This book examines the crucial role of a unique alpha-fetoprotein (AFP) in the treatment of cancer. AFP can deliver toxins through specific receptors re-expressed in the majority of cancer cells, serving as a targeted chemotherapy. More importantly, AFP+toxin harnesses the patient’s immune system in order to attack cancer. Depleting the regulatory top monocyte-derived suppressor cells (MDSCs) activates both the innate and adaptive immune responses. The thoroughly chosen toxins switch on apoptosis in MDSCs, restore the broken one in cancer cells, and destroy them naturally without any harmful by-products. Injections with AFP+toxin preparations have shown promising results in animals and the treatment of cancer patients. In addition to this breakthrough, the book also discusses the peroral administration of porcine AFP non-covalent complexes with selected toxins in patients with metastases. It will appeal to science researchers, clinicians, and medical students, as well as the more general reader.
Vladimir Vernadsky was a brilliant and prescient scholar-a true scientific visionary who saw the deep connections between life on Earth and the rest of the planet and understood the profound implications for life as a cosmic phenomenon." -DAVID H. GRINSPOON, AUTHOR OF VENUS REVEALED "The Biosphere should be required reading for all entry level students in earth and planetary sciences." -ERIC D. SCHNEIDER, AUTHOR OF INTO THE COOL: THE NEW THERMODYNAMICS OF CREATIVE DESTRUCTION
This book is a comprehensive introduction to the relationship between communism (understood as an ideological, political, and social project) and culture, broadly defined as the field of aesthetic production. Communism was a global phenomenon, and the global civil war of the 20th century was, in more than one respect, a cultural war, which involved some of the most influential figures of the last century. The book highlights and explains the impact of political mythologies in the effiorts to transcend the “bourgeois” legacies and engage in a social, cultural, and anthropological revolution. The authors examine the interplay between utopian goals and cultural practices in fields such as literature, visual arts, film, and humanities in general.
The work shows the fascination of topology- and geometry-governed properties of self-rolled micro- and nanoarchitectures. The author provides an in-depth representation of the advanced theoretical and numerical models for analyzing key effects, which underlie engineering of transport, superconducting and optical properties of micro- and nanoarchitectures.
Vladimir Arnold was one of the great mathematical scientists of our time. He is famous for both the breadth and the depth of his work. At the same time he is one of the most prolific and outstanding mathematical authors. This second volume of his Collected Works focuses on hydrodynamics, bifurcation theory, and algebraic geometry.
Vladimir Ilyich Lenin (1870-1924), was a Russian revolutionary, a communist politician, the main leader of the October Revolution, the first head of the Russian Soviet Socialist Republic and from 1922, the first de facto leader of the Soviet Union. He was the creator of Leninism, an extension of Marxist theory.
Lenin's writings of 1917 are testament to a formidable political figure. They reveal his ability to grasp the significance of an extraordinary moment in history. In this work, Slavoj Zizek situates the 1917 writings in their historical context.
This book explains modern and interesting physics in heavy-fermion (HF) compounds to graduate students and researchers in condensed matter physics. It presents a theory of heavy-fermion (HF) compounds such as HF metals, quantum spin liquids, quasicrystals and two-dimensional Fermi systems. The basic low-temperature properties and the scaling behavior of the compounds are described within the framework of the theory of fermion condensation quantum phase transition (FCQPT). Upon reading the book, the reader finds that HF compounds with quite different microscopic nature exhibit the same non-Fermi liquid behavior, while the data collected on very different HF systems have a universal scaling behavior, and these compounds are unexpectedly uniform despite their diversity. For the reader's convenience, the analysis of compounds is carried out in the context of salient experimental results. The numerous calculations of the non-Fermi liquid behavior, thermodynamic, relaxation and transport properties, being in good agreement with experimental facts, offer the reader solid grounds to learn the theory's applications. Finally, the reader will learn that FCQPT develops unexpectedly simple, yet completely good description of HF compounds.
