Today, well over 100 commercial antibiotics are available to treat everything from minor nuisances to life-threatening infections, but their indiscriminate use for nonbacterial ailments and agriculture has led to a disturbing trend of antibiotic resistance. Researchers are hard at work searching for new approaches to treat bacterial illnesses in an effort to preserve modern life as we know it. Antibacterials covers the topics relevant to entering this field of study. We discuss basic bacterial biology and the roles that bacteria play in the world. We also cover the history of antibacterials, both ancient and modern, as well as how commercial antibiotics work on a biochemical level. We examine the interplay between resistance, tolerance, and virulence, the threat that they pose, and ways that scientists are thinking about addressing them. Finally, we provide an overview of the antibacterial development process from initial lead discovery to clinical trials and commercialization.
Master's Thesis from the year 2012 in the subject Business economics - Marketing, Corporate Communication, CRM, Market Research, Social Media, grade: A-, Santa Clara University, language: English, abstract: Purchased in 2010 by 3G Capital Management, BK became privately owned with a single business corporate strategy. Immediately, the new ownership group set out to make impactful company-wide changes. The first change was the elimination of the firm’s “King” mascot in 2011, which was seen as edgy and targeted towards young men in their teens and twenties. The new phase, which began earlier this year, consists of a drastic change in overall brand strategy to reposition BK as a broad and appealing restaurant in the QSR industry. To attract a wider audience, such as women and health-conscious customers, BK has added a significant amount of menu items including smoothies, coffee drinks, and salads. Furthermore, it has set out to remodel around 1,500 restaurants. In place of the previous mascot, BK has enlisted A-list celebrities (i.e., David Beckham and Selma Hayek) to advertise its products. Another strategy that they plan to implement is to sell almost all of its 1,300 corporate stores to franchise stores in an effort to protect itself from commodity-cost swings and fixed costs. With significant competition from both current as well as fast-growing QSRs (i.e., Five Guys Burgers and Fries, Panera Bread, and Chipotle Mexican Grill), BK’s recent moves have been perceived as imitating the leader, McDonald’s, rather than differentiating the company. While it remains to be seen whether or not the strategy is enough to grow the business, a potential concern is whether 3G Capital Management is looking for long-term growth or settling for marginal growth in the short-term to fund their exit from the company by going back to a public entity. The current strategy conveys that BK is in “catch-up” mode instead of trying to distinguish itself as a premier QSR. Considering both internal and external factors, the firm needs to win back and increase its customer base as the way to grow its business. To do this, some recommendations for BK in the short-term are to introduce a happy hour that includes an accommodating menu of new products, offer nutritious kid’s meals that are part of a healthy, balanced diet, and launch an online ordering system for customers to pre-order meals for pick-up. In the longer-term, we suggest BK buy out the highest performing franchises to gain additional streams of revenue, implement an incentive program to reward the best franchise stores, and start a high density delivery service.
In New York Times bestselling author Victoria Laurie’s thirteenth Psychic Eye Mystery, Abby Cooper senses a convicted killer is innocent, but she’ll need hard evidence to save the woman before it’s too late… A ticked-off judge has tossed Abby in the slammer for contempt of court, and during her brief but unpleasant stay she learns the story of a condemned woman who is confronting a far more serious sentence. Skyler Miller has been found guilty of murder and faces the death penalty. Everyone believes she’s guilty, including her own family and her ex-husband—everyone, that is, except Abby, whose finely honed intuition tells her this woman doesn’t belong behind bars. With the help of her husband Dutch and her friend Candice, Abby launches into her own investigation to clear Skyler and find the real killer. But after a final appeal is denied and Skyler’s attorney scrambles for a stay of execution, time is running short—and the list of suspects keeps growing. There’s no margin for error as the life of an innocent woman hangs in the balance. . . .
Eastern Philosophy: The Basics is an essential introduction to major Indian and Chinese philosophies, both past and present. Exploring familiar metaphysical and ethical questions from the perspectives offered by a range of eastern philosophies, including Confucianism, Daoism, the main Buddhist and Hindu philosophical schools, as well as Jainism, this book covers key figures, issues, methods and concepts. Questions discussed include: What is the ‘self’? Is human nature inherently good or bad? How is the mind related to the world? How can you live an authentic life? What is the fundamental nature of reality? With timelines highlighting key figures and their contributions, a list of useful websites, pronunciation guides and further reading suggestions, Eastern Philosophy: The Basics provides an engaging overview of fundamental ideas in eastern philosophy. The second edition has been thoroughly revised and updated to take account of the most recent scholarship. It includes study questions for each chapter, an updated bibliography, a new section on the Yijing and expanded discussion of Indian philosophies and their basis in experience. Eastern Philosophy: The Basics is valuable reading for all students of philosophy and religion, especially those seeking to understand eastern thought.
