Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references
Not so long ago, songs by the Andrews Sisters and Lawrence Welk blasted from phonographs, lilted over the radio, and dazzled television viewers across the country. Lending star quality to the ethnic music of Poles, Italians, Slovaks, Jews, and Scandinavians, luminaries like Frankie Yankovic, the Polka King, and "Whoopee John" Wilfart became household names to millions of Americans. In this vivid and engaging book, Victor Greene uncovers a wonderful corner of American social history as he traces the popularization of old-time ethnic music from the turn of the century to the 1960s. Drawing on newspaper clippings, private collections, ethnic societies, photographs, recordings, and interviews with musicians and promoters, Greene chronicles the emergence of a new mass culture that drew heavily on the vivid color, music, and dance of ethnic communities. In this story of American ethnic music, with its countless entertainers performing never-forgotten tunes in hundreds of small cities around the country, Greene revises our notion of how many Americans experienced cultural life. In the polka belt, extending from Connecticut to Nebraska and from Texas up to Minnesota and the Dakotas, not only were polkas, laendlers, schottisches, and waltzes a musical passion, but they shone a scintillating new light on the American cultural landscape. Greene follows the fortunes of groups like the Gold Chain Bohemians, illuminating the development of an important segment of American popular music that fed the craze for international dance music. And even though old-time music declined in the 1960s, overtaken by rock and roll, a new Grammy for the polka was initiated in 1986. In its ebullience and vitality, the genre endures.
More foods are now packaged in containers designed for direct cooking or heating, which encourages movement of substances into the foods. Indirect Food Additives and Polymers: Migration and Toxicology is an impressive review of basic regulatory, toxicological, and other scientific information necessary to identify, characterize, measure, and predict the hazards of nearly 2,000 of the plastic-like materials employed in packaging and identified by the FDA as indirect food additives. It presents the data underlying federal regulations, previously unavailable in one volume, and is a convenient resource for anyone working in the large number of related disciplines.
All Things Common was first published in 1966. Minnesota Archive Editions uses digital technology to make long-unavailable books once again accessible, and are published unaltered from the original University of Minnesota Press editions. In Dr. Peters' study of the Hutterian Brethren (commonly called Hutterites), a group of devoutly religious farmers who have established many communal colonies in the midlands of the United States and Canada, he first traces the historical development of the group and then describes in detail their way of life by focusing on the Manitoba colonies. After their church was founded in Central Europe at the time of the Reformation, the Hutterians moved slowly east until they settled in Russia, where they lived for over one hundred years. Then, in the 1870's, they immigrated to America and settled in the Dakota Territory. During World War I they fled to Canada under pressure of wartime hysteria. Since they moved to Canada, the Hutterians have encountered more problems but have successfully spread their colonies across the prairie provinces and back into the United States. At present, the Hutterians are the oldest and most successful community group in the history of western civilization. They believe that their practice of Christian communism is in true harmony with the spirit and teachings of early Christianity. Other aspects of their behavior such as the refusal to do military service and their disapproval of radio, television, dancing, movies, and cosmetics have made them a source of interest and concern to their neighbors. The book is a thorough introduction to the Hutterians for the general reader and will be of special interest to historians, theologians, sociologists, and economists.
This text offers 6th - 12th grade educators guided instructional approaches for including diverse young adult (YA) literature in the classroom as a form of social justice teaching and learning. Through the YA books spotlighted in this text, educators are provided pre-, during-, and after reading activities that guide students to a deeper understanding of topics that are often considered taboo in the classroom - race, racism, mental health, immigration, gender, sexuality, sexual assault - while increasing their literacy practices.
This book covers the structure and classification of adhesion molecules in relation to signaling pathways and gene expression. It discusses immunohistochemical localization, neutrophil migration, and junctional, functional, and inflammatory adhesion molecules in pathologies such as leukocyte decompression sickness and ischemia reperfusion injury. H
This accessible, easy-to-read book provides readers with different perspectives on the subject of painkillers, examining their history, production, uses, and dangers. Many different drugs are effectively used as painkillers—substances that greatly improve the quality of life for those who suffer from temporary or recurring pain. This book presents an in-depth overview of opiates, opioids, and other painkilling substances such as non-steroidal anti-inflammatory drugs (NSAIDs) that have been in use from ancient times up to the contemporary era. It also addresses the risks of painkiller use, their misuse, and potential overdose concerns. The latest in the Story of a Drug series and written by a subject expert who has published widely on drug use and pharmacology, this book presents a brief review of the science of how different painkiller drugs work before covering these substances' respective effects and applications; the issues regarding the production, distribution, and regulation of painkiller drugs; and research findings on painkiller use, abuse patterns, addiction, and policy issues. The easy-to-understand text presents scientifically accurate information that enables readers to better understand the key role of painkillers in our 21st-century world.
Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references
Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation
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