for all persons working in the research, development and quality control of drugs. It gives a survey of all applications in solid, liquid and semisolid dosage forms including many drug formulation examples and more than 600 references to the literature.
This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.
NEW YORK TIMES BESTSELLER • This landmark biography of Hitler puts an emphasis on the man himself: his personality, his temperament, and his beliefs. “[A] fascinating Shakespearean parable about how the confluence of circumstance, chance, a ruthless individual and the willful blindness of others can transform a country — and, in Hitler’s case, lead to an unimaginable nightmare for the world.” —Michiko Kakutani, The New York Times Volker Ullrich's Hitler, the first in a two-volume biography, has changed the way scholars and laypeople alike understand the man who has become the personification of evil. Drawing on previously unseen papers and new scholarly research, Ullrich charts Hitler's life from his childhood through his experiences in the First World War and his subsequent rise as a far-right leader. Focusing on the personality behind the policies, Ullrich creates a vivid portrait of a man and his megalomania, political skill, and horrifying worldview. Hitler is an essential historical biography with unsettling resonance in contemporary times.
English self-forms and related words from other Germanic languages (e.g. Dutch zelf, Swedish själv, etc.) are used in two different functions: as ‘intensifiers’ (e.g. The president himself made the decision) and as markers of reflexivity (John criticized himself). On the basis of a comparative syntactic and semantic analysis, this book addresses the question of why two such apparently different functions can be expressed by the same word. This question is answered by showing that both intensifying and reflexive self-forms can be analysed as expressing the concept of ‘identity’. In the first part of The Grammar of Identity, the most central facts concerning the distribution of intensifiers in Germanic languages are surveyed and a detailed syntactic and semantic analysis is provided. It is shown that all instances of intensifiers can be analysed as expressions of an identity function. The second part of the book offers an analysis of reflexive self-forms which is based on recent theories of reflexivity, modifying these in some important respects. In particular, the distribution of reflexive self-forms is explained with reference to semantic properties of the sentential environment. In this way, it can be shown that reflexive self-forms – like intensifiers – can be analysed as expressions of an identity function. In addition to providing a thorough comparative description of the hitherto poorly described area of intensifiers in Germanic languages, this book offers an answer to a long standing question in descriptive and theoretical linguistics, namely why self-forms are used in two apparently different functions. By combining analytical methods from syntax, lexical semantics and sentence semantics the study moreover contributes to an understanding of the interaction between structure, meaning and context in a central area of lexico-grammar.
This volume brings together experts on the quark-gluon structure of matter as it applies to nucleon resonance physics. The contributions discuss the latest findings in areas such as meson production via electromagnetic and hadronic reactions, baryon resonance structure in chiral and lattice QCD approaches, and the extraction of resonance parameters from coupled-channels analysis of data.
Rowing Science explains and applies up-to-date scientific research across all aspects of the sport to optimize rowing skills and performance, making it essential reading for serious rowers, coaches, and rowing scientists.
Strain Hardening Cement Composites, SHCC hereafter, demonstrate excellent mechanical behavior showing tensile strain hardening and multiple fine cracks. This strain hardening behavior improves the durability of concrete structures employing SHCC and the multiple fine cracks enhance structural performance. Reliable tensile performance of SHCC enables us to design structures explicitly accounting for SHCC’s tensile properties. Reinforced SHCC elements (R/SHCC) indicate large energy absorbing performance under large seismic excitation. Against various types of loads, R/SHCC elements can be designed by superimposing re-bar performance and SHCC’s tensile performance. This report focuses on flexural design, shear design, FE modeling and anti-seismic design of R/SHCC elements as well as application examples. Establishing design methods for new materials usually leads to exploring application areas and this trend should be demonstrated by collecting actual application examples of SHCC in structures.
The editors present a state-of-the-art overview on the Physics of Space Weather and its effects on technological and biological systems on the ground and in space. It opens with a general introduction on the subject, followed by a historical review on the major developments in the field of solar terrestrial relationships leading to its development into the up-to-date field of space weather. Specific emphasis is placed on the technological effects that have impacted society in the past century at times of major solar activity. Chapter 2 summarizes key milestones, starting from the base of solar observations with classic telescopes up to recent space observations and new mission developments with EUV and X-ray telescopes (e.g., STEREO), yielding an unprecedented view of the sun-earth system. Chapter 3 provides a scientific summary of the present understanding of the physics of the sun-earth system based on the latest results from spacecraft designed to observe the Sun, the interplanetary medium and geospace. Chapter 4 describes how the plasma and magnetic field structure of the earth's magnetosphere is impacted by the variation of the solar and interplanetary conditions, providing the necessary science and technology background for missions in low and near earth's orbit. Chapter 5 elaborates the physics of the layer of the earth's upper atmosphere that is the cause of disruptions in radio-wave communications and GPS (Global Positioning System) errors, which is of crucial importance for projects like Galileo. In Chapters 6-10, the impacts of technology used up to now in space, on earth and on life are reviewed.