The story of one citizen's fight to preserve a US stake in the future of clean energy and the elements essential to high tech industries and national defense. American technological prowess used to be unrivaled. But because of globalization, and with the blessing of the U.S. government, once proprietary materials, components and technologies are increasingly commercialized outside the U.S. Nowhere is this more dangerous than in China's monopoly of rare earth elements-materials that are essential for nearly all modern consumer goods, gadgets and weapons systems. Jim Kennedy is a retired securities portfolio manager who bought a bankrupt mining operation. The mine was rich in rare earth elements, but he soon discovered that China owned the entire global supply and manufacturing chain. Worse, no one in the federal government cared. Dismayed by this discovery, Jim made a plan to restore America's rare earth industry. His plan also allowed technology companies to manufacture rare earth dependent technologies in the United States again and develop safe, clean nuclear energy. For years, Jim lobbied Congress, the Pentagon, the White House Office of Science and Technology, and traveled the globe to gain support. Exhausted, down hundreds of thousands of dollars, and with his wife at her wits' end, at the start of 2017, Jim sat on the edge of victory, held his breath and bet it all that his government would finally do the right thing. Like Beth Macy's Factory Man, this is the story of one man's efforts to stem the dehumanizing tide of globalization and Washington's reckless inaction. Jim's is a fight we need to join.
Grannies, geishas, warriors, mystics, recluses, and predators_these are the dangerous women of traditional China. Through her exploration of the myth and history of the Ming, Victoria B. Cass brings their world brilliantly to life. In a culture that is resoundingly patriarchal, these women are a vivid counterpoint. Violating state-sponsored orthodoxies, the granny mocks and mimics, the geisha charms with her intellect, the warrior rules in icy superiority. Using new and freshly interpreted sources, the author leads us confidently into this surprising world, bolstering her erudite and engaging text with stunning color and black and white art of the period.
Intends to better equip readers with tools with which they can examine, and make sense of, the intersections of communication and gender. This text covers the variety of ways in which communication of and about gender and sex enables and constrains people's intersectional identities.
While attention has been focused on high-level struggles over control of giant enterprises in China and the former Soviet bloc, a remarkable but underreported revolution has been occurring at the grass-roots level. This volume examines the profiles of entrepreneurs and the patterns of business development in the post-socialist countries Bringing together the perspectives of all the social science disciplines, from anthropology through economics and political science to sociology, the contributors identify the criteria for survival and success of independent businesses in different environments. Their findings shed light not only on the "transition from socialism" at the micro-level, but also on the conditioning effects of different economic, historical, legal, and social conditions on the conduct of independent economic initiatives.
This issue of the Obstetrics and Gynecology Clinics con breast disorders covers imaging modalities, benign breast disorders, hereditary breast and ovarian cancer, contemporary management and treatment options for breast cancer. There is also an article devoted to Special considerations in breast cancer patients and survivors.
With expert contributions from experienced educators, research scientists and clinicians, Foye’s Principles of Medicinal Chemistry, Eighth Edition is an invaluable resource for professional students, graduate students and pharmacy faculty alike. This ‘gold standard’ text explains the chemical basis of drug action, emphasizing the structure-activity relationships, physicochemical-pharmacokinetic properties, and metabolic profiles of the most commonly used drugs.
The Facts On File Companion to World Poetry : 1900 to the Present is a comprehensive introduction to 20th and 21st-century world poets and their most famous, most distinctive, and most influential poems.
Eastern Philosophy: The Basics is an essential introduction to major Indian and Chinese philosophies, both past and present. Exploring familiar metaphysical and ethical questions from the perspectives of different Eastern philosophies, including Confucianism, Daoism, and strands of Buddhism and Hinduism, this book covers key figures, issues, methods and concepts. Questions discussed include: What is the 'self'? Is human nature inherently good or bad? How is the mind related to the world? How can you live an authentic life? What is the fundamental nature of reality? Throughout the book the relationships between Eastern Philosophy, Western Philosophy and the questions reflective people ask within the contemporary world are brought to the fore. With timelines highlighting key figures and their contributions, a list of useful websites and further reading suggestions for each topic, this engaging overview of fundamental ideas in Eastern Philosophy is valuable reading for all students of philosophy and religion, especially those seeking to understand Eastern perspectives.