Vladimir Propp is the Russian folklore specialist most widely known outside Russia thanks to the impact of his 1928 book Morphology of the Folktale-but Morphology is only the first of Propp's contributions to scholarship. This volume translates into English for the first time his book The Russian Folktale, which was based on a seminar on Russian folktales that Propp taught at Leningrad State University late in his life. Edited and translated by Sibelan Forrester, this English edition contains Propp's own text and is supplemented by notes from his students. The Russian Folktale begins with Propp's description of the folktale's aesthetic qualities and the history of the term; the history of folklore studies, first in Western Europe and then in Russia and the USSR; and the place of the folktale in the matrix of folk culture and folk oral creativity. The book presents Propp's key insight into the formulaic structure of Russian wonder tales (and less schematically than in Morphology, though in abbreviated form), and it devotes one chapter to each of the main types of Russian folktales: the wonder tale, the "novellistic" or everyday tale, the animal tale, and the cumulative tale. Even Propp's bibliography, included here, gives useful insight into the sources accessible to and used by Soviet scholars in the third quarter of the twentieth century. Propp's scholarly authority and his human warmth both emerge from this well-balanced and carefully structured series of lectures. An accessible introduction to the Russian folktale, it will serve readers interested in folklore and fairy-tale studies in addition to Russian history and cultural studies.
Remote Sensing of Sea Ice in the Northern Sea Route: Studies and Applications initially provides a history of the Northern Sea Route as an important strategic transport route for supporting the northern regions of Russia and cargo transportation between Europe and the Northern Pacific Basin. The authors then describe sea ice conditions in the Eurasian Arctic Seas and, using microwave satellite data, provide a detailed analysis of difficult sea ice conditions. Remote sensing techniques and the basic principles of SAR image formation are described, as well as the major satellite radar systems used for ice studies in the Arctic. The authors take a good look at the use of sensing equipment in experiments, including the ICE WATCH project used for monitoring the Northern Sea Route. The possibilities of using SAR remote sensing for ice navigation in the Northern Sea Route is also detailed, analysing techniques of automatic image processing and interpretation. A study is provided of regional drifting ice, fast ice and river ice in the coastal areas of the Arctic Seas. The book concludes with a review of the practical experience using SAR images for supporting navigation and offshore industrial activity, based on a series of experiments conducted with the Murmansk Shipping Company on board nuclear icebreakers.
Was the Bolshevik success in Russia during the revolution and civil war years a legitimate expression of the will of the people? Or did Russian workers, peasants, bourgeoisie, and upper-class groups pose numerous challenges to Bolshevik authority, challenges that were put down through unyielding repression? In this book distinguished scholars from East and West draw on recently opened archives to challenge the commonly held view that the Bolsheviks enjoyed widespread support and that their early history was simply a march toward inevitable victory. They show instead that during this period Russian society was at war with itself and with the Bolsheviks. Authors discuss such previously neglected subjects as government policies toward women and toward religious institutions, the protests of workers and peasants, and the anti-Bolshevik movements and parties. In particular, they investigate the actions of other political parties and White leaders, the peasant rebellions and workers' strikes, Bolshevik operations against the church, attitudes toward peasant and working-class women, and new data on Lenin (the last in a chapter by Richard Pipes). Describing not one civil war but several social, political, and military confrontations going on simultaneously, they portray a Russia in turmoil and an outcome that was by no means inevitable.
Power Supply Devices and Systems of Relay Protection brings relay protection and electrical power engineers a single, concentrated source of information on auxiliary power supply systems and devices. The book also tackles specific problems and solutions of relay protection power supply systems and devices, which are often not dealt with in the literature. The author, an experienced engineer with more than 100 patents, draws on his own experience to offer practical, tested advice to readers. A Guide to Relay Protection Power Supply for Engineers and Technicians The first chapter reviews the electronics and primary elements of the system, including transistors, thyristors, optocouplers, logic elements, and relays, and their principles of operation. This background gives staff who service relay protection power supply systems the necessary electronics knowledge to help them work more effectively with the equipment. The next chapters of the book then cover built-in digital protection relay power supplies, battery chargers, accumulator batteries, uninterruptible power supply, and characteristic features of auxiliary DC systems at substations and power plants. The final chapters discuss questions and problems that engineers and technicians may face. These include insulation problems, issues in auxiliary DC power supply such as voltage dips, and electromagnetic disturbances such as blackouts, spikes, and surges. The author also explains how to address them. Suitable for beginners and experienced engineers alike, the book is written for those who work with relay protection systems and with AC and DC auxiliary power systems in power plants and substations. It combines theory and practical recommendations to provide a valuable reference on power supply devices and systems.
This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.