Protection of the environment has nowadays become a major challenge and a condi tion for survival of future human generations and life on Earth in general. Yet it is still far too much of a dream or hope rather than a reality in the policy of our societies. Presently we are experiencing an unprecedented exponential growth of demography combined with a race for profit, resulting in excessive consumption particularly of en ergy, and a serious impact on the world ecosystems. Various types of pollutants and emerging new diseases not only disrupt the normal course of life, but also above this some of the atmospheric pollutants are most likely involved in the changing climate. We fear and literally shiver at the thought that the "changing climate" would ultimately disrupt the fragile thermodynamic equilibrium between the atmosphere and the oceans. Are we insensitive to these facts to the point of pushing our descendants, some genera tions ahead, into a new glacial period after a first period of warming up, at least, in northern Europe, like the one that took place 13 to 14 millennia ago? Surely the planet's nature is not prepared to be dominated by man and will go its way, whether humanity will be alive or dead.
The renowned WWII historian’s definitive biography of the notorious German SS officer convicted of war crimes for his role in the Holocaust. Described as one of the greatest mass-murderers in history, Rudolf Höss was the longest-serving commandant of the Auschwitz concentration and extermination camps in Nazi-occupied Poland. He was one of the chief architects behind Hitler’s Final Solution. In The Commandant of Auschwitz, Volker Koop details Höss’s military career, his conversion to Nazi ideology, and his ruthless commitment to the Nazi cause. At the age of fourteen, Höss joined the 21st Regiment of Dragoons and rose through the ranks to become the youngest non-commissioned officer in the German Army. After joining the Nazi party in 1922, he was convicted of participating in at least one political assassination, for which he spent six years in prison. In 1934, Höss became a Block Leader at Dachau concentration camp. By 1940, he would be given command of his own camp near the town of Auschwitz. Charged with carrying out the Final Solution of the Jewish question, Höss set about his task with relish. By his own estimation, he was responsible for the deaths of at least 3,000,000 individuals. Justice caught up with Höss after the German surrender. He was arrested on March 11th, 1946, after a year of posing as a gardener under a false name. He was found guilty of war crimes and hanged on April 16th, 1947.
The essential textbook on agent-based modeling—now fully updated and expanded Agent-Based and Individual-Based Modeling has become the standard textbook on the subject for classroom use and self-instruction. Drawing on the latest version of NetLogo and fully updated with new examples, exercises, and an enhanced text for easier comprehension, this is the essential resource for anyone seeking to understand how the dynamics of biological, social, and other complex systems arise from the characteristics of the agents that make up these systems. Steven Railsback and Volker Grimm lead students stepwise through the processes of designing, programming, documenting, and doing scientific research with agent-based models, focusing on the adaptive behaviors that make these models necessary. They cover the fundamentals of modeling and model analysis, introduce key modeling concepts, and demonstrate how to implement them using NetLogo. They also address pattern-oriented modeling, an invaluable strategy for modeling real-world problems and developing theory. This accessible and authoritative book focuses on modeling as a tool for understanding real complex systems. It explains how to pose a specific question, use observations from actual systems to design models, write and test software, and more. A hands-on introduction that guides students from conceptual design to computer implementation to analysis Filled with new examples and exercises and compatible with the latest version of NetLogo Ideal for students and researchers across the natural and social sciences Written by two leading practitioners Supported by extensive instructional materials at www.railsback-grimm-abm-book.com
The moral and political role of German journalists before, during, and after the Nazi dictatorship Journalists between Hitler and Adenauer takes an in-depth look at German journalism from the late Weimar period through the postwar decades. Illuminating the roles played by journalists in the media metropolis of Hamburg, Volker Berghahn focuses on the lives and work of three remarkable individuals: Marion Countess Dönhoff, distinguished editor of Die Zeit; Paul Sethe, “the grand old man of West German journalism”; and Hans Zehrer, editor in chief of Die Welt. All born before 1914, Dönhoff, Sethe, and Zehrer witnessed the Weimar Republic’s end and opposed Hitler. When the latter seized power in 1933, they were, like their fellow Germans, confronted with the difficult choice of entering exile, becoming part of the active resistance, or joining the Nazi Party. Instead, they followed a fourth path—“inner emigration”—psychologically distancing themselves from the regime, their writing falling into a gray zone between grudging collaboration and active resistance. During the war, Dönhoff and Sethe had links to the 1944 conspiracy to kill Hitler, while Zehrer remained out of sight on a North Sea island. In the decades after 1945, all three became major figures in the West German media. Berghahn considers how these journalists and those who chose inner emigration interpreted Germany’s horrific past and how they helped to morally and politically shape the reconstruction of the country. With fresh archival materials, Journalists between Hitler and Adenauer sheds essential light on the influential position of the German media in the mid-twentieth century and raises questions about modern journalism that remain topical today.