This is a review of recent advances on the use of DNA microarray for diagnosing foodborne pathogens. Rapid detection and characterization of foodborne pathogens is critical for food safety. Many relevant technologies have been intensively developed to date. DNA microarray technology offers a new way to food safety involving pathogen detection and characterization. DNA microarray can be used for detection and characterization of pathogens by analyzing hybridization patterns between capture probes and nucleic acids isolated from food samples or bacteria. It allows more rapid, accurate, and cost-effective detection of pathogens compared with traditional approaches of cultivation or immuno-assays. The application of DNA microarrays to different foodborne bacteria, such as Campylobacter, Salmonella, Listeria monocytogenes, or Shiga toxin producing Escherichia coli, will improve their rapid identification and characterization of their genetic traits (e.g., antimicrobial resistance, virulence). As bacterial foodborne diseases are posing more serious threats to public healthcare, development of rapid and accurate methods for pathogen detection and characterization is critical to their proper control at the earliest time.
Language, both spoken and written, is key to understanding learning processes in the classroom. Research Methods for Classroom Discourse is for those who want to investigate spoken interaction or other discourse in the classroom. It lays out clearly the different approaches which are possible, identifying the key principles of each. It addresses the differences between them and the consequences these differences might have for teachers and researchers. Each approach is outlined in terms of practical methods advice, reasons for use, and case studies in which the approach has been used in classroom discourse. Common approaches such as conversation analysis, positioning theory, and critical discourse analysis are included alongside more specialised approaches such as discursive psychology and corpus linguistics. The context of classroom research is used to frame all discussions, with connections to other uses and applications where it can enhance the research being undertaken. The authors demonstrate the relationship between these different theoretical approaches through considering particular applications to common topics within classroom research, such as multilingual learners, knowledge/ knowing and identity. The authors assume no prior knowledge of technical terms and a glossary of key term terms is included. Practical issues such as ethics, data collection and transcription are an integral part of the discussion throughout, providing students with all the knowledge needed to embark upon a successful research project in this area.
Galectins are glycan-binding proteins implicated in intracellular signaling, cell–cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key players in the tumor microenvironment. They are expressed and released by different cell types, including tumor, stromal, endothelial and immune cells. Galectins critically influence tumor progression by modulating tumor cell migration, invasiveness, angiogenesis and antitumor immune responses. Intracellularly, galectins modulate survival and proliferation and they interact with a variety of signaling pathways. Given these extracellular and intracellular functions and their regulated expression at sites of tumor growth and metastasis, galectins have stimulated great interest as relevant biomarkers and novel targets in cancer therapy.
Race in the United States has long been associated with heredity and inequality while ethnicity has been linked to language and culture. In the Shadow of Race recovers the history of this entrenched distinction and the divisive politics it engenders. Victoria Hattam locates the origins of ethnicity in the New York Zionist movement of the early 1900s. In a major revision of widely held assumptions, she argues that Jewish activists identified as ethnics not as a means of assimilating and becoming white, but rather as a way of defending immigrant difference as distinct from race—rooted in culture rather than body and blood. Eventually, Hattam shows, the Immigration and Naturalization Service and the Census Bureau institutionalized this distinction by classifying Latinos as an ethnic group and not a race. But immigration and the resulting population shifts of the last half century have created a political opening for reimagining the relationship between immigration and race. How to do so is the question at hand. In the Shadow of Race concludes by examining the recent New York and Los Angeles elections and the 2006 immigrant rallies across the country to assess the possibilities of forging a more robust alliance between immigrants and African Americans. Such an alliance is needed, Hattam argues, to more effectively redress the persistent inequalities in American life.
This comprehensive, state-of-the-art textbook and reference volume in family gerontology reviews and critiques the recent theoretical, empirical, and methodological literature; identifies future research directions; and makes recommendations for gerontology professionals. This book is both an updated version of and a complement to the original Handbook of Families and Aging. The many additions include the most recent demographic changes on aging families, new theoretical formulations, innovative research methods, recent legal issues, and death and bereavement, as well as new material on the relationships themselves—sibling, partnered, and intergenerational relationships, for example. Among the brand-new topics in this edition are step-family relationships, aging families and immigration, aging families and 21st-century technology, and peripheral family ties. Unlike the more cursory summaries found in textbooks, the essays within Handbook of Families and Aging, Second Edition provide thoughtful, in-depth coverage of each topic. No other book provides such a comprehensive and timely overview of theory and research on family relationships, the contexts of family life, and major turning points in late-life families. Nevertheless, the contents are written to be engaging and accessible to a broad audience, including advanced undergraduate students, graduate students, researchers, and gerontology practitioners. Serious lay readers will also find this book highly informative about contemporary family issues.
