This handbook focuses on different aspects of anti-aging and both preventive and regenerative medicine. It includes analysis of the paradigm of ageing and concepts of anti-aging medicine. Standards and technologies are highlighted in over twenty chapters all authored by international experts in regenerative medicine. Topics covered include: • Ageing, aging, and anti-aging: A Decalogue for anti-aging medicine • Lessons from Sicilian centenarians for anti-aging medicine • Molecular biomarkers and genetic aspects of aging • Future of peptides in clinical practice • Mitochondrial approaches in anti-aging medicine and in SARS-CoV2 infection • Tissue-specific autoantibodies in preventive medicine • Chronic stress as a psycho-neuro-immunological dysfunction • Gut-associated immune system and its health implications • Regenerative medicine with platelet-rich-plasma • Alzheimer’s disease: Preventive and anti-aging neurology • Autistic spectrum disorder and mitochondrial medicine • Integrative hormonal approach in anti-aging medicine • Preventive cardiology and phlebology • Aesthetic and anti-aging medicine • Preventive ophthalmology • Preventive oncology • Nutrition in healthy aging • Physical activity and fitness paradigms for anti-aging and longevity Recommended reading for clinicians working in anti-aging medicine as well as ageing people. The authors hope it will set a new “standard of anti-aging medicine” and as a tool in planning for the inevitable challenges we all will face caring for ageing patients and creating preventive-health programs.
Addressing the pathology of the heart and cardiovascular system from a forensic perspective, Pathology of the Heart and Sudden Death in Forensic Investigations guides the pathologist toward the effective resolution of cases. It critically reviews pertinent facts by revisiting pathologic findings and comparing them to etiopathogenic hypotheses, prop
Asymmetric synthesis has become a major aspect of modern organic chemistry. The stereochemical properties of an organic compound are often essential to its bioactivity, and the need for stereochemically pure pharmaceutical products is a key example of the importance of stereochemical control in organic synthesis. However, achieving high levels of stereoselectivity in the synthesis of complex natural products represents a considerable intellectual and practical challenge for chemists. Written from a synthetic organic chemistry perspective, this text provides a practical overview of the field, illustrating a wide range of transformations that can be achieved. The book captures the latest advances in asymmetric catalysis with emphasis placed on non-enzymatic methods. Topics covered include: Reduction of alkenes, ketones and imines Nucleophilic addition to carbonyl compounds Catalytic carbon-carbon bond forming reactions Catalytic reactions involving metal carbenoids Conjugate addition reactions Catalysis in Asymmetric Synthesis bridges the gap between undergraduate and advanced level textbooks and provides a convenient point of entry to the primary literature for the experienced synthetic organic chemist.
Maximize Reward and Minimize Risk with Modern C++ Embracing Modern C++ Safely shows you how to make effective use of the new and enhanced language features of modern C++ without falling victim to their potential pitfalls. Based on their years of experience with large, mission-critical projects, four leading C++ authorities divide C++11/14 language features into three categories: Safe, Conditionally Safe, and Unsafe. Safe features offer compelling value, are easy to use productively, and are relatively difficult to misuse. Conditionally safe features offer significant value but come with risks that require significant expertise and familiarity before use. Unsafe features have an especially poor risk/reward ratio, are easy to misuse, and are beneficial in only the most specialized circumstances. This book distills the C++ community's years of experience applying C++11 and C++14 features and will help you make effective and safe design decisions that reflect real-world, economic engineering tradeoffs in large-scale, diverse software development environments. The authors use examples derived from real code bases to illustrate every finding objectively and to illuminate key issues. Each feature identifies the sound use cases, hidden pitfalls, and shortcomings of that language feature. After reading this book, you will Understand what each C++11/14 feature does and where it works best Recognize how to work around show-stopping pitfalls and annoying corner cases Know which features demand additional training, experience, and peer review Gain insights for preparing coding standards and style guides that suit your organization's needs Be equipped to introduce modern C++ incrementally and judiciously into established code bases Seasoned C++ developers, team leads, and technical managers who want to improve productivity, code quality, and maintainability will find the insights in this modular, meticulously organized reference indispensable. Register your book for convenient access to downloads, updates, and/or corrections as they become available. See inside book for details.
This book develops and illustrates a comprehensive, multi-level framework for the evaluation of industrial research and development (R&D) activities and the measurement of their performance. The framework encompasses a set of hierarchical, interrelated levels at which R&D evaluation and performance measurement could be undertaken. This enlightening book focuses on the single industrial firm to study performance measurement of R&D functions, projects and individual researchers or engineers. It also addresses R&D evaluation from the point of view of financial markets, with a focus on the relationship between R&D investments and the value of the traded firm. The book broadens tin scope to study the role of technology platforms as R&D coordination mechanisms and also looks at the evaluation of R&D policies. This book will be warmly welcomed by researchers and postgraduate students in disciplines concerned with innovation management, technology policy, and finance who wish to gain an updated overview of R&D evaluation and performance measurement as well as exploring different units of analysis.
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