This book introduces the concept of novel process windows, focusing on cost improvements, safety, energy and eco-efficiency throughout each step of the process. The first part presents the new reactor and process-related technologies, introducing the potential and benefit analysis. The core of the book details scenarios for unusual parameter sets and the new holistic and systemic approach to processing, while the final part analyses the implications for green and cost-efficient processing. With its practical approach, this is invaluable reading for those working in the pharmaceutical, fine chemicals, fuels and oils industries.
Studies in bioequivalence are the commonly accepted method to demonstrate therapeutic equivalence between two medicinal products. Savings in time and cost are substantial when using bioequivalence as an established surrogate marker of therapeutic equivalence. For this reason the design, performance and evaluation of bioequivalence studies have received major attention from academia, the pharmaceutical industry and health authorities. Bioequivalence Studies in Drug Development focuses on the planning, conducting, analysing and reporting of bioequivalence studies, covering all aspects required by regulatory authorities. This text presents the required statistical methods, and with an outstanding practical emphasis, demonstrates their applications through numerous examples using real data from drug development. Includes all the necessary pharmacokinetic background information. Presents parametric and nonparametric statistical techniques. Describes adequate methods for power and sample size determination. Includes appropriate presentation of results from bioequivalence studies. Provides a practical overview of the design and analysis of bioequivalence studies. Presents the recent developments in methodology, including population and individual bioequivalence. Reviews the regulatory guidelines for such studies, and the existing global discrepancies. Discusses the designs and analyses of drug-drug and food-drug interaction studies. Bioequivalence Studies in Drug Development is written in an accessible style that makes it ideal for pharmaceutical scientists, clinical pharmacologists, and medical practitioners, as well as biometricians working in the pharmaceutical industry. It will also be of great value for professionals from regulatory bodies assessing bioequivalence studies.
The present study will help answer questions of tree type evolution, function, optimum, and tree construction types, using the approach of constructional morphology which to date has been widely neglected in palaeobotany and botany. First, the evolution pattern of the earliest Devonian trees is analyzed and explained, including a brief introduction of tree biomechanics. Then fossil and recent trees are studied from the viewpoint of constructional morphology with the main emphasis on the trunk as the most characteristic element of a tree. The various trunk constructions are classified into functional construction types, which are described and analyzed with respect to their biomechanical and biological properties. This functional comparison shows that the basic trunk constructions all appear in the Devonian, have specific advantages and disadvantages and constrain the possible growth habit of a tree. This study based on modern and fossil trees not only leads to a description but also to a causal understanding of the evolution and biology of the various tree types.
The authors begin their book with a general primer on modelling before addressing the problems of theory and conceptual framework for individual-based ecology. An extensive review illustrates the ecological problems that have been addressed with individual-based models.
Stochastic Processes for Insurance and Finance offers a thorough yet accessible reference for researchers and practitioners of insurance mathematics. Building on recent and rapid developments in applied probability, the authors describe in general terms models based on Markov processes, martingales and various types of point processes. Discussing frequently asked insurance questions, the authors present a coherent overview of the subject and specifically address: The principal concepts from insurance and finance Practical examples with real life data Numerical and algorithmic procedures essential for modern insurance practices Assuming competence in probability calculus, this book will provide a fairly rigorous treatment of insurance risk theory recommended for researchers and students interested in applied probability as well as practitioners of actuarial sciences. Wiley Series in Probability and Statistics
A riveting account of the dictator’s final years, when he got the war he wanted but led his nation, the world, and himself to catastrophe—from the author of Hitler: Ascent “Skillfully conceived and utterly engrossing.” —The New York Times Book Review In the summer of 1939, Hitler was at the zenith of his power. Having consolidated political control in Germany, he was at the helm of a newly restored major world power, and now perfectly positioned to realize his lifelong ambition: to help the German people flourish and to exterminate those who stood in the way. Beginning a war allowed Hitler to take his ideological obsessions to unthinkable extremes, including the mass genocide of millions, which was conducted not only with the aid of the SS, but with the full knowledge of German leadership. Yet despite a series of stunning initial triumphs, Hitler’s fateful decision to invade the Soviet Union in 1941 turned the tide of the war in favor of the Allies. Now, Volker Ullrich, author of Hitler: Ascent 1889–1939, offers fascinating new insight into Hitler’s character and personality. He vividly portrays the insecurity, obsession with minutiae, and narcissistic penchant for gambling that led Hitler to overrule his subordinates and then blame them for his failures. When he ultimately realized the war was not winnable, Hitler embarked on the annihilation of Germany itself in order to punish the people who he believed had failed to hand him victory. A masterful and riveting account of a spectacular downfall, Ullrich’s rendering of Hitler’s final years is an essential addition to our understanding of the dictator and the course of the Second World War.
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