The connections between communities and forests are complex and evolving, presenting challenges to forest managers, researchers, and communities themselves. Dependency on timber extraction and timber-related industries is no longer a universal characteristic of the forest community. Remoteness is also a less common feature, as technology, workforce mobility, tourism, and 'amenity migrants' increasingly connect rural to urban places. Forest Community Connections explores the responses of forest communities to a changing economy, changing federal policy, and concerns about forest health from both within and outside forest communities. Focusing primarily on the United States, the book examines the ways that social scientists work with communities-their role in facilitating social learning, informing policy decisions, and contributing to community well being. Bringing perspectives from sociology, anthropology, political science, and forestry, the authors review a range of management issues, including wildfire risk, forest restoration, labor force capacity, and the growing demand for a growing variety of forest goods and services. They examine the increasingly diverse aesthetic and cultural values that forest residents attribute to forests, the factors that contribute to strong and resilient connections between communities and forests, and consider a range of governance structures to positively influence the well being of forest communities and forests, including collaboration and community-based forestry.
The fifth volume of The History of Evil covers the twentieth century from 1900 through 1950. The period saw the maturation of intellectual movements such as Pragmatism and Phenomenology, and the full emergence of several new academic disciplines; all these provided novel intellectual tools that were used to shed light on a human capacity for evil that was becoming increasingly hard to ignore. An underlying theme of this volume is the effort to reconstruct an understanding of human nature after confidence in its intrinsic goodness and moral character had been shaken by world events. The chapters in this volume cover globally relevant topics such as education, propaganda, power, oppression, and genocide, and include perspectives on evil drawn from across the world. Theological and atheistic responses to evil are also examined in the volume. This outstanding treatment of approaches to evil at a determinative period of modernity will appeal to those with interests in the intellectual history of the era, as well as to those with interests in the political, philosophical and theological movements that matured within it.
Ronja Victoria Scholz assesses the performance of cellulose-based Cottonid for implementation as sustainable construction material. Quasi-static and fatigue tests are performed in varying hygrothermal test conditions using mechanical testing systems in combination with integrable climate chambers. To investigate humidity-driven actuation properties, customized specimen holders are designed. Accompanying microstructural in situ experiments in analytical devices enable a profound understanding of effective material-specific damage and failure mechanisms. The findings are transferred into strength-deformation diagrams as well as Woehler curves, which enable a comparative evaluation of several process-related and environmental influencing factors and can directly be used for dimensioning of Cottonid elements for structural applications. The interpretation of thermoelastic material reponse during loading is used as scientific value for lifetime prediction. Comprehensive investigations on industrial standard materials as well as structurally optimized Cottonid variants provide a scientific basis for categorizing material’s structural and functional performance towards common technical plastics and wood.
The book is an essential resource for those interested in investigating the lives, histories, and futures of indigenous peoples around the world. Perfect for readers looking to learn more about cultural groups around the world, this four-volume work examines approximately 400 indigenous groups globally. The encyclopedia investigates the history, social structure, and culture of peoples from all corners of the world, including their role in the world, their politics, and their customs and traditions. Alphabetically arranged entries focus on groups living in all world regions, some of which are well-known with large populations, and others that are lesser-known with only a handful of surviving members. Each entry includes sections on the group's geography and environment; history and politics; society, culture, and tradition; access to health care and education; and threats to survival. Each entry concludes with See Also cross-references and a list of Further Reading resources to guide readers in their research. Also included in the encyclopedia are Native Voices inset boxes, allowing readers a glimpse into the daily lives of members of these indigenous groups, as well as an appendix featuring the United Nations Declaration on the Rights of Indigenous Peoples.
The Garden of Perfect Brightness (Yuanming Yuan) in the western suburbs of the Quing capital, Beijing, was begun by the great Kangxi (r. 1661-1722) and expanded by his son, Yongzheng (r. 1722-1736) and brought to its greatest glory by his grandson, Qianlong (r. 1736-1796). A lover of literature and art, Qinglong sought an earthly reflection of his greatness in his Yuanming Yuan. For many years he designed and directed an elaborate program of garden arrangements. Representing two generations of painstaking research, this book follows the emperor as he ruled his empire from within his garden. In a landscape of lush plants, artificial mountains and lakes, and colorful buildings, he sought to represent his wealth and power to his diverse subjects and to the world at large. Having been looted and burned in the mid-nineteenth century by western forces, it now lies mostly in ruins, but it was the world’s most elaborate garden in the eighteenth century. The garden suggested a whole set of concepts—religious, philosophical, political, artistic, and popular—represented in landscape and architecture. Just as bonsai portrays a garden in miniature, the imperial Yuanming Yuan at the height of its splendor represented the Qing Empire in microcosm. Includes 62 color plates and 35 black & white photographs.
What role does taste play in contemporary youth culture? How do young people reproduce, or alternatively, reject gender norms? Using new research and the work of renowned theorists such as Judith Butler and Pierre Bourdieu, Victoria Cann argues that popular culture affects young people's experiences of masculinity and femininity and forces them to navigate a social minefield in which they are pressured to display tastes deemed appropriate for their gender. Combining her own unique empirical research with a strong theoretical framework, Cann widens and links the fields of gender and taste studies to show the everyday reality of twenty-first-century youth and their apprehensions - especially those of young boys- about participating in activities, or embracing pop-cultural preferences that have traditionally only been associated with the opposite sex.
This Element selectively examines a range of ideas and arguments drawn from the philosophical traditions of South and East Asia, focusing on those that are especially relevant to the philosophy of religion. The Element introduces key debates about the self and the nature of reality that unite the otherwise highly diverse philosophies of Indian and Chinese Buddhism, Hinduism, and Jainism. The emphasis of this Element is analytical rather than historical. Key issues are explained in a clear, precise, accessible manner, and with a view to their contemporary relevance to ongoing philosophical debates.
Understanding Quantitative and Qualitative Research in Psychology is the most hands-on, accessible and approachable guide to the entire research process, which fully explores both quantitative and qualitative methods to give students the knowledge and confidence they need. Students arepresented with a practically-focused guide to carrying out psychological research and are taken from formulating a research question through to collecting data, analysing datasets statistically with SPSS or qualitatively with a range of approaches, and finally presenting and thinking criticallyabout research findings. They are shown the importance of research ethics, and coverage of the replication crisis and the open science movement is considered throughout.The online resources present a wealth of opportunities for students to practice what they have learned, and the title is supported by an excellent range of video support materials for both the qualitative and quantitative sections, including SPSS screencasts for all relevant chapters, and a range ofvideos on interview skills.Digital formats and resourcesUnderstanding Quantitative and Qualitative Research in Psychology is available for students and institutions to purchase in a variety of formats, and is supported by online resources.The e-book offers a mobile experience and convenient access, along with self-assessment activities and multi-media content to provide additional learning support: www.oxfordtextbooks.co.uk/ebooks/.The online resources include:For students:- Videos demonstrating interview technique- SPSS screencasts showing students how to carry out the statistical analyses covered in the book- Flashcards- SPSS datasets- Audio files of sample interviews- Transcriptions of sample interviews- Initial codes for a sample thematic analysis- Memo template and transcription template to accompany the grounded theory chapter- SPSS output files- Answers to study questions- Web references- An example qualitative studyFor lecturers:- Customizable PowerPoint presentations- Image bank- Test bank- Additional worksheets- Answer sheets- Additional datasets- Additional SPSS output files
Changes in the routines of domestic life were among the most striking social phenomena of the period between the two World Wars, when the home came into focus as a problem to be solved: re-imagined, streamlined, electrified, and generally cleaned up. Modernist writers understood themselves to be living in an epochal moment when the design and meaning of home life were reconceived. Moving among literature, architecture, design, science, and technology, Machines for Living shows how the modernization of the home led to profound changes in domestic life and relied on a set of emergent concepts, including standardization, scientific method, functionalism, efficiency science, and others, that form the basis of literary modernism and stand at the confluence of modernism and modernity. Even as modernist writers criticized the expanding reach of modernization into the home, they drew on its conceptual vocabulary to develop both the thematic and formal commitments of literary modernism. Rosner's work develops a new methodology for interdisciplinary modernist studies and shows how the reinvention of domestic life is central to modernist literature.
Are you a leader looking for ways to enhance the culture at your workplace through your leadership style? Culture and leadership equate to cleadership. This book teaches the importance of using critical thinking skills to implement cleadership in your organization. Cleadership is used to create positive cultural-based leadership using best practices to enhance your workplace culture. The cleadership best practices assist leaders in developing leadership styles that promote a culture of workplace civility; increased employee support; valued employees; succession planning strategies to retain knowledge; mentoring strategies; and diversity, equity, and inclusion practices that are a part of daily life and normal business practices. Learning to enhance your workplace culture will lead to higher retention rates and satisfied employees and customers. This book assists with developing a culture in the workplace by valuing inclusivity; identifying and halting microaggressive behavior; and finding ways to value similarities, differences, and uniqueness to robustize organizational leadership practices.
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