This presentation of previously unpublished documents from the Hoover Institution Library & Archives draws a dramatic picture of the Russian Civil War and the establishment of the Communist dictatorship as witnessed by members of the Russian Social Democratic Workers' Party, or Mensheviks. When the opposing Bolsheviks consolidated their power to emerge as the ruling party of the 1917 revolution, the political influence of the Mensheviks was swept away, and most were driven to exile in Siberia. The historic power struggle that raged as the two parties vied for supremacy in postimperial Russia comes to light through these accounts—not official party statements but vivid reports, letters, and eyewitness testimonies by Mensheviks, ordinary citizens from diverse walks of life and different parts of the Soviet Union. Together, these materials create a mosaic of individual portraits and circumstances that illustrate the conflicts, struggles, and repression during the period of Soviet politics under Lenin. The primary source documents, skillfully edited and translated by Vladimir N. Brovkin, show the formation of a new mentality among Communist rulers and a new relationship to the workers, one that replaced multiparty competition with unquestioning obedience, military discipline, and intolerance.
Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. - Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. - Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. - Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
We present an improved and enlarged version of our book Nonlinear - namics of Chaotic and Stochastic Systems published by Springer in 2002. Basically, the new edition of the book corresponds to its ?rst version. While preparingthiseditionwemadesomeclari?cationsinseveralsectionsandalso corrected the misprints noticed in some formulas. Besides, three new sections have been added to Chapter 2. They are “Statistical Properties of Dynamical Chaos,” “E?ects of Synchronization in Extended Self-Sustained Oscillatory Systems,” and “Synchronization in Living Systems.” The sections indicated re?ect the most interesting results obtained by the authors after publication of the ?rst edition. We hope that the new edition of the book will be of great interest for a widesectionofreaderswhoarealreadyspecialistsorthosewhoarebeginning research in the ?elds of nonlinear oscillation and wave theory, dynamical chaos, synchronization, and stochastic process theory. Saratov, Berlin, and St. Louis V.S. Anishchenko November 2006 A.B. Neiman T.E. Vadiavasova V.V. Astakhov L. Schimansky-Geier Preface to the First Edition Thisbookisdevotedtotheclassicalbackgroundandtocontemporaryresults on nonlinear dynamics of deterministic and stochastic systems. Considerable attentionisgiventothee?ectsofnoiseonvariousregimesofdynamicsystems with noise-induced order. On the one hand, there exists a rich literature of excellent books on n- linear dynamics and chaos; on the other hand, there are many marvelous monographs and textbooks on the statistical physics of far-from-equilibrium andstochasticprocesses.Thisbookisanattempttocombinetheapproachof nonlinear dynamics based on the deterministic evolution equations with the approach of statistical physics based on stochastic or kinetic equations. One of our main aims is to show the important role of noise in the organization and properties of dynamic regimes of nonlinear dissipative systems.
This volume presents articles originating from invited talks at an exciting international conference held at The Fields Institute in Toronto celebrating the sixtieth birthday of the renowned mathematician, Vladimir Arnold. Experts from the world over--including several from "Arnold's school"--gave illuminating talks and lively poster sessions. The presentations focused on Arnold's main areas of interest: singularity theory, the theory of curves, symmetry groups, dynamical systems, mechanics, and related areas of mathematics. The book begins with notes of three lectures by V. Arnold given in the framework of the Institute's Distinguished Lecturer program. The topics of the lectures are: (1) From Hilbert's Superposition Problem to Dynamical Systems (2) Symplectization, Complexification, and Mathematical Trinities (3) Topological Problems in Wave Propagation Theory and Topological Economy Principle in Algebraic Geometry. Arnold's three articles include insightful comments on Russian and Western mathematics and science. Complementing the first is Jurgen Moser's "Recollections", concerning some of the history of KAM theory.
Covering numerous practical applications as yet not covered in any single source of information, this monograph discusses the importance of viscous and elastic properties for applications in both display and non-display technologies. The very well-known authors are major players in this field of research and pay special attention here to the use of liquid crystals in fiber optic devices as applied in telecommunication circuits.
This monograph is devoted to full-scale geoecological risk assessment in gas industry impacted polar areas and the relevant risk management options using innovative nature-like biogeochemical technologies. Readers will discover more about geoecological risks during gas production, transportation, storage and refining. Chapters discuss in detail the geodynamic dangers associated with the designing and building of main gas pipelines. The book has interdisciplinary appeal, and specialists and practitioners in environmental sciences, ecology, biogeochemistry and those within the energy sector who are interested in understanding ecosystems affected by anthropogenic impacts in severe climatic conditions will find it particularly engaging. Through this book, readers will learn more about recultivation of contaminated soils as well as health risk assessments of chemical substances associated with the gas industry